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ISSN (Online): 0975-8232,
ISSN (Print): 2320-5148

International Journal Of
Pharmaceutical Sciences And Research

IJPSR is indexed with Embase

An International Journal published monthly
An Official Publication of Society of Pharmaceutical Sciences and Research

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Posted by on Dec 31, 2015 in | 0 comments

ANTIOXIDANT AND ANTIBACTERIAL OF AERIAL PART ESSENTIAL OIL AND SOME ORGANIC EXTRACTS FROM THE ALGERIAN MEDICINAL PLANT PULICARIA MAURITANICA COSS

Pulicaria mauritanica Coss is one of the endemic medicinal plants from Algerian Sahara. It’s used for many traditional therapies for various diseases. The aims of this study were to analyse the chemical composition of aerial part essential oil of P.mauritanica coss and antibacterial properties. We investigate the content of different organic extracts on phenolics and flavonoids, and also their antioxidant activities (Ferric reducing and DPPH test). The GC-MS analysis revealed fifteen compounds representing 97.0 % of the total oil containing carvotanacetone (89.2 %), β-eudesmol (3.2 %) and nerolidol E (0.7 %) as a major components. The essential oil exhibited a strong antibacterial effect as a diameter of zones of inhibition (24.3 ± 2.1 mm and 22.7 ± 1.5 mm) against Citobacter frendii and Enterobacter cloaceae, respectively. We found the methanolic extract of flowers presented the highest level of phenolics and flavonoids contents (329.9 ± 0.3 mg GAE/g and 130 ± 1.1 mg CE/g). The antioxidant activity of the some organic extracts of P. mauritanica presented an average reducing power...

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FORMULATION AND EVALUATION OF AMLODIPINE BESYLATE ORAL THIN FILMS

The aim of the present work was to formulate and evaluate oral thin films for sublingual administration of Amlodipine besylate. Amlodipine besylate is a calcium channel blocker used in the treatment of hypertension, angina and other cardiovascular diseases. Films were formulated using HPMC (15cps, 60cps), PVA, and HPC as different film-forming agents (3 and 4% (w/v)). Poly ethylene glycol 400 was used as plasticizer and SSG as disintegrant. Sodium saccharine was used to mask the bitter taste of the drug. Films were prepared by solvent casting method and evaluated for drug content, disintegration time, thickness, tensile strength, folding endurance and % cumulative drug released. The optimized formulation (HPMC 15 cps) F5 exhibited acceptable folding endurance (95), disintegration time (33 sec) and drug release of 98.5% in 360 sec. It can be concluded from the study that the Amlodipine oral thin films for sub lingual administration can be a potential novel drug dosage...

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PHILADELPHIA CHROMOSOME IN PRETHERAPEUTIC CASES OF CHRONIC MYELOGENOUS LEUKEMIA

Chronic myeloid leukemia (CML) is a clonal myel0 proliferative disorder due to neoplastic transformation of myeloid stem cells. The characteristic Philadelphia Chromosome translocation t(9:22) (q 34: q11) juxta poses the c-abl oncogene from chromosome 9 with break point cluster region (bcr) on chromosome 22 resulting in the generation of aberrant bcr/abl transcripts. The abnormal bcr/abl tyrosine kinase gene product has enhanced activity compared to the wild type c-abl tyrosine kinase and is believed central to the pathogenesis of CML. Most of the patients in chronic phase who are treated with cytotoxic agents eventually develop a fatal blast phase that is the end stage in which the patient usually fails to respond combination chemotherapy and only treatment remain after that is allogenic bone marrow transplantation. Since the philadelphia chromosome is the most consistant abnormality in CML patients and as it possess both diagnostic as well as prognostic importance, it’s detection is mandatory to establish the diagnosis of CML and for planning of chemotherapy. Our study is a preliminary work to...

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SYNTHESIS OF HETEROCYCLIC NITROGEN COMPOUNDS BY CLOSURE REACTIONS USING TETRAACETYLETHANE WITH VARIOUS PRIMARY AMINES

This work includes synthesis of new five, six, and seven-heterocyclic nitrogen compounds by closure reactions of tetraacetylethane (3) with primary amines in refluxing ethanol and acetonitrile as solvents and without using any catalysts. The tetraacetylethane melting point 184-189 ºC was prepared by condensation of two anhydrous molecules of sodium salt of acetylacetone and in the presence of dry ether as solvents and Iodine as a catalysts. The heterocyclic nitrogen compounds as: 1,4,5,8-tetramethyl-4a,8a-dihydropyridazino[4,5-d]pyridazine (11), 3,7-bis (2,4-dinitrophenyl)1,4,5,8-tetramethyl-4a,8a- dihydropyridazino [4,5-d]pyridazine (12), 1,4,5,8-tetramethyl-1,4a,5,8a-tetrahydro-oxazino[4,5-d]oxazine (13), 4,4′,6,6′-tetramethyl-[5,5′-bipyrimidine]-2,2′(5H,5H’)-dione (14), 2,2′,4,4′-tetramethyl-3H,3H’-3,3′-bibenzo[b][1,5]diazepine (15), (4,6-dimethyl-1, 3 dimethyl enepyrrolo[3,4-c]pyrrole-2,5-diyl)bis(ethan-1-amine) (16), 4,4′-(4,6-dimethyl-1,3-dimethylene pyrrolo[3,4-c]pyrrole 2,5-diyl) dibenzoic acid (17), 2,5-bis(4-bromophenyl)-4,6-dimethyl-1,3-dimethylene-pyrrolo[3,4-c] pyrrole (18), 1,1′-((4,6-dimethyl-1,3-dimethylenepyrrolo[3,4-c] pyrrole -2,5-diyl) bis (4, 1-phenylene)) bis (ethan-1-one) (19), were prepared via condensation of compound (3) with primary amines (e.g. , hydrazine hydrate and primary aromatic amines) in 1:2 molar ratios. The compounds (11-19) were also synthesized by microwave irradiation of starting materials without using any solvent to give excellent yields of these compounds ranging between 80-95. Compounds (11-19) have been identified by spectroscopic methods, IR, UV, 1H-NMR, 13C-NMR (DEPT. 90...

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SYNTHESIS AND ANTIBACTERIAL ACTIVITY OF NOVEL α-AMINOPHOSPHONATES BEARING A QUINOLINE MOIETY

A novel aminophenylaminoquinoline analogues have been synthesized starting from 4,7 dichloroquinloine and (p-phenylenediamine 2a, o-phenylenediamine 2b or m-phenylenediamine 2c). The one pot reaction with aldehydes and triphenylphosphite in presence of LiClO4 as a Lewis acid catalyst led to the formation of novel α-aminophosphonate derivatives bearing quinoline moiety in good yields. The synthesized compounds have been characterized on the basis of the spectral analysis.  All the synthesized compounds were screened for in vitro antibacterial activity and most of them showed a potency against both gram positive and gram negative...

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