Posted by admin on Jun 1, 2012 in |
A simple, rapid, sensitive and cost effective difference spectrophotometric method have been developed for the determination of Febuxostat in its tablet dosage form. The method is based on the induced spectral changes upon changing the pH of the medium that differ in their UV spectra. Difference spectrum, obtained by keeping Febuxostat in 0.1N NaOH in reference cell and same in 0.1N HCl in sample cell, showed two characteristic peaks at 260nm and 315nm with positive and negative absorbance respectively and viceversa. Difference of absorbance between these two maxima was calculated to find out the amplitude, which was plotted against concentration. The calibration curve is linear over the concentration range of 5-25 µg/ml (r2 = 0.999), with a detection limit of 0.58µg/ml. The method was successfully applied to the commercial pharmaceutical drug without interference from common ingredient accompanying the drug along with its dissolution profile and very cost effective as its prevents the use of hazardous and costly organic...
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Posted by admin on Jun 1, 2012 in |
Polypodium vulgare Linn. also called as Bisfaij in Unani system of medicine is a perineal fern growing to a height of 30cm. Polypodium vulgare Linn. rhizome is used in European, American, Chinese, and Unani and Ayurveda traditions. It is claimed to be efficacious in jaundice, dropsy, scurvy and combined with mallows it removes hardness of the spleen. The distilled water of the roots and leaves is considered good for ague (malarial fever), and the fresh or dried roots, mixed with honey and applied to the nose, were used in the treatment of polypus The fresh root is used in the form of decoction, or powder for melancholia and also for rheumatic swelling of the joints. The rhizome extract was found to possess anti-epileptic activity. The ecdysones present in the rhizome (0.07%-1% dry weight)was seen to act topically on a wide variety of arthropods and caused abnormal molting and death, so ecdysone analogues may be useful not only as insecticides but also miticides. The aqueous extract of Polypodium vulgare Linn....
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Posted by admin on Jun 1, 2012 in |
A new series of flurobenzothiazole incorporated 1, 3, 4 – thiadiazole compounds have been synthesized. The structure of the synthesized compounds was confirmed by UV, IR, 1H NMR, Mass spectral analysis and evaluated for their antimicrobial activity against Proteus vulgaris NCTC 4635, Micrococcus leutus NL98, Aspergillus flavus ATCC 46646by disc diffusion method. The compounds SH8 and SH11 were also evaluated for the anti-inflammatory activity by carrageenan-induced paw oedema method. The synthesized compounds (SH6 to SH11) showed good antimicrobial activity. However the antimicrobial activity of the synthesized compounds against the tested organisms was found to be less than that of respective standard drugs used at tested dose level. The anti-inflammatory activity confirmed that the test compound SH11 showed superior activity in the inhibition of oedema than SH8. However, both the test compounds were found to be less active than the standard drug...
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Posted by admin on Jun 1, 2012 in |
A new, simple, sensitive and reproducible spectrophotometric method has been developed for the estimation of Flucloxacillin in pure form. Method involves the determination of Flucloxacillin by dissolving in water and followed by measuring the absorbance at 273 nm. The linearity was obtained in the concentration range of 100-300 µg /ml. The suitability of method for quantitative analysis of Flucloxacillin was proved by validation. This method was extended to tablet formulation and there was no interference from excipients and diluents. This method has been statistically validated and is found to be precise and...
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Posted by admin on Jun 1, 2012 in |
The synthesis of gold nanoparticles has received considerable attention and has been a focus of research due to their high chemical and thermal stability, fascinating optical, electronic properties, and promising applications such as nanoelectronics, biomedicine, sensing, and catalysis. Different physical and chemical methods for gold nanoparticles synthesis are known but these methods are either expensive or are not eco-friendly due to use of hazardous chemicals, stringent protocol used during the process. These drawbacks necessitate the development of nonhazardous and greener methods for gold nanoparticles synthesis. Therefore, there has been tremendous excitement in the study of gold nanoparticles synthesis by using natural biological system. Microorganisms thus play a very important role in the eco-friendly and green synthesis of metal nanoparticles. The inherent, clean, nontoxic and environment friendly ability of eukaryotic and prokaryotic microorganisms, plants system to form the metal nanoparticles is particularly important in the development of nanobiotechnology. This review contains a brief outlook of the biosynthesis of gold nanoparticles using various biological resources, characterization and their potential application in...
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