Posted by admin on Oct 31, 2020 in |
Discovery of New Chemical Entities (NCEs) is the result of a series of high throughput screening process after the successful design and synthesis scheme. The indole nucleus is an important heterocyclic compound containing nitrogen, and it has been a source of vital therapeutic agents. It is noteworthy in recent advances of synthetic, medicinal chemistry; the last decade has been witnessed with a multitude of reports on several indole derivatives corroborating these chemical entities to be an eminent target for the discovery of new drugs. Global research investigations published has outstanding impact attention for the scientists working on indole derivatives which transformed into various commercially approved indole candidate in the commercial market and there are several in the pipeline. This review highlighted recent achievements of indole lead molecules in biological, chemical, and pharmacological activity having diverse perspectives on how this indole moiety as a privileged structure may be browbeaten for elucidating salubrious biological...
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Posted by admin on Oct 31, 2020 in |
Although serious systemic and cutaneous side effects need a novel delivery system that provides prolonged and controlled drug release, minimum systemic drug absorption with reduced side effects. Microsponge, a drug delivery system, possesses the versatility to load a wide range of active ingredients to facilitate the controlled release of active ingredients to reduce systemic exposure and to reduce side effects. Microsponges are polymeric sponges that consist of interconnecting voids with a non-flexible structure with a porous surface. Microsponge delivery technique provides extended product stability, enhanced safety, enhanced formulation flexibility, enhanced product efficacy, enhanced aesthetic appeal with reduced side effects. Therefore, this review provides an overview of microsponge technology with its methodology, mechanism, programmable release, and characterization of the microsponge delivery system. Review compiled recent data regarding marketed formulation, their applications, and the list of patents. This review also contains validation, stability guidelines, and examples of drug release profiles from microsponges. Microsponges are frequently used for topical use but recently used for oral...
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Posted by admin on Oct 31, 2020 in |
“Eat to live and don’t live to eat” this is a principle to be followed for a healthy and wealthy life. According to the therapeutic point of view, the patient who suffers from peptic ulcer diseases was shown to have a reduced secreted amount of HCl and pepsin. The management of gastric and duodenal ulcers can be followed by the decreased or neutralized level of gastric acid. Peptic ulcer influences up to 10% of the all-out total populace accordingly called chronic disease. Peptic ulcer arrangement relies on the lessening in the mucosal guards and on the nearness of the gastric juice pH. The two central points which disturb the mucosal protection from damage is the Helicobactor pylori (H. pylori) contamination and Non-steroidal calming drugs (NSAIDs). The valuable medicines of peptic ulcer are Proton pump inhibitors, Histamine-2 (H2) receptor antagonists, Antacids, Anticholinergics, Mucosal defensive agents, Bismuth compounds, Antimicrobial agents, and cholecystokinin-2-receptor antagonists drugs. The review contains the detailed study of H2 receptor antagonist drugs used as anti ulcers and the...
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Posted by admin on Oct 31, 2020 in |
Psoriasis is a chronic inflammatory disease that affects about 1-2% population. It is caused by different factors, the most common cause being genetic predisposition. Other causes or factors that can trigger psoriasis include infection, physical trauma to the skin, stress and certain medication, for example, beta-blockers and antimalarials. People suffering from psoriasis are at a greater risk of developing psoriatic arthritis, anxiety, depression, and cardiovascular diseases. Psoriasis can affect the quality of life of the patients and can result in financial problems as repeated treatment is required. Nowadays, people now opt to make use of natural remedies alone or in conjunction with conventional therapy to improve their condition. In this review article, natural remedies that have proved to have antipsoriatic activity have been summarized. These natural sources can be a source of bioactive compounds that have a potential to treat and manage...
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Posted by admin on Oct 31, 2020 in |
The mitogenic activity in earthworms should be accompanied by antioxidative and antimicrobial activities during the healing or regeneration of their amputated part. These activities are achieved by bioactive macromolecules in their tissue and coelomic fluid. The antioxidative activity applied to prevent the cellular function from oxidative damage and assist cell multiplication. The antimicrobial activity prevents the wounded area from bacterial infection and enhances cell division. This review aims to promote cheap natural products of earthworms to be used widely in human medicine. Thus, we reviewed how to extract coelomic fluid, preparation of tissue homogenate (G-90) and application of mitogenic, antioxidative, antimicrobial activities on experimental animal rats, mice and rabbits. These products were efficient for hasty wound healing, the proliferation of damaged bone, boosting of immune cells and nerve cell regeneration without carcinogenic and mutagenic characteristics. Therefore, the biotechnological application of tissue homogenates and coelomic fluid should get due...
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