Posted by admin on Nov 30, 2015 in |
In the present studies was designed to evaluate oral compression coated tablet formulation to achieve time and site specific drug release system to target lower GIT. A pectin based compression coated tablet formulation of different ratios and concentration of ethyl cellulose and cellulose acetate phthalate were designed and evaluated physico chemical parameters and for tinidazole release, compression coated tablet formulation 7.5% : 7.5% ethyl cellulose: cellulose acetate phthalate showed controlled drug release, were formulation showed no evidence of drug release in pH 1.2, but drug released was in simulated intestinal fluid pH 7.4 after 5 hours, further drug release continued in pH 6.8 i.e. pH of colon for 24 hours and was 87.38% after 24 hour, suited for colon specific drug delivery, on subjecting the selected formulation to in vitro microbial disintegration studies, the disintegration started within 4 hours of incubation period indicates that the usefulness of pectin in the formulation, were pectin is microbially hydrolysable and complete disintegration was observed after 16 hours. In vivo oral disintegration/ degradation...
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Posted by admin on Nov 30, 2015 in |
Exposure to hypobaric hypoxia differentially affects physical performance and survival amongst individuals. The present study was designed to investigate the role of metabolic enzymes, antioxidants and bioenergetics molecular markers in the differential hypoxic tolerance of animals exposed to acute hypobaric hypoxia and the effect of herbal supplementation in augmentation of hypoxia tolerance. Adult rats were categorized as susceptible (<10 min), normal (10-25 min) and tolerant (>25min) on the basis of time taken for onset of gasping when exposed to a simulated altitude of 9754 m (~205 mm Hg). Animals susceptible to hypoxic stress showed significantly higher levels of reactive oxygen species and malondialdehyde, concomitant with lower endogenous antioxidants viz. superoxide dismutase (SOD) and catalase (CAT) levels. These groups of animals also showed increased lactate dehydrogenase activity. Conversely, tolerant animals displayed enhanced antioxidants (SOD, CAT and GSH), citrate synthase (CS) and glucose-6-phosphate dehydrogenase (G6PD) activities. Hypobaric hypoxia up-regulated the expression of key signaling proteins involved in energy metabolism viz. hypoxia inducible factor-1α (HIF-1α), AMP-activated protein kinase-α (AMPKα) and glucose transporter4...
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Posted by admin on Nov 30, 2015 in |
In situ forming polymeric formulations are drug delivery systems that are in sol form before administration in the nasal cavity, but once administered, undergo gelation in situ, to form a gel. The formation of gel depends on factors like temperature modulation, pH change, presence of ions and ultra violet irradiation, from which the drug gets released in a sustained and controlled manner. In the recent years, nasal route has been identified as promising drug delivery route for systemic therapy. Mucoadhesive in situ gel formulations have demonstrated increase in the residence time in the nasal cavity as well enhancement of the permeation characteristics of the drug. The in situgel forming polymeric formulations offer several advantages like sustained and prolonged action in comparison to conventional drug delivery...
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Posted by admin on Nov 30, 2015 in |
The present study evaluates antidiabetic effect of A. indica leaf extract (AILE) and A. indica bark extract (AIBE) on antioxidant enzymes in the brain of alloxan diabetic rats and compared with insulin treatment. The oral effective dose of A. indica leaf (500mg/Kg body weight) and A. indica bark (100mg/Kg body weight) was given once daily for 21days to separate groups of diabetic rats. At the end of the experimental period, blood glucose levels and activities of superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), glutathione reductase (GR) and glucose-6-phosphate dehydrogenase (G-6-PD) were measured in cytosolic fraction of whole brain. Lipid peroxidation levels were measured in the blood plasma and brain of all the treated diabetic groups. Diabetic rats showed high blood glucose (p<0.01). Decreased activities of SOD, CAT, G-6-PD (p<0.05) and increased activity of GPx, GR were observed in diabetic rats brain. Diabetic controls showed significant increase in MDA level in brain tissue (p<0.05). Treatment with insulin, AILE and AIBE restored the above altered parameters close to the control...
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Posted by admin on Dec 1, 2014 in |
Rheumatoid arthritis is a major ailment among autoimmune disorders. A large number of herbal extracts were used for the treatment of various types of rheumatoid disorder. The leaf and root of Justicia gendarussa belonging to Acanthaceae family, commonly known as Nilinirgundi is traditionally used for chronic rheumatism. The present study deals with in-vitro anti-arthritic activity in pharmacological models were studied such as inhibition of protein denaturation and trypsin (proteinase) inhibitory activity. Different fractions and isolated compound from methanolic extract of leaf and root of J.gendarussa with different concentrations (10,100,1000µg/ml ) were studied and results were compared with standard drug Indomethacin. The methanolic extract of leaf and root of J. gendarussa showed dose dependent activity which was found comparable to that of standard drug Indomethacin. Isolated compound-La of leaf of J. gendarussa inhibited the activity of trypsin with IC50 values 34.85 µg/ml as compared to standard drug Indomethacin with IC50 value 11.57 µg/ml. Compound-La of leaf of J. gendarussa showed protein denaturation inhibition at the IC50 value of 24.74 µg/ml...
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