Posted by admin on Jan 31, 2016 in |
An hitherto new unreported [16]-membered dioxadiazanapthaldehyde based macrocyclic ligand (L) 2,11-dioxa-23,30-diaza heptacyclo [30.4.0.04,9.012,21.014,19.024,29.034,39] -tetraconta-12,14,16, 18,20,22, 24,26,28,30,32,34,36,38,40-pentadecaene, has been synthesized by two different synthetic routes each involving two stages. 2-Hydroxy-1-Napthaldehyde in the presence of potassium carbonate was treated with α,α’-dibromo-o-xylene to yield the dial derivative(I). The dial derivative(I) was further made to undergo Schiff base condensation with 1,2-diaminobenzene to yield the bright yellow macrocycle (L) in good yield. In the second method the Schiff base condensed product Napthaloph was synthesized and allowed to undergo Williamson’s condensation with α,α’-dibromo-o-xylene to yield the ligand (L). The neutral sixteen membered tetradentate dioxadiaza ligand(L) readily complexes with Co(III), Ni(II) and Cu(II) perchlorate salts in 1:1 mole ratio to yield complexes of formulae [Co(L)X2]ClO4, [Ni(L)X2], [Cu(L)X]ClO4, (X = Cl–, Br– and NO3–). The complexes were also synthesized by the metal template method. The yield of the template procedure was found to be greater than the non-template method. The ligand and the complexes were characterized by elemental analysis, electronic spectroscopy, IR, Conductivity measurements, EPR, magnetic susceptibility,...
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Posted by admin on Jan 31, 2016 in |
The present investigation deals with the histological and histopathological altarations in Channa striatus infected with fungi Aspergillus fumigates and Aspergillus niger. Fresh water murrels were collected from Dharmasagar and Hasanparthy lakes and Local fish markets of Warangal district. This is due to the nature of their habitats as many native species of fish suffer from living beneath turbid water. Among the recent emerging infection diseases responsible for severe population declines in plant and animal taxa, fungal and fungi-like microbes have emerged as significant contributors. Isolated fungi from infected fish bodies were identified as Aspergillus fumigatus and Aspergillus niger. Histopathologically different kinds of destructions were observed in Skin, Muscles, Gills and Liver of the infected fish. Histopathological observations of stained sections of infected fishes revealed pathological lesions of varying severity in studied organs including skin (exhibits compeletely lost epidermis, destiended cells, many of cells lost their cytoplasm and nuclei. Necrotized muscular layer with the formation of granulomas and encysted conidiophores), gills ( hyperplasia and hyperplasia of lamellar epithelium, fusion of...
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Posted by admin on Jan 31, 2016 in |
Objective: This study was aimed to evaluate the role of GLP-1, GIP in the hypoglycemic activity of Phlogacanthus thyrsiflorus Nees. Materials and Methods: We have evaluated the influence of Phlogacanthus thyrsiflorus Nees, a traditionally used antidiabetic medicinal plant on some metabolic parameters, glucose homeostasis, insulin production, glucagon like peptide 1 (GLP1) and gastric Inhibitory Polypeptide (GIP) in high fat diet fed (HFD) obese mice and High fat diet + streptozotocin (HFD + STZ) induced diabetic mice. Oral glucose tolerance test (OGTT) was done to study the glucose homeostasis in both HFD fed obese mice and HFD + STZ induced diabetic mice. Effect of P. thyrsiflorus on pancreatic beta cells was assessed using histological studies. Results: Phlogacanthus thyrsiflorus aqueous extract (PTAE) treatment lowered the blood glucose levels in HFD fed obese mice and HFD + STZ induced diabetic mice significantly. PTAE treatment reduced the weight gain in HFD fed obese mice and prevented the constant weight loss in HFD+STZ induced diabetic mice. PTAE treatment decreased the food intake significantly in...
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Posted by admin on Jan 31, 2016 in |
A new single stability-indicating isocratic reversed phase ultra-performance liquid chromatographic (RP-UPLC) method with a shortest run time of 2.5 minutes is developed for the determination of assay of bicalutamide an anti-cancer drug from its finished dosage form in the presence of its forced degradation products. The method is developed using Waters Aquity BEH C18 column with mobile phase containing an isocratic mixture of solvent A and B. The eluted compounds were monitored at 270 nm. Bicalutamide tablets were subjected to the stress conditions of oxidative, acid, base, hydrolytic, thermal, and photolytic degradation, within which forced degradants were well-resolved from main peak, thus proving the stability indicating power of the method. The developed method is validated as per ICH guidelines with respect to specificity, linearity, Accuracy, precision and robustness. The same method is also tested for evaluation of dissolution where recovery, linearity and solution stability were evaluated and found satisfactory. As a part of cleaning validation-Residue analysis, recovery of 0.5ppm on two different surfaces (Stainless steel and Class-A Glass) were...
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Posted by admin on Jan 31, 2016 in |
Sustained release Carvedilol tablets constituting reservoir pellets developed in this study is an attempt to investigate the effect of drug release from matrix. The sustained release Carvedilol tablets were prepared by using different combination with release modifier (ethyl cellulose 10 cps and Eudragit RS 100). Tablets containing disintegrant pellets (Crosspovidon) with active ingredient demonstrated a sustained rate of drug release. The Carvedilol tablets were prepared using different ratios of pellets. After 12 hours of dissolution study, Carvedilol release from the matrix systems were 92.35%, 92.37%, 95.25%, 93.26%, 92.87% and 90.4 2% from formulation F1, F2, F3, F4, F5 and F6 respectively. Formulation F2 (10% of Eudragit RS 100) exhibited 95.21% Carvedilol release in 12 h and satisfied all the physical evaluation parameters hence, considered as optimized batch. The Carvedilol sustained release F2 batch showed non-Fickian diffusion...
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