Posted by admin on Sep 30, 2015 in |
Objective: To evaluate hypoglycemic responses of Kasni (Cichorium intybus) seed preparations in combination with oral hypoglycemic agent in treatment of patients of newly diagnosed type2DM. Methods: Newly diagnosed 90 patients of type2DM, age 35-65years, of either sex were divided into 3 groups. Each group had 30 patients (19 male and 11 females) matched with each other in terms of age and sex. In group A, only Glycomet SR once a day and in group B/C 6 grams crude seed powder or 50 ml decoction of crude seed powder twice a day in combination with Glycomet SR once in a day, was given for 90 days. FBG and PPBG were measured across 7 time periods and HbA1c levels were measured at zero and 90th day. Results: All the three groups shown a significant reduction in FBG and PPBG across the seven time periods. Post hoc TukeyHSD test shown that there was a significant difference between group A&B (p=0.027) and group A&C (p=0.000) for FBG and group A&B (p=0.019) and group...
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Posted by admin on Sep 30, 2015 in |
The use of natural products for the treatment of various diseases has a long history. In the present study, the anti-oxidative, cytotoxic and phytochemical properties of ethanol extract of a local variety of Piper betle leaves cultivated in Potia, Bangladesh has been investigated. The antioxidant and cytotoxic activity of the Piper betle ethanol extract were evaluated by DPPH (1, 1-diphenyl-2-picrylhydrazyl) free radical scavenging method and brine shrimp lethality bioassay method, respectively. Preliminary phytochemical group tests were also done to investigate the phytochemical properties of the extract. Leaf extract showed significant DPPH free radical scavenging effect compared to standard antioxidant ascorbic acid. IC50 value of ascorbic acid and leaf extract was found 1.81μg/ml and 151.36μg/ml respectively. In brine shrimp lethality bioassay LC50 value of Piper betle ethanol extract was found 274.63862µg/ml with 95% confidence limit where the lower and upper limits were 198.39 µg/ml and 387.18µg/ml respectively, which indicates that the Piper betle leaf extract has promising cytotoxic effect. Phytochemical analysis was found to be positive for alkaloid, glycosides, terpenoids,...
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Posted by admin on Sep 30, 2015 in |
A simple, reproducible and economical UV spectrophotometric method was developed for determining the potency of ciprofloxacin HCl in tablet dosage forms marketed in Bangladesh. Standard curves of ciprofloxacin HCl in the media of 0.1N HCl and distilled water were obtained by plotting absorbance versus concentration where calibration curve was found to be linear (r2>0.99). The average potency value for seven tablet samples (C1, C2, C3, C4, C5, C6 and C7) measured by HPLC method was 99.08±0.60% for 0.1 N HCl taking the absorbance at 277nm and 98.76±0.69% in case of distilled water at 276 nm, whether the value determined by this UV spectrophotometric method was quite satisfactory being 98.15±0.76% and 97.64±0.71%, respectively. In a separate experiment, efficiency of this method in practice was checked by determining the thermostability of ciprofloxacin HCl to find out how severely that degrades in high temperature conditions. Development of such economical UV spectrophotometric method will encourage low-investing pharmaceutical companies to employ this alternative method in quality control laboratories for routine analysis of ciprofloxacin...
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Posted by admin on Sep 30, 2015 in |
Introduction: Drug related problems occur commonly in patients who often receive polypharmacy with multiple co-morbid conditions. This constitutes a major health problem because of their negative consequences with increased morbidity and mortality. Aims and Objectives: The aim of the study was to assess the impact of clinical pharmacist interventions in drug therapy in hospitalized diabetes mellitus patients with hypertension. Methodology: A Prospective interventional study was carried out in the medicine wards of a tertiary care teaching hospital over a period of 10 months from September 2013 to June 2014. The drug therapy details of the patients were collected from inpatient case records. Clinical pharmacist reviewed the drug therapy, identified the drug related problems during ward rounds and discussed with the physicians and suitable suggestions was provided which had been documented. Results: A total of 147 drug therapy problems were identified from 111 patient case records. The number of drug related problems was predominant in males than females. Drug related problems were commonly seen in patients aged between 61-80 years...
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Posted by admin on Sep 30, 2015 in |
Objective: Comparative screening of Polyherbal preparations for anti-diabetic and antioxidant activity in rats. Materials and Methods: The blood glucose lowering activity of the Polyherbal preparation 1and 2 was studied in normal rats and alloxan-induced diabetic rats after oral administration at doses of 1.0 ml/kg body wt. Blood samples were collected from the tail vein method on 1,7, 15, and 23rd day. Biochemical parameters like SGOT, SGPT, Liver Glycogen, Urea, Creatinine, LDL, Cholesterol etc were evaluated. Effect was also observed on antioxidant activity and learning and memory dysfunction in diabetes. The data was compared statistically using the one-way ANOVA method followed by the Dunnett test. Results: The Polyherbal preparation 1and 2 produced significant (P<0.05,0.01) reduction in the blood glucose level and other biochemical parameters in diabetic rats after 23 days of study compared with that of control and Metformin. They also have significant antioxidant activity effective in diabetic neuropathy and learning and memory dysfunction. Conclusion: The Polyherbal preparation 1 and 2 showed antidiabetic in diabetic rats. This preparation can be...
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