Posted by admin on Oct 31, 2015 in |
A series of Oxadiazole derivatives (4a-d) have been synthesized from (2, 4, 5-triphenyl-imidazole-1-yl)-acetic acid hydrazide under various reaction conditions. Elemental analysis, IR, 1H NMR and mass spectral data confirmed the structure of the newly synthesized compounds. All the synthesized Oxadiazole derivatives have been investigated for their anti-fungal and antimicrobial activity showing moderate to good activity. The anti-fungal activity of the newly synthesized compounds was compared with the standard drug Voriconazole. The oxadiazole derivatives showed moderate to good ant-fungal activity. The compounds having 4-methoxy group showed good activity (81%). The Oxadiazole derivative having 4-flourophenyl group showed highest activity (82.14%). The results of anti-microbial and anti-fungal activity clearly indicated that oxadiazole ring bearing 2, 4, 5-triphneylimidazole have moderate...
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Posted by admin on Oct 31, 2015 in |
The present study investigated total carotenoid content of twelve mango varieties of Bangladesh. Change in the total carotenoid content at various stages of maturity was also determined. Carotenoids are bioactive substances in food with powerful antioxidant activity. It has role in enhancement of the immune response and reduction of the risk of degenerative diseases such as cancer, cardiovascular diseases, cataract and macular degeneration. Mango is the leading seasonal cash crop of the northwestern region of Bangladesh. The mango (Mangifera indica) (Bangla- aam) is the king of fruits in Bangladesh. It’s a fleshy stone fruit. Mango is generally very sweat and tasty common fruits in Bangladesh. It’s also one of the most popular fruits in the world. Total carotenoid content in twelve mango varieties was analyzed by solvent extraction method followed by spectrophotometric method. Mangoes contain different amount of total carotenoid in green, semi-ripe and ripe stages. Carotenoid content in green mango was 3.09 μg/100m while that of semi-ripe mango was 70.875 μg/100gm and ripe mango was 251.74 μg/100gm. Among...
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Posted by admin on Oct 31, 2015 in |
The present study was aimed to investigate the antihyperglycemic effect of the Dipteracanthus prostratus nees. And it’s probable mechanism of action in Streptozotocin induced diabetes. Wistar albino rats were used to evaluate the antihyperglycemic effect of toluene (TEDP, 100 mg/kg and 200 mg/kg, body weight) and methanolic (MEDP, 100 mg/kg and 200 mg/kg, body weight) extract of D. prostratus. Changes in body weight and blood glucose level were evaluated at the beginning of the experiment and on day 7, 14, and 21 subsequently. Lipid profile and histopathological examination were also performed. TEDP at 200 mg/kg produced a significant stimulating body weight and reduced blood glucose level in treated diabetic rats from day 7, apart that MEDP also showed similar activity from day 14. Furthermore, significant differences in lipid profiles by TEDP treated rats at 200 mg/kg, as compared to diabetic control and normal rats were also observed. Histopathological studies showed comparable regeneration of islet cells necrosed by Streptozotocin, by both the extracts. In conclusion results revealed that the TEDP...
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Posted by admin on Oct 31, 2015 in |
Patients undergoing Haemodialysis are mostly affected with their physical and mental function. Assessing Health Related Quality Of life is mainly to challenge these conditions in patients and provide a better quality of life. An observational prospective study was conducted in the dialysis ward of a tertiary care hospital for a period of 6 months using KDQOL, consisting of 36 valid items focusing on the physical, mental component summary, burden of kidney disease, symptoms and effects of disease in daily life. A total of 99 patients of all the age and sex groups and patients on Haemodialysis were included. Comparing all the aspects of HRQOL in patients undergoing Haemodialysis, majority (N=59) were illiterate, maximum of patients of age group (40-49) were mostly affected, males being more. The sleep pattern, as observed, a maximum of patients had either lack of sleep or average sleep, the scores being 5, 6, and 7 for a count of 10. Higher number of patients were affected with hypertension (N=48). When comparing the physical, emotional and...
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Posted by admin on Oct 31, 2015 in |
Background: Diabetes is a group of metabolic diseases characterized by hyperglycemia resulting from defects in insulin secretion, insulin action, or both. Type 2 diabetes causes the combination of resistance to insulin action and an inadequate compensatory insulin secretory response. The degree of hyperglycemia sufficient to cause pathologic and functional changes in various target tissues, but without clinical symptoms, may be present for a long period of time before diabetes is detected. Long-term complications of diabetes include retinopathy with potential loss of vision; nephropathy leading to renal failure; peripheral neuropathy with risk of foot ulcers, amputations, and Charcot joints; and autonomic neuropathy causing gastrointestinal, genitourinary, and cardiovascular symptoms and sexual dysfunction. Patients with type 2 diabetes have an increased incidence of atherosclerotic cardiovascular, peripheral arterial, and cerebrovascular complications. Aim: The aim of this study was to determine the association between plasma human cartilage glycoprotein 39 (YKL-40) and glycated hemoglobin (HbA1C) in type 2 diabetic patients. Materials and methods: Thirty type 2 diabetic patients with the age group of 35 to...
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