Posted by admin on Aug 31, 2023 in |
Thrombosis is one of the major causes of death and disability worldwide. Cancer patients are commonly thrombophilia or prothrombotic since they have abnormalities in all three factors of Virchow’s triad, which lead to thromboembolism. Venous thrombosis (VT) is a chronic disorder that has the potential to be fatal and cause considerable complications. Venous thromboembolism (VTE) may potentially be the first indication of an undetected cancer in individuals. The rate of VTE and the risk of complications are much higher in the cancer patient groups. Arterial thrombosis is more likely to form when the plaque on the wall of the arteries consists a significant quantity of lipids covered by a layer of connective tissue. Thrombus formation in arteries may result in a heart attack or stroke. The hemostasis phase (liquid blood quickly hardens and forms a clot following injury to the blood vessel wall) spirals out of control. As a result, many blood clots form in the blood vessels that provide blood to various organs. Patients display paradoxically both excessive...
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Posted by admin on Aug 31, 2023 in |
Oral route is the easiest and most convenient route for drug administration more than 40% of new chemical entities exhibit poor aqueous solubility, resulting in unsatisfactory oral drug delivery. Self-nano-emulsifying drug-delivery systems (SNEDDSs) are one of the emerging strategies developed to tackle the issues associated with their oral delivery. SNEDDSs are composed of an oil phase, surfactant, and cosurfactant or cosolvent. SNEDDSs characteristics, their ability to dissolve a drug, and in-vivo considerations are determinant factors in the choice of SNEDDSs excipients. SNEDDS is a proven method for enhancing solubility and bioavailability of lipophilic compounds. Considering the ease of large-scale production and the robustness of SNEDDS, several formulations techniques are commercially available. The review provides exhaustive insight about the potential of SNEDDS in improving bioavailability of poorly soluble...
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Posted by admin on Aug 31, 2023 in |
This review aims to provide a brief overview of different mechanisms involved in the pathophysiology of asthma, a variety of cells, and mediators released from these cells, which have an important role in the pathophysiology of asthma. Asthma is a heterogeneous disease which having complex pathophysiology and affects many individuals. Asthma is an inflammatory disease in the airway, leading to airway hyperresponsiveness, obstruction, mucus hyper-production, and airway wall remodeling. Status asthmatics is characterized by hypoxemia, hypercarbia, and secondary respiratory failure. The structural, mechanical, and inflammatory abnormalities related to asthma and the different mediators like histamine, cytokines, leukotrienes, thromboxane’s inflammatory cells eosinophils, mast cells are important in asthma pathophysiology. TGF-h and IL-11 are the main cytokines that are involved in airway remodeling. Mast cells are responsible for initiating inflammatory responses after exposure to allergens and the resulting immediate bronchoconstriction. Macrophages releasing the mediators may be responsible for amplifying the inflammatory process. Dendritic cells act as antigen-presenting cells and play a role in the chemotaxis of T cells. Eosinophils are a...
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Posted by admin on Aug 31, 2023 in |
Obesity is related with a number of metabolic difficulties, growing obesity may disrupt hormonal and metabolic systems, which may lead to the body storing extra energy in a variety of forms. The amount of total energy the body has stored as fat is negatively associated with the rate at which leptin circulates in the bloodstream, which is predominantly produced by adipose tissue. It is widely accepted that central serotonin contributes to the inhibition of hunger in mammals and recent reviews have elucidated the mechanisms behind these effects. The hypothalamus regulates hunger as well as energy homeostasis. The digestive tract and adipose tissues are just two examples of peripheral afferent signals that complex brain networks combine to create efferent responses that regulate food intake and energy use. Origin of ghrelin in the circulation is the abdomen and gut. Dopaminergic circuits are used to control intake of food, according to research on human brain imaging. According to the carbohydrate-insulin paradigm, adipose tissue’s endocrine dysregulation rather than acting as a passive fat-accumulator...
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Posted by admin on Aug 31, 2023 in |
Iriflophenone 3-C-β-D glucoside is a Benzophenone derivative which can be obtained from various plant sources like Aquilaria crassna, A. sinensis, A. malaccensis, Cyclopia genistoides, Mangifera indica, Dryopteris ramosa etc. It can act as an important herbal active constituent as it has various pharmacological actions, such as Antidiabetic, anti-inflammatory, antioxidant, and antimicrobial agent. Some scientists demonstrated the antioxidant activity of Iriflophenone 3-C-β-D glucoside and have seen that this compound has no radical scavenging ability against DPPH [2,2-diphenylpicrylhydrazyl] but scavenged ABTS [2,2’-azino-bis(3- ethylbenzothiazoline-6-sulphonic acid)] and peroxyl radicals. So, it can be used as an anti- oxidant agent. From A. sinensis 8 compounds were isolated among which Iriflophenone 3-C- β-D glucoside was present. It is proved that all the isolated compounds have α-glucosidase inhibition activity stronger than acarbose, that is taken as positive drug control. Aqueous fraction of D. ramosa is used for so long by the inhabitants of the Galliyat region of Pakistan to treat their GIT ailments caused by bacteria. Scientists showed that Iriflophenone 3-C-β-D glucoside that is obtained from...
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