Posted by admin on Nov 30, 2020 in |
In Today’s world, there are many drug delivery systems available but there are many problems related to drug delivery systems like stability, degradation in-vivo. Drug delivery through tablets is the most convenient method due to patient compliance. Recently, hydrogels are hydrophilic 3-dimensional polymeric structures that have been explored by researchers due to their extraordinary promising potential in a wide range of applications such as drug delivery, sealing, and tissue engineering. These 3-D polymer networks with the ability of shape deformations show a volume phase transition. The polymers used in the formulation of hydrogel have low mechanical strength and difficult to handle. Shape memory hydrogels have been extensively explored and probed; however, no amalgamated information on their effective utilization in biomedical applications is available as such. In this review article, we systematically consolidate prevailing literature and briefly enumerate shape memory hydrogels based on their principles as well as their shape transitions in diverse environments, which significantly affects operational exploitations of shape memory...
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Posted by admin on Nov 30, 2020 in |
In the development of a new drug molecule, there are many problems with respect to the dissolution, absorption, and bioavailability. Thus, formulation scientists are majorly focusing on the development of the formulation, which will increase the efficacy of the existing drugs. Oral dispersible films are one of such a novel approach. In given review article, the advantages of oral dispersible films over other oral dosage form and especially over oral dispersible tablets and their applications are discussed. In further part the major advantages regarding first-pass metabolism, disable patients, fast onset, etc., are covered. Furthermore, the overview of all the ingredients used in the formulation of fast dissolving films with the evaluation of these films is discussed in the given review article. Solvent casting, semisolid casting, hot-melt extrusion, solid dispersion extrusion, rolling are the methods which are employed, along with the evaluation parameters like thickness, tear resistance, dryness test of the prepared films are also explored in the article. This review article gives a complete overview of oral dispersible films and...
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Posted by admin on Nov 30, 2020 in |
Electrophoresis is an effective analytical tool for separation, as it does not affect the molecular structure, and it is also highly sensitive to small differences in molecular charge and size of the analytes. Capillary electro-phoresis is a separation technique where the ions are separated based on their electrophoretic mobility with an applied voltage. So far, the research field of capillary electrophoresis remains very active, as exhibited by a steady and significant flow of scientific reports on theory, separation modes, new instrumentation, and applications of CE techniques in various areas. Capillary electrophoresis is the most predominately used because it gives faster results and it provides a high-resolution separation. It is one of the useful techniques because there is a large range of detection methods available. This paper is devoted to providing a brief explanation of types of electrophoresis; capillary electrophoresis, and CE-based separation modes with some advantages and disadvantages along with applications. This paper also includes some of the hyphenation techniques based on capillary electrophoresis (CE-MS, CE-ICP-MS, CE-ESI-MS, CE-MALDI-MS, and...
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Posted by admin on Nov 30, 2020 in |
Teff millet is progressively gaining importance worldwide due to its recognition as gluten-free food. Interestingly, its attractive nutritional profile and additional functions related to maintaining health play an important role in its identification as a nutraceutical food. The present study was conducted to analyze the nutritional, phytochemical, and antioxidant properties of teff millet. Moisture, ash, fat, fiber, protein, and carbohydrate were analyzed in this study. Minerals like calcium, iron, phosphorus, and zinc were also estimated. Result on proximate analysis showed moisture (10.5 g / 100 g), ash (2.2 g / 100 g), fat (0.5g/ 100 g), fibre (2.8 g / 100 g), protein (10.9 g / 100 g) and carbohydrate (73.1 g / 100 g) respectively. Result on mineral composition showed Calcium (168.1 mg /100 g), iron (13.1 mg / 100 g), phosphorus (420.2 mg / 100 g) and zinc (4.5 mg / 100 g) were also found in teff millet. The presence of different macro as well as micronutrients was recorded in teff millet. Phytochemical analysis indicated the...
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Posted by admin on Nov 30, 2020 in |
From ancient times, herbal medicines are in use to cure the diseases due to their impending and less side effects. But complications in identification, processing, standardizing, extracting of herbal drugs, it seldom attracts scientists towards the development of novel delivery systems for herbal drugs. During drug development, the complete knowledge of novel scientific approaches like toxicity study, OECD guidelines, pharmacokinetic, drug and cosmetic act as well as different types of formulation are necessary to understand. Here, we have tried to compile all the drug preparation methods in brief. Nanoparticles are in the solid state and are amorphous or crystalline. They are capable to absorb and/or encapsulate a drug in large amount with increased pharmacodynamic and pharmacokinetic action. Thus protecting it against chemical and enzymatic degradation Also, given some information about types of diabetes and its pathophysiology. In advanced novel drug delivery system microspheres playing a very vital role having maximum loading capacity and are easily formulated with natural as well as synthetic...
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