Posted by admin on Nov 30, 2022 in |
In order to discover new treatments for a wide range of ailments, ethnopharmacological research has investigated different leads from plants. In nature, the Orchidaceae family’s Vanda roxburghii is found in Bangladesh and India. As a remedy for dyspepsia, bronchitis, and inflammations, as well as for rheumatoid arthritis and bronchitis, various portions of the plant are employed. A number of the plant’s beneficial compounds have been identified, including alkaloids, glucosides, fatty acids, saponin, and tannin compounds, as well as β- and γ-sitosterols, as well as fatty oils, resin, and tetracosylferrulate in the roots. In the angiosperm family, orchids make up the largest and most diversified group. They are grown for their magnificent blooms. Flowers of all sizes, shapes and colors can be found on these plants. However, these plants have been widely recognized for their economic relevance, but little attention has been paid to their medical properties. Ayurvedic practitioners have long relied on orchids to treat a wide range of diseases. For centuries, people have relied on the herb to...
Read More
Posted by admin on Nov 30, 2022 in |
Background: Hypertension is the most common disorder affecting different age groups of people. The increased blood pressure creates discomfort in the patients; these cardiovascular diseases are risky which can lead to “mortality and morbidity”. Labetalol hydrochloride is an anti-hypertensive drug used to treat high blood pressure and Angina. These compounds possess less water solubility and low bioavailability (25%). Objective: The current study is aimed to develop Labetalol hydrochloride Liquisolid Tablets to enhance its solubility. Results: The in-vitro dissolution studies showed enhanced drug release at 98.43% with Avicel PH102 as carrier and 96.54% with Fujicalin as the carrier. Hence F3 with 98.43% drug release was considered the optimized formulation. The optimized formulation batch F3 was subjected to stability studies as per the ICH guidelines. There was no significant change observed. Conclusion: It can be concluded that labetalol hydrochloride was successfully incorporated as a liquisolid tablet by the direct compression method. The direct compression method employed was easy and can be widely used’. The powder blend of F3 containing avicel pH...
Read More
Posted by admin on Nov 30, 2022 in |
Plants have been utilized as medicine since the ancient period, and they are at the basis of much of modern medicine. Plants provide the basis for many conventional medications and the majority of the few successful drugs. Herbal formulations are becoming increasingly popular nowadays. But in some cases, side effects of the herbal formulations have been reported. So, according to the AYUSH ministry, herbal formulations should also be evaluated for toxicity to determine their safe dose. This study aims to critically assess the scientific evidence for herbal formulations’ acute and subchronic toxicity. Six herbal formulations of Shree Dhanwantri Herbals were tested for toxicity in rats. An acute and subchronic toxicity study was conducted on Wistar rats following OECD-423 and OECD-408 guidelines, respectively. No mortality or abnormal behavior was observed in the acute toxicity studies. In the sub-chronic toxicity study, testing formulations did not produce any significant changes in rats’ behavior compared to the control group. Further, hematological and biochemical parameters were also found normal. Histopathological analysis revealed that treated...
Read More
Posted by admin on Nov 30, 2022 in |
A metabolic disease called diabetes mellitus in which blood glucose levels are abnormally high. It could be due to tissue glucose intolerance and impaired insulin production. In a Type II diabetes model generated by Streptozotocin and nicotinamide, the antidiabetic potential of ethanolic and aqueous leaf extracts of Michelia champaca (Magnoliaceae) was compared to a control group of diabetes. The anti-diabetic activity was tested on Wistar rats. The effective antihyperglycemic ethanolic and aqueous leaf extracts were tested at two doses of 250 mgkg-1 b.w. and 500 mgkg-1 b.w. for 21 days. Compared to the diabetic control group, the ethanolic extract at a dose of 500 mgkg-1 b.w. exhibits a highly significant (p<0.001) reduction in fasting blood glucose levels. After the trial, the blood sample was drawn from all animals for biochemical analysis. In extract-treated diabetic rats, the serum lipid profile was calculated. The biochemical investigation, serum cholesterol, serum triglyceride, high-density lipoprotein, and low-density lipoprotein support the ethanolic extract’s anti-diabetic...
Read More
Posted by admin on Nov 30, 2022 in |
The herbal medicines have been largely used since form several thousands of years in all developing and developed countries in the primary health care of community and society. Flavonoids are the class of polyphenolic secondary metabolites, which are mainly found in plants. Apigenin is a flavonoid which shows several pharmacological activities and used effectively for the management and treatment of several diseases and disorders. Many herbal medicines and their preparation containing Apigenin are available in market and hence Quality Control and standardization of Apigenin is important and essential in ayurvedic industries. The scientific research articles published on analytical development and validation of Apigenin and its estimation in its extract, isolated form and other herbal or polyherbal formulations were reviewed. We have mainly focused on chromatographic and spectroscopic techniques for qualitative and quantitative analysis of Apigenin and presented in this review work. We conclude here that the spectroscopic and chromatographic methods play significant role in the quality control and standardization of Apigenin in herbal...
Read More
