Posted by admin on Jun 1, 2011 in |
Cyclocondensation of α-bromo ketones with thiourea afforded 4-substituted 1, 3-thiazole-2-amines. These compounds on further treatment with α-bromo ketones afforded 3, 6-disubstituted imidazo[2, 1-b][1, 3]thiazole (1a-1j). All the synthesized compounds were confirmed for their structure by FTIR, 1H NMR and GSMS spectra and tested in vitro for their anti-microbial activity by cup plate method against Gram-positive bacterial strains (Bacillus subtillis, Staphylococcus aureus) Gram-negative bacterial strains (Pseudomonas aerugenosa, Kleibsella pneumonia) and fungal strains (Aspergillus niger, Candida albicans). The analogues 1b, 1h and 1i showed promising antimicrobial activity against gram-negative Kleibsella pneumonia; where as analogues 1b, 1e, 1g and 1h showed promising antifungal activity against Candida...
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Posted by admin on Jun 1, 2011 in |
In Traditional Ayurvedic system of treatment Tragia involucrata Linn. is intended to use for diabetic patients has been screened for antioxidant activity. For antioxidant studies, aqueous ethanolic extract of Tragia involucrata (AEETI) was administered orally for 28 days at a dose of 250 and 500 mg/kg body weight to Streptozotocin- Nicotinamide induced Wistar rats. All the animals were sacrificed on the 29th day and the levels of LPO, SOD, CAT, GPx and GSH in kidney and liver of control and experimental rats were studied. The AEETI exhibited significant antioxidant activity showing increased levels of superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), reduced glutathione (GSH) and decreased level of lipid peroxidation. These results showed that treatment with AEETI lowers Streptozotocin induced LPO and alters SOD, CAT, GPx and GSH enzymes to reduce oxidative...
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Posted by admin on Jun 1, 2011 in |
Digera muricata (L.) Mart (Amaranthaceae) commonly known as Cancali soppu widely used in traditional system of medicine for the treatment of diabetes mellitus In the present study, Methanol extract of Digera muricata(MEDM) leaves were subjected to phytochemical investigation and evaluated for antidiabetic activity in alloxan induced diabetic rats. MEDM (100, 200 mg/kg) and Glibenclamide (3mg/kg) were administered orally in alloxan (140 mg/kg, i.p.) induced diabetic rats. In acute oral toxicity (OECD Guide line 423) study, administration of MEDM no mortality upto 2000 mg/kg was observed. OGTT, Fasting blood glucose level, body weight, lipid profiles, HbA1c, plasma insulin, and ALP were evaluated in normal and diabetic rats. preliminary phytochemical investigation revealed the presence of alkaloids, flavonoids, glycosides, tannins as the major constituents in the methanol extract .These results suggest that MEDM (200mg/kg) showed antihyperglycemic activity in alloxan induced diabetic...
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Posted by admin on Jun 1, 2011 in |
Aim of the present study was to isolate and characterize the biochemical principle and investigate the hypoglycemic activity of bark of Alangium salviifolium Wang in Alloxan induced hyperglycemic rats. The bark of Alangium salviifolium barks were collected and dried in shade and subjected to extraction with petroleum ether, Chloroform and methanol. Each extracts were subjected to preliminary phytochemical analysis. Petroleum ether and Chloroform extract were subjected to chromatography. Two compounds were isolated and purified by alcohol then, subjected to physical and spectral studies. Spectral results revealed that isolated compounds may be phytosteroids. Hypoglycemic activity was performed by alloxan induced method. MEAS were administered orally to the hyperglycemic induced rats at the dose of 250mg/kg, 500mg/kg and 750mg/kg. Glibenclamide was used as reference drug. Then blood glucose levels were measured at the time interval of 30 mins, 1, 2, 3, 4 hrs and 8hrs by one touch glucometer. Then blood samples were collected from all rats and evaluated for biochemical parameter. Significant reductions in the blood glucose levels were observed....
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Posted by admin on Jun 1, 2011 in |
Recently, heterocyclic compounds analogues and their derivatives have attracted strong interest in medicinal chemistry due to their biological and pharmacological properties. The small and simple benzothiazole nucleus possesses numerous biological properties like – antitumor, antimicrobial, anti-inflammatory, anticonvulsant, and antidiabetic activities. These activities are also possessed by its substituted derivatives as well. The present review focuses on some commonly used easy procedures to synthesize the benzothiazole moiety and its derivatives, which comprise of different biological...
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