Posted by admin on Jul 31, 2014 in |
The present investigation carried out in six villages of Almora district of Kumaun Himalaya regarding mild and native ethno-medicinal plants which were used by locals in their own traditional health care system. This study reveals the status of ethno-medicinal plants and their importance preserved by locals of Kumaun region. During the study it was observed that 47 species of medicinal plants belonging to 38 genera and 28 families were being used in ethno medicine by locals with advice of Vaidhyas and experienced persons of the region since long time. The main purpose of this study was to document the indigenous knowledge of Vaidhyas and other experienced persons of the area regarding the use of ethno-medicinal plants, their conservation and imparting this knowledge with younger generation. Because, the indigenous knowledge of local flora are being eroded in younger generation, therefore the present study may help in fulfill this gap...
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Posted by admin on Jul 31, 2014 in |
Many water insoluble drugs present in class 2 and it is characterized by low solubility and high permeability. Solubility of drug can be enhancing by increasing of dissolution rate. Many solubilization techniques are available for increasing of solubility as well as permeability like micronization, coacervation, complexation, solid dispersion, and cosolvent. Poorly soluble and dissolution profile creates problem in pharmaceutical industry for development of dosage form. Solid dispersions are the most attractive method for improving of bioavailability of poorly water soluble drugs. Reduction of particle size leads to increase in wettability and porosity of drugs. Porosity and wettability improves the solubility and dissolution...
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Posted by admin on Jul 2, 2014 in |
In the recent years, scientific and technological advancements have been made in the research and development of novel drug delivery systems by overcoming physiological troubles such as short gastric residence times and unpredictable gastric emptying times. Gastric emptying of dosage form is extremely variable process and ability to prolong and control the emptying time. Gastric transit time is valuable asset for dosage forms, which reside in the stomach for a long period of time than conventional dosage form. Several approaches are currently utilized in the prolongation of the gastric residence times, including floating drug delivery systems, swelling and expanding systems, polymeric bioadhesive systems, modified-shape systems, high-density systems and other delayed gastric emptying devices. The purpose of writing this review on floating drug delivery systems (FDDS) was to compile the recent literature with special focus on the principal mechanism of floatation to achieve gastric retention. This review explains briefly about types of floating system, advantages, limitation, floating mechanism, factors affecting floating system, drug candidates suitable for floating, evaluation parameters and...
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Posted by admin on Jul 2, 2014 in |
Meningitis is a condition whereby the protective membranes covering the central nervous system (or meninges) become inflamed. Infections of the central nervous system are still considered to be among the most debilitating diseases in the 21st century. The mortality from this infection ranges from 15% in industrialized to 40% in developing countries. Streptococcus Pneumoniae infections, including pneumococcal meningitis, are therefore likely to remain an important health issue. Pneumococcal meningitis in human beings is associated with long-term sequelae including sensory-motor deficits, seizures, and impairments of learning and memory. Neurological sequelae occur in up to half of the survivors of pneumococcal meningitis. Meningitis is manifested as severe headache, occurring in almost 90% of cases of bacterial meningitis, followed by nuchal rigidity. Meningitis is a potentially serious condition due to the proximity of the inflammation to the brain and spinal cord. The potential for serious neurological damage or even death causes meningitis to need immediate medical attention and...
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Posted by admin on Jul 2, 2014 in |
Saliva plays the most important role in the maintenance and preservation of the health of our oral cavity. In diabetes mellitus functions of salivary glands are impaired and as a consequence xerostomia develops. Hoposalivation leads to various oral mucosa alterations, ulcerations, taste alterations, burning mouth, dental decay, halitosis and various infections. All these alterations can compromise patient’s quality of life. Saliva can also be used as a diagnostic tool as well as marker for monitoring diabetes...
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