Posted by admin on Sep 30, 2020 in |
Nanosuspension consists of a submicron colloidal dispersion of pharmaceutically active ingredient particles in the liquid phase, which is stabilized by surfactant. Poor water solubility is a major problem for the manufacturing of formulation. The drug particle reduces leads to enhance the surface area as well as bioavailability. Nanosuspension prepared by way of a number of methods. Techniques such as media milling, high-pressure homogenization have been used commercially for producing Nano-suspension. Recently engineering of nanosuspension employs emulsion and microemulsion as a templet. The unique feature of Nanosuspension has enabled its use in different dosage forms and delivered by using various routes such as an oral, pulmonary, ocular, topical, and mucoadhesive hydrogel. The benefits of nanosuspensions are improved drug dispersibility and drug solubilization, improved therapeutic efficacy and reduced toxicity. Therefore, the present review described the achievements of nano-suspensions in the drug delivery system in order to enhance the solubility, stability, and bioavailability of the drugs. This review article describes the preparation methods, characterization, and applications of the...
Read More
Posted by admin on Sep 30, 2020 in |
About 1.5% of the world’s population is suffering from Parkinson’s disease, mostly above 55 years of age. It is identified by dopaminergic neuron loss in the striatum’s Substantia nigra & dopamine loss (DA). The disease of Parkinson is the second most widespread neurodegenerative disorder. It adversely affects the motor system as the disease increases the destruction of the motor system. It is also known that it also affects almost other components of the brain, but slowly. By using these animal models, we got to know the process of PD, its etiology, its pathology, molecular mechanisms, and numerous other disorders. Experimental models are carried out using theses different agents such as reserpine, 6-hydroxydopamine, haloperidol, 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine, and rotenone when used to produce particular PD characteristics. In addition, genetic models are also used to understand the processes in multicellular organisms such as drosophilia and zebrafish. Behavioral studies have been conducted mainly using these multicellular...
Read More
Posted by admin on Sep 30, 2020 in |
Over the previous decade, several drug delivery systems have come into view, and an alluring part of this is the advancement of nanoparticle systems. Lipid drug delivery systems has considered as one of the emerging technologies and obtained attention due to features like biocompatibility, lipophilic characteristics. Among nanoparticle Nanostructured lipid carriers (NLC) have numerous advantages than emulsions, liposomes, microparticles, and solid lipid nanoparticles (SLN). NLC is a second-generation nanoparticulate system and has solid nature at ambient temperature. It comprises mainly of solid lipid, liquid lipid, surfactants, and water. It is approved by regulatory authorities to use as drug delivery systems. Due to ease in formulation, the practicability of large scale production, biocom-patibility of components used, non-toxicity, and improved targeting efficiency, NLC has a number of applications in the cosmetic industry and pharmaceutical industry. This review highlights its types, the various formulation techniques, and evaluation techniques. The review also provides an application of NLC as a targeted delivery...
Read More
Posted by admin on Sep 30, 2020 in |
Zoonoses are human diseases caused by animal pathogens or animal diseases that are transmissible to humans. They are caused by all types of pathogenic agents, including bacteria, parasites, fungi, viruses, and prions. Zoonotic diseases can be transmitted to humans by infected saliva, aerosols, contaminated urine or feces, and direct contact with the animal or pathogenic microbes. Furthermore, transmission can also occur through animal vectors (e.g., tick bite, and insects like mosquitoes or flea). The zoonotic microbes continue to evolve and adapt with tremendous acceleration and expansion of global trade, human movement, and population. Control of zoonotic diseases and protection of public health are challenging tasks as the world population is increasing proportionately. Newly emerging viruses such as the Ebola virus, severe acute respiratory syndrome (SARS)-, Middle East respiratory syndrome (MERS)-coronavirus, and the avian influenza virus, H1N1 virus, Nipah virus, Zika Virus, and now Covid-19 are serious threats to public health and have become a global concern. The prevention of these infections depends on improved diagnosis and highly effective therapeutics/...
Read More
Posted by admin on Sep 30, 2020 in |
In the era of recent technology, robotic surgery will be the ruler of the medical world with its attributes, its journey from a mere idea to today’s world’s surgical epitome. Using the methods of telerobotic visualization and controlling systems, this technology works towards improvement in all the fields of medicine and patient care. Robotic surgery dwells on the functionality of the most widely known models of Da Vinci and Zeus. It has benefited the patients by combining with minimally invasive, transoral, and laparoscopic techniques working better in synergism. It has been to date employed in the surgeries in the fields of the eyes, cranium, bone, thyroid, heart, liver, obesity, gastrointestinal, obstetrics as well as carcinomas. Its future potential is bright based on the types of technologies that are being linked with normal robotic surgery. One such endeavour is the microbot, which makes reaching the smallest nooks and corners of the internal physiology of the human body possible as well as more...
Read More
