Posted by admin on May 31, 2021 in |
Though the anesthesia-related death of a 15-year-old Hannah Greener marked the beginning of pharmacovigilance 160 years ago, the science of pharmacovigilance was not established as a separate field until the wake of the thalidomide tragedy in 1960’s. The World Health Organization (WHO) instituted International Drug Monitoring Program to internationalize the act of drug safety monitoring. Inspite of this, many countries, particularly the low and middle-income developing countries, found it difficult to implement a robust drug safety monitoring system in their country due to various technical and financial snags. India was able to establish its own pharmacovigilance system called Pharmacovigilance Program of India (PVPI) only in 2005. This article analyzes the hurdles and challenges faced by India during the implementation phase of the Pharmacovigilance program, and this article also compares the pharmacovigilance system of India with few other developed and developing...
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Posted by admin on May 31, 2021 in |
Diabetes mellitus is one of the most prevalent metabolic disorders and has been a leading cause of death in the last few decades. Oral hypoglycaemic agents are mostly used in the treatment of diabetes, but the main drawback of these agents is that they have some unavoidable side effects. Nowadays, researchers are mainly focusing on unexposed medicinal plant species as an alternative source for the treatment of diabetic mellitus. This review article aims to compile all the reported antidiabetic plants used by ethnic people of Assam as a folk remedy to cure diabetes mellitus and help the researcher investigate unexposed antidiabetic medicinal plants. In this concern, an extensive literature survey was carried out through different books and electronic search engines to understand the cause of diabetes mellitus and their traditional herbal remedy. Here listed 92 plant species belong to 45 families that claim ethnomedical indication to treat various diabetes mellitus. The roots, rhizomes, stems, leaves, barks, bulbs, flowers, and even the whole plant are utilized as folk remedies to...
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Posted by admin on May 31, 2021 in |
Coronavirus disease (COVID-19) has become pandemic in no time in the world. Understanding the pathophysiological similarities with previously known viruses of the class gave opportunities to explore various molecular targets against COVID-19. Vaccines unavailability propose different research approaches of treatment, including various previously known and some new synthetic molecules, which are also associated with many unwanted effects. Phytochemical compounds and formulations also gain interest in this era, and all the traditional medicine systems were analyzed for any probable therapeutic possibilities. Hence author summarize the various approaches of herbal-based medicine against COVID-19 infection. Ayurveda, Siddha, Unani, Homeopathy, and Chinese medicine systems constitute major traditional herbal-based systems known worldwide. Previous literature were studied to recapitulated findings with modern multi-mechanistic approaches and propose the use of herbals against COVID-19. Scientists are identifying all the possible interventions associated with herbal-based systems to have efficacy against various mechanisms against viral infection. Various herbal extracts and formulations are utilized to increase the human body’s immune system to counter the pathophysiological changes due to COVID-19 infections....
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Posted by admin on May 31, 2021 in |
Psoriatic arthritis is an inflammatory condition of the skin and musculoskeletal system with cutaneous psoriasis that leads to joint deformity and disability and is commonly seen in 40-50-year-old population. Clinically, TNF-α inhibitors and JAK inhibitors form the main line of treatment of this rare disorder. A systematic review was conducted via an electronic search of Google Scholar, PubMed, Science Direct, Wiley, Embase, and Cochrane databases till May 2020 using the following keywords: “Psoriatic arthritis”, “Atrophic arthritis”, “Rheumatoid arthritis”. Published literature that explores the therapeutic methods of treating CSOM are included along with data of randomized control trials (RCTs), in-vivo studies and ELISA assays are collated in this review. 43 qualitative studies from 6 databases are included in this systematic review. Of these, 40 studies depict the efficacy of chemically synthesized, nature-derived, monoclonal antibody and recombinant DNA compounds (TNF-α inhibitors, T-cell suppressors, inhibitors of MAP kinase, and JAK) and 3 studies depict the benefits of alternative agents (ZSTK474, gold sodium thiomalate nanoparticles and whole body cryotherapy) in PsA. A critical...
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Posted by admin on Apr 30, 2021 in |
Sulfonamides, sometimes called sulfa drugs, are the first drug that is largely employed and systematically essential for preventive and chemotherapeutic agents against various bacteria. Sulfonamides possess a wide range of pharmacological activities such as Oral hypoglycemic, antileprotic, anti-epileptic, anti-hypertensive, anti-bacterial, anti-protozoal, anti-fungal, antiretroviral, non-peptidic vasopressin receptor antagonists, anti-cancer, anti-inflammatory, translation initiation inhibitors, and used as a diuretic. The rapid evolution of drug-resistant bacterial and fungal infections has demanded a universal effort to search for new generation sulfonamide derivatives. The sulphonamides or sulfa drugs competitively inhibit folic acid synthesis in microorganisms and subsequently inhibit the multiplication of bacteria but do not actively kill them. These sulfonamides have a variety of synthetic reactions to work with. On the basis of the literature survey, the present review highlights research work in the recent decade, including potential antimicrobial activities of sulfonamides compounds. This review covers current advances related to synthesis and pharmacological effects of sulfonamides, especially in apprehension to anti-microbial...
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