Posted by admin on Feb 1, 2014 in |
Diabetes mellitus (DM) is a metabolic disorder of the endocrine system. This frightful disease is found in all parts of the world and is becoming a serious threat to healthcare providers. Nowadays DM is a most spreading disease in the world. In rapidly growing world a number of treatment options are available for treatment of DM. Long term use of allopathic medicinal agents may cause unwanted side effects, resulting uncontrolled blood sugar as well as complications of DM, also DM is highly prone to different types of microorganism and it will affect immune system of body. The use of herbal medicine for the prevention and treatment of DM has been in practice since ancient time. Medicinal plants as a traditional medicine is being used by about 60% of the world’s population and India is major contributor to produced herbal medicines. Generally it is believed that the risk associated with herbal medicine is very less, but reports on serious reactions of herbal drugs are also necessary. Numerous herbal plants have...
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Posted by admin on Jan 14, 2014 in |
A large no of synthetic and natural compounds behave as very effective drugs. All these compounds have a wide range of biological activities like anti-bacterial, anti-fungal, anti-cancer, anti-viral, anti-inflammatory, anti-neoplastic, anti-tumorigenic, anti-HIV and so on. On the other hand, metals have played an important role in medicine for years. Many are essential in our diets in varying quantities. In addition to the metalloantibiotics, a number of drugs and potential pharmaceutical agents also contain metal-binding or metal-recognition sites, which can bind or interact with metal ions and potentially influence (increase or decrease) their bioactivities. In this review changes in drug potentiality upon interaction of metal ions with some natural and synthetic drugs have been discussed. Different metal ions which are toxic at higher concentrations are also useful for maintaining life processes at lower concentrations and are even effective in the modification of some well established drug molecules towards their better action. The alkaline earths and transition metal ions are the most thoroughly studied amongst...
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Posted by admin on Jan 1, 2014 in |
Early introduction of complementary foods (weaning) before 4 to 6 months of age and unmodified cow’s milk before age 12 months are associated with several health risks in children. Too early introduction of unmodified cow’s milk and milk products to infants and toddlers has adverse effects on their iron stores. Children can develop iron-deficiency anemia from chronic enteric blood loss even when occult blood is not found in stools on random testing. Several mechanisms have been identified that may contribute to iron deficiency anemia in young population group. The most important of these is probably the low iron content of Cow’s Milk. Other risks in association to the consumption of unmodified cow’s milk in infants include increased renal solute load; increased blood loss from the gastrointestinal tract, chronic constipation, and anal fissures; and an increased risk for subsequent type 1 and type 2 diabetes. Evidence is now also growing to show that iron deficiency anemia is associated with developmental delay, and that the association is causal. Breastfed infants may...
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Posted by admin on Jan 1, 2014 in |
Cancer is a complex disease occurring as a result of a progressive accumulation of genetic aberrations and epigenetic changes that enable escape from normal cellular and environmental control. Cancer is treated with surgery, radiation, chemotherapy, hormones and immuno-therapy. But, due to side effects such as toxicity, death of normal cells near to cancer cells, second formation of cancers; these treatment was not successful. Targeted gene therapy is the most acceptable for cancer treatments because the above shortcomings overcome by it. Targeted therapy refers to a new generation of anticancer drugs that are designed to interfere with a specific molecular target, usually a protein with a critical role in tumor growth or progression. This approach differs from the more empirical approach used in conventional cytotoxic chemotherapy, which has remained the mainstay of anticancer drug use over the past several decades. Targeted therapy has the potential to reduce or eliminate many of the present problems in the field of cytotoxic chemotherapy, such as the production of serious host-cell toxicity. Several types...
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Posted by admin on Jan 1, 2014 in |
Indian literatures like Ayurveda and various ancient literatures have stated herbal remedies for a number of human ailments. Annona reticulata which is commonly known as bullock’s-heart in English and Ramphal in Hindi and Marathi is having various pharmacological activities such as antioxidant, anticancer, analgesic and CNS depressant, antimalarial, anthelmintic, in syphilis and few more. Some compounds have been isolated and reported from the extract of various parts of the plant possessing good pharmacological activity. The studies performed on the seed and root extract also evidenced that the same compounds causes cell death in various cancer cell lines. This review article is a sincere effort to put forward the medicinal importance and botanical, phytochemical, pharmacological details of the...
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