Posted by admin on Jan 31, 2024 in |
Cubosomes are square and rounded particles with internal cubic lattice. Cubosomes are thermodynamically stable and consist of honeycombed (cavernous) structures separating two internal aqueous channels and a large interfacial area. Cubosomeisa novel biocompatible drug delivery system whose diameter size range from 10–500 nm. Cubosomes possessa great significance in the field of cosmeceuticals and Pharmaceuticals due to their unique features and become an attractive choice of vehicle for in-vivo drug delivery due to their low cost, safety, efficacy, and versatility for controlled release application and functionalization. Cubosomes have a very simple method of preparation. Cubosomes are nanoparticles that are self-assembled liquid crystalline particles of certain surfactants with a proper ratio of water with a microstructure that provides unique properties of practical interest. The word bicontinuous refers to the division of the two continuous but non-intersecting aqueous regions by a lipid bilayer that is twisted into a space-filling structure. The controlled release application of these nanoparticles is of great significance in cosmeceutical and pharmaceutical fields, and they can be characterized by...
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Posted by admin on Jan 31, 2024 in |
Introduction: Therapeutic agent must be compatible with its target. Their multiple interaction produces diversified therapeutic action. Chemical exploration of phytoconstituents unravels bio–interaction and strategic engineering of molecules generates wonderful leads in therapeutics. Method: The source of information has been accessed through multiple research and review article of peered journals. The logical mechanics has been putted to churn the spread about phyto therapeutics of natural and its semi–synthetic derivatives. Result: For developing and designing a receptor/target compatible structure, chemical diversity of plants provides very good source to have a potent and effective therapeutic agent. Study of natural chemical templates helps not only to understand bio–mechanism but also creates a different approach of treatment. This review targets different diseases with natural compounds with enlighting the semi–synthetic analogues study of some of them. Exploring the chemistry/various character of molecule may provide a better fit model with minimal or no side effect. Discussion: On the basis of data processed phytotherapeutics may be explored upfront in pharmaceutical industry. These phyto magical entities presenting the...
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Posted by admin on Jan 31, 2024 in |
The healing homes of plant life have been identified because time was immemorial. Many pathological conditions have been handled using plant-derived drug treatments. Recent advances in analytical and computational strategies have opened new avenues to technique complex natural merchandise and to use their structures to derive new and revolutionary drugs. Indeed, we’re in the era of omics as applied to herbal products. Predictive computational software programs have contributed to the invention of molecular targets for natural products. The rapid adoption of omics procedures to research facts using genomics, transcriptomics, proteomics, and metabolomics has opened a new manner toward natural drug discovery. The records of omics, the technology utilized in omics gear, role of omics in natural drug discovery, its strengths and challenges of omics equipment are discussed in this...
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Posted by admin on Jan 31, 2024 in |
The solubility problem of drugs is always one of the most challenging aspects in formulation and development of dosage forms. In fact, most of new chemical entities are poorly water soluble and not well-absorbed after oral administration resulting in low bioavailability. The current challenges of the pharmaceutical industries are related to techniques that improve the water solubility of drugs. Solid dispersions are one of the most successful strategies to enhance the oral bioavailability of poorly water-soluble drugs by reducing particle size and improving drug wettability. This article reviews various types of solid dispersion, and their preparation techniques. Some of the practical aspects to be considered for the preparation of solid dispersions are selection of carrier and methods of physicochemical characterization thorough study of nature of drug in solid dispersion etc. are discussed. At the end of the article commercialization of some solid dispersion and recent revival has been considered. This article gives scope for research in enhancement of solubility of poorly water-soluble...
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Posted by admin on Jan 31, 2024 in |
Various bioactive aromatic compounds containing the indole nucleus showed clinical and biological applications. It has the unique property of mimicking different structures of proteins and binding to enzymes in a reversible manner. Indole scaffold has been found in many of the important synthetic drug molecules which gave a valuable idea for treatment and binds with high affinity to the multiple receptors helpful in developing new useful derivatives. Indole derivatives possess various biological activities, i.e., antiviral, antifungal, antidiabetic, anti-inflammatory, anticancer, antifertility, anti-HIV, antioxidant, antimicrobial, antitubercular, anticonvulsant, antimalarial, anticholinesterase activities, etc. which created interest among researchers to synthesize a variety of indole derivatives. This review focussed on recent developments of indole derivatives having different pharmacological profiles as well as different perspectives on how this indole moiety as a privileged structure may be exploited in the...
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