Posted by admin on Jun 1, 2011 in |
For many decades treatment of an acute disease or a chronic illness has been mostly accomplished by delivery of drugs to patients using various pharmaceutical dosage forms including tablets, capsules, pills, suppositories, creams, ointment, liquids, aerosols and injectables as drug delivery systems are the primary pharmaceutical products commonly seen in the market. In the past two and a half decades several advancements has been made in the pharmaceutical products. They have resulted in the development of new techniques for drug delivery1. These techniques are capable of controlling the rate of drug delivery, sustaining the duration of therapeutic activity and targeting the delivery of drug. A series of three different trial formulation of Rabeprazole Sodium, Microsphere using Chitosan an aminopolysaccharide, so as to optimize the sustained conditions. In the case of microsphere, the initial formulation was done with 0.5% Chitosan solution and drug. Then the concentration of chitosan had been increased to 1.5%. It showed that the percentage release was maximum 65.2% for the chitosan microsphere in the formulation F3,...
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Posted by admin on Jun 1, 2011 in |
Buccal drug delivery has gained significant attention and momentum since it offers remarkable advantages. Over past few decades, buccal route for systemic drug delivery using mucoadhesive polymers to significantly improve the performance of many drugs has been of profound interest. This review article is an overview of buccal drug delivery systems encompassing a review of oral mucosa, formulation considerations for buccal drug delivery system, theories and mechanism of mucoadhesion, different mucoadhesive formulations for buccal drug delivery and active ingredients delivered via the buccal route. Additionally, commercial technologies and future prospects of this route of drug delivery are discussed....
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Posted by admin on Jun 1, 2010 in |
Cordyceps militaris is an important medicinal mushroom useful for the extraction of several bio-metabolites for natural drugs to revitalize the various physiological systems of the body from the ancient era. The constituents of C. militaris are now using widely in the modern pharmaceutical industries. The active principles of C. militaris are beneficial to act principally as pro-sexual, anti-cancer, immunomodulatory, and anti-oxidant agent, let alone its others beneficial activities for most of the systems of the body. In addition, it has lots of clinical applications. The prospects of this novel mushroom could be used not only for modern medicinal manufacturers, but also for the community people for the betterment of their health. The present review highlights the importance of this medicinal mushroom C. militaris, also aiming to draw necessary attention of the researchers as a frontier...
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Posted by admin on Jun 1, 2010 in |
Barberries are a large group of evergreen shrubs, found in Lalitpur, Allahabad, Bhopal and Haldwani etc. It is an evergreen shrub. Commonly, its fruits are called as berries. This plant is generally use in case of diabetes and mouth ulcer, as a traditional use. Type 2 diabetes mellitus (formerly called NIDDM, type II or adult-onset) is characterized by insulin resistance in peripheral tissue and an insulin secretory defect of the β- cell. This is the most common form of diabetes mellitus and is highly associated with a family history of...
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Posted by admin on Jun 1, 2010 in |
Psoralia corylifolia commonly known as Babchi, Bavachi in Hindi, is a well known herb in Indian system of medicine to treat various disorders including diabetes mellitus without any scientific evidences. Therefore this study was designed to investigate in vivo hypoglycemic and antidiabetic potential of methanolic extract of seeds of Psoralia corylifolia in glucose loaded animals and alloxan induced diabetic animals. In both the models Psoralia corylifolia reduced the blood glucose level when compared to diabetic control group and exert a significant hypoglycemic and antidiabetic activity. However the potency of the herb was less than that of standard drug metformin. Psoralia corylifolia methanolic extract also reversed the body weight in normal and alloxan induced diabetic animals. The results of this study revealed the presence of a significant antidiabetic potential of methanolic extract of Psoralia corylifolia in alloxan induced diabetic rats. On the basis of this further research work is needed to investigate exact mechanism of action and also to isolate the active constituent/s responsible for the...
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