Posted by admin on Jun 1, 2011 in |
The methanol extract of the stem bark of Anogeissus leiocarpus was evaluated in vivo at 2.5mg/kg for antioxidant, hepatoprotective and ameliorative effect on hepatocellular injury following pre-treatment or post-treatment with carbon tetrachloride (CCl4). Levels of the lipid peroxidation product, malondialdehyde (MDA) or thiobarbituric reactive substances (TBARS) were taken as a measure of oxidative stress, while levels of biochemical such as aspartate aminotransferase, alanine aminotransferase and bilirubin (total and conjugated) were taken as biomarkers of liver damage. Irrespective of whether the animals were pre- or post- treated with Anogeissus leiocarpus, there was no statistical difference between the levels of MDA and markers of liver damage in the groups on A. Leiocarpus + CCL4 group and Vitamin E + CCl4, although both were significantly (P<0.05) lower than in the group on CCL4 only. However, malondialdehyde (MDA) levels in the heart, and to some extent, in the kidney, were hardly influenced by the treatments. These results indicate that methanolic extract of the stem bark of Anogeissus leiocarpus possess antioxidant, hepatoprotective and ameliorative...
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Posted by admin on Jun 1, 2011 in |
The present work carried out the study to investigate the antihyperglycemic, oral glucose tolerance test (OGTT) and glycogenesis effects of the different fractions (Petroleum ether, ethyl acetate and chloroform) of ethanolic extract of Brassica oleracea. The different fractions of the extract were administered intraperitoneally as a single dose of 150 mg/kg body weight to alloxan induced as well as glucose induced diabetic rats and found to reduce blood glucose level significantly (p<0.05). The different fractions of Brassica oleracea to the alloxan-induced diabetic rats resulted in the significant elevation of liver glycogen content which was decreased by 49% in diabetic control. The plant fractions also improve the glucose tolerance in the glucose induced rats. The effects of plant fractions were compared with standard drug metformin. The phytochemical screening tests indicated that the different constituents such as saponins, tannins, triterpenes, alkaloids and flavonoids etc. were present in the plant which has antidiabetic and glycogenesis properties. Thus, this investigation paves the way for plant based diabetic treatment and indicates that various fractions...
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Posted by admin on Jun 1, 2011 in |
Premna integrifolia Linn. (Family: Verbenaceae) is a medicinal plant which is traditionally used against a number of diseases including inflammatory condition. On the scientific basis of traditional uses, the ethanolic extract of leaves of Premna integrifolia Linn. was assessed for its possible analgesic and antimicrobial activity. The analgesic activity of the sample was studied using acetic acid induced writhing model in mice. Antibacterial activity of leaves of Premna integrifolia Linn. was tested by using the disc diffusion method. In analgesic activity, the extract produced 52.17% (p<0.01) acetic acid induced writhing inhibition in mice at the dose of 500 mg/kg body weight, which is comparable to diclofenac sodium 65.21% (p<0.01) at the dose of 25 mg/kg body weight. The extract showed significant antibacterial activity against both gram positive and gram negative bacteria. All the results tend to justify the traditional uses of the plant and require further investigation to identify the chemicals responsible for these...
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Posted by admin on Jun 1, 2011 in |
Nanocapsule consists of a thin membrane surrounding a core (Liquid, solid) with their size ranging from 10nm to 1000 nm. Nanocapsules are submicroscopic colloidal drug carrier systems composed of an oily or an aqueous core surrounded by a thin polymer membrane. The membrane may be composed of natural or synthetic polymers. Two technologies can be used to obtain such Nanocapsules: the interfacial polymerization of a monomer or the interfacial nano deposition of a preformed polymer. The nanometric size of Nanocapsule can be interesting for many applications like cosmetics, perfumes or pharmaceutical industries. This article is an extended review of these Nanocapsule technologies and their applications for the treatment of various diseases. The Nanocapsule is used in various fields for drug delivery in case of tumors, as a Nanocapsule Bandages to Fight Infection, as a liposomal Nanocapsule in Food Science and Agriculture, in delivering radio therapy and as a self healing...
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Posted by admin on Jun 1, 2011 in |
Asavarishta is a very popular dosage form in ayurvedic medicines. It is a unique liquid dosage form that contains self generated alcohol, often referred as medicated wine. This self generated alcohol is produced by method of fermentation. Asavarishtas are manufactured by industries in batch size of thousand liters. Larger batch sizes of process specific products for high technology are the need of the time. The large scale industrial fermentation must produce high yields of product at least possible expenses and the recovery of product must be more. Thus the research is required to adapt the fermentation to existing types of fermentation equipment and to increase the yield of product. As self generated alcohol content should not exceed 11% v/v the fermentation process should be at a controlled rate and should be monitored precisely. Many times contamination by microorganisms during process of fermentation takes place if proper care is not taken during fermentation which is hazardous to product. Incubation time required for fermentation depends on temperature of environment. The temperature...
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