Posted by admin on Aug 31, 2015 in |
The present study outlines a systematic approach for Formulation and Evaluation of Immediate release Tablets of Abacavir and Zidovudine tablet. Combination of anti retiro-viral creates multiple obstacles to HIV replication to keep the number of off springs low, reduce the possibility of superior mutations, decrease viral load and potentiate synergistic activity with one another, combining two drugs into one tablet reduces the number of individual medications1. To achieve this goal various prototype formulation trials were taken with varying compositions of diluents and disintegrant and evaluated with respect to their various quality control tests such as Thickness, hardness, weight variation, dissolution, disintegration, hardness and assay. The formula was finalized by comparing the In-vitro dissolution profile of all formulations with the respective individual marketed products. The in vitro release study was performed in 0.1N Hcl upto 60 min. Among all the formulations, formulation F6 release profile was good as compared to the other formulations. Forced degradation studies at 550C & Stability studies at 40±2ºC/75±5%RH (accelerated condition) for 1& 3 months indicated...
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Posted by admin on Aug 31, 2015 in |
The present study focuses on the synthesis of ZnO nanoparticles by chemical method in alcohol base using three different capping agents-Thioglycerol, oleic acid and Triethanol amine (TEA). The effect of concentrations was analyzed for their effectiveness in particle growth and antibacterial activity. The antibacterial activity of ZnO nanoparticles using these capping agents at different concentrations was tested against six laboratory microorganisms namely Escherichia coli, Bacillus subtilis, Pseudomonas aeruginosa, Staphylococcus aureus, Proteus, and Klebsiella by agar well diffusion method. Zone of inhibitions produced by ZnO nanoparticles with different capping agents was tabulated. The quantitative measurement of zones of inhibition led to the conclusion that all the capping agents were effective in inhibiting growth of different organisms of which the maximum activity was shown by Thioglycerol, capped ZnO nanoparticles at a concentration of 0.12% against all...
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Posted by admin on Aug 31, 2015 in |
The work was aimed to develop an immediate release tablet formulation of Fenofibrate and Rosuvastatin in combination for better treatment as well as management of hypercholesterolemia and prevention of cardiovascular diseases. The target was also set to improve the dissolution profile of poorly soluble Fenofibrate. For manufacturing these immediate release combined formulation tablets, Hot-Melt Technology was used which helped in enhancing dissolution profile and moreover, here amino acids are used in conjunction with other excipients. In the developed formulation, the amino acids imparted its action as excipient by helping in the solubilization process which facilitated the release rate of Fenofibrate. The formulated tables were then investigated for hardness test, friability test, weight uniformity and dissolution test. The results showed that all tablets met the expected requirements for these tests and the release rate of fenofibrate also got improved giving an excellent dissolution profile for both fenofibrate and...
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Posted by admin on Aug 31, 2015 in |
The Zingiberaceae has the great importance in the plant kingdom because the members of this family give up spices, perfumes, dyes and valuable medicines. Alongside, a number of species of this family are cultivated for flowering. Mango ginger is one of the important species of this family having medicinal and biological properties such as antiageing, antibacterial, antioxidant, anti-inflammatory, antiallergic, antifungal, platelet aggregation inhibition activity and analgesic activity. In Ayurveda and Unani medicines of system, its rhizomes are useful as expectorant, appetizer, alexteric and laxtative. The rhizomes of mango ginger are also used in skin diseases, bronchitis, asthama and inflammatiom. Present examination aims to evaluate and compare antioxidant potential of different extracts of mango ginger using 1,1-diphenyl-2-picrylhydrazyl assay. In this study, methanol and ethyl acetate extracts of mango ginger rhizomes was estimated as good antioxidant activity which is may be due to phenolics, curcuminoids, essential oil, terpinoids and flavonids present in good amounts in these extracts, whereas dichloromethane and aqueous extracts has very little capability of radical scavenging...
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Posted by admin on Aug 31, 2015 in |
The present study depicts formulation and characterization of boric acid gel formulations. The formulated gels intervenes the advantages of gels along with higher and effective antimicrobial activity when compared to the formulations available in the market. The preparations were evaluated for different parameters as basic physico-chemical properties like physical appearance, texture, pH measurement, spreadability, viscosity and spectral analysis (UV-Visible and IR Spectroscopy) for its standardization. The sharp peak at 230nm was obtained in UV-Vis spectra. I.R spectra revealed that the boric acid binds extensively to the polymers. Antimicrobial activity of formulation was studied using Muller Hinton agar medium against E.coli MTCC 614 and S.aureus MTCC...
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