Posted by admin on Nov 30, 2018 in |
As in the cases of non-communicable but chronic and autoimmune disorders like diabetes, cancer, anemia and rheumatoid arthritis are growing threat to humans. They depend on the genetic information and the genome sequence of the patients and other factors like environmental factors. In most of the cases, the pattern of the disease, i.e. pathogenesis is different for every individual, though phenotypic expression is same. Hence, there is a greater risk for the patient having the genes which are likely to cause above mentioned diseases and side effects or adverse drug reactions due to the therapy available. This occurs due to only one reason that every individual will not react to a drug in a same way. For minimizing these unwanted side effects or adverse reactions which are disease related and for giving patients a better and a bit healthy life, personalizing the medication is essential. This personalization involves the study of phenotypic and genotypic information of the patient and then planning the 3D’s i.e. choice of drug, dose and...
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Posted by admin on Nov 30, 2018 in |
Salicylic acid is a phenolic plant growth regulator found in plants with various important physiological roles. This investigation was aimed to study the effect of exogenous application of salicylic acid on the growth, metabolism and health status of Mentha spicata, an aromatic medicinal plant having several monoterpenes and antioxidants which show various kinds of medicinal properties. In the present work, some growth and biochemical parameters were recorded at 30 and 60 days after treatment with different concentrations of salicylic acid (0, 100, 200 and 300 µg ml-1). Results clearly revealed that salicylic acid particularly at 200 µg ml-1 concentration significantly enhanced most of the growth and some of the biochemical attributes as well as the antioxidant property when compared with that of control plants. It can be concluded that exogenously applied salicylic acid at particular doses can enhance the biomass production as well as the medicinal potential of M. spicata as evidenced from some reliable physiobiochemical...
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Posted by admin on Nov 30, 2018 in |
Aspergillus produces both airborne and waterborne infections with deadly consequences depending on the species involved and the immune status of patients. Patients may remain asymptomatic for up to 18 months. The severity of aspergillosis is mainly seen in HSCT recipients with mortality up to 90%. Though aspergillosis is primarily opportunistic and lung is the primary site of infection yet deviation observed where the primary site was organs other than lungs. The major reasons behind invasion are prolonged (>3 weeks) high dose corticosteroid therapy, broad-spectrum antibiotics, CMV infection, iron overload, decreased neutrophil count (<500 cells/mm3), etc. Monoclonal technology in the form of EB-A2 and JF5 antibody can identify fungal antigen much before the appearance of clinical symptoms. Selection of a test and its success to determine fungal invasion depend on associated morbidity as galactomannan assay is more suitable in HSCT recipients rather than solid organ transplant recipients whereas PCR is specific for cancer patients with thrombocytopenia to differentiate between aspergillosis and histoplasmosis. Thorough knowledge about the neutrophil profile is required...
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Posted by admin on Nov 30, 2018 in |
Hepatocellular carcinoma (HCC) is a major cause of cancer death. Hepatocellular carcinoma (HCC) is the most common type of primary liver cancer. It is the fifth most common cancer worldwide and the third most common cause of cancer mortality. Despite advances in prevention techniques and new technologies in both diagnosis and treatment incidence and mortality continue to rise. It is less common in most parts of the developed Western world but appears to be increasing substantially in incidence. This malignancy occurs more often among men and older person. Rates of HCC are particularly high in Eastern / Southeastern Asia and Africa, intermediate in Southern Europe and low in most high-income countries. The most prominent risk factors for this cancer are hepatitis B virus (HBV) and hepatitis C virus (HCV). Some other factors are participating in a high incidence of HCC such as cirrhosis, cigarette smoking, alcohol drinking, obesity, aflatoxin exposure, familial/genetic factors, and metabolic disorders. The present review has aimed an overview of worldwide incidence, determinants or risk factors...
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Posted by admin on Nov 30, 2018 in |
The objective of this study was to formulate and characterize Tacrine loaded poly (lactide-co-glycolide) (PLGA) nanoparticles used for the treatment of alzheimer’s disease and were prepared by modified nano precipitation method. Pharmacodynamics studies of the nanoparticles were evaluated for brain targeting and memory improvement in scopolamine-induced amnesic mice using Morris water maze test and inhibitory step down avoidance. The nanoparticles were characterized for drug content, particle size and particle morphology using TEM. In-vitro studies were determined by diffusion cells. The particle size of the prepared nanoparticles ranged from 247 nm to 293 nm. Nanoparticles of Tacrine were obtained with entrapment efficiency of 72.34-81.32%. The drug release from the Tacrine nanoparticles was sustained in batch TPGN-3for 24 h with 85.67% drug release. The in-vitro cytotoxicity studies indicate that the IC50 of the Tacrine loaded nanoformulations shown improved in the reduction of the IC50 but plain nanoparticles did not show severe cytotoxicity. In cellular uptake study of the optimized formulation TPGN-3, shows significant intracellular accumulation when compared with pure drug and...
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