Posted by admin on May 31, 2024 in |
The objective was to determine the effect of calcium phosphate composite with doxycycline molecularly included as a graft on bone defect after tooth extraction for slow delivery of drug. Methods: animal were distributed in to four groups: Group 1 (Blood Clot), Group 2 (TCP), Group 3 (TCP/PCL/PLGA), and Group 4 (TCP/PCL/ PLGA/ DOX/CD). An alveolar bone defect was created, and the analysis was conducted at preset intervals of T1 (14 days) and T2 (28 days). Results: The results of the histological study using H&E staining demonstrated the existence of newly created bone in all experimental groups. Group 4 exhibited the biggest area of newly formed bone at T1, and this observation was consistent across all time points examined. Group 4 exhibited a consistent volume across the measured time intervals, as evidenced by the existence of more advanced and structured trabeculated bone in T2 in comparison to T1. Even more Group 4, notably T2, displayed the highest proportion (47%) of newly formed bone area in comparison to Group 1 (36%),...
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Posted by admin on May 31, 2024 in |
The term nutrabeverage was applied to the product of alcoholic fermentation made by using Kefir grains. In the present studies initially, the pH of the pomegranate juice sample was 3.7, 3.5 for strawberry and 3.8 pH for pineapple. The titrable acidity optimum was found in pineapple at 3.37 % while 16% TSS was found in pomegranate. The highest TSS content before fermentation was observed at 160brix, 90brix and 14.30 brix in the pomegranate, strawberry and pineapple juice respectively. After 15 days of fermentation at 25°C with pH 4.5, the lowest TSS content of 120brix, 8.30brix, and 100brix in the pomegranate, strawberry and pineapple nutrabeverage was observed respectively. The titrable acidity was found to increase after 15 days of fermentation at 25°C in all nutrabeverage while reducing sugar was found to the maximum before fermentation. The lowest reducing sugar content was 9.73%, 6.81% and 8.82% in the pomegranate, strawberry and pineapple nutrabeverage respectively recorded after fermentation. The maximum alcohol content 6.9%, 4.3% and 5.2% in the pomegranate, strawberry and pineapple...
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Posted by admin on May 31, 2024 in |
Phytosterols, a subclass of steroids, have gained considerable attention in scientific research and nutrition due to their potential health benefits. This article presents an overview of phytosterols, encompassing their sources, chemistry, extraction methods, analytical techniques, and biological activities. Phytosterols, structurally resembling cholesterol, are found abundantly in plants, animals, and fungi. Their physiological roles include influencing membrane fluidity and acting as second messengers in signal transduction pathways. Incorporating phytosterol-rich foods into the diet has been linked to various health benefits, particularly in reducing cholesterol levels, as recognized by regulatory bodies like the European Food Safety Authority and the FDA. The article discusses various extraction methods for phytosterols, emphasizing the need for environmentally friendly approaches to minimize the use of organic solvents. Traditional techniques such as Soxhlet extraction are effective but pose health and environmental concerns, driving the exploration of alternative extraction technologies. Phytosterol chemistry, characterized by specific carbon atoms and side chains, is explored, highlighting their steroid structure and different forms in nature. Analytical methods such as gas chromatography (GC),...
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Posted by admin on May 31, 2024 in |
The contemporary generation utilizes specific pharmaceuticals to treat ailments, irrespective of their detrimental effects on genetic material. More specifically, the lifestyles of expectant mothers and the medications they come across during pregnancy, such as antiemetic, antacid, antihistamine, analgesic, antibacterial, diuretic, sedative, and other medications, exert a significant influence on the utilization of these drugs. Certain pharmaceuticals require a period of 30 to 60 minutes to reach equilibrium in maternal and fetal circulation, albeit at different concentrations and under varying conditions. Variables, including placental potency, dosage, maternal characteristics, drug efficacy, and gestational age at the time of exposure, contribute to the impact of drugs on the fetus. Notably, during the initial three weeks of pregnancy, a developing fetus is more susceptible than the mother. The National Institutes of Health (NIH) has documented spontaneous abortion, allergies, preeclampsia, gestational diabetes, hypertension, depression, and anxiety, as well as mild to severe functional or metabolic abnormalities as commonly reported complications during pregnancy. This review aims to ascertain the transplacental genotoxicity associated with medications employed...
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Posted by admin on May 31, 2024 in |
The antidiabetic and antioxidant efficacy of traditional medicinal plants from North-Eastern India remains largely unexplored. This study seeks to address this gap by examining the properties of 11 such plants. The plant samples were subjected to extraction using four different solvents. Their antidiabetic potential was evaluated through in-vitro α-glucosidase and α-amylase inhibition bioassays, while the antioxidant activity was assessed using the DPPH Scavenging assay. The results were compared to the standard antidiabetic drug, acarbose. Out of the 11 plants, five species demonstrated significant antidiabetic properties, inhibiting more than 50% of α-glucosidase and α-amylase enzyme activities. The petroleum ether tuber extract of Stephania glandulifera exhibited the highest α-glucosidase inhibition (99%), followed by the methanol leaf extract of Begonia roxburghii (94%) and the water leaf extract of Antidesma acidum (85%). In the α-amylase inhibition assay, Equisetum debile methanol extracts showed a 64% inhibition, followed by the leaf extract of A. acidum with a 62% inhibition in the methanol leaf extracts. Comparatively, methanol and water leaf extracts of Debregeasia longifolia displayed 64%...
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