Posted by admin on May 31, 2021 in |
Cancer is one of the most dreaded diseases across the globe. Drug resistance and adverse effects of various classical chemotherapeutic agents are the major challenges for cancer therapy. Cancer treatments with synthetic drugs are associated with severe side effects. Synthetic drugs address symptoms caused by diseases; on the other hand a plant-based medicine usually directs towards aiding body’s own healing process as it is in sync with nature. Natural products and their derivatives can be a promising alternative to existing cancer therapy. Several phytoconstituents have been identified as a valuable source of clinically important anticancer agents. Novel chemical entities and compounds of natural origin have been explored for efficient anticancer activity. Altholactone, a styryl lactone primarily found in Goniothalamus sp., exhibits cytotoxic and antitumor activities. Therefore, an attempt has been made to summarize altholactone analogues. Its structure-activity relationship (SAR) is suggested as a potent anticancer drug candidate, which may provide a structural framework to design and develop a novel anticancer drug in the...
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Posted by admin on May 31, 2021 in |
The present work aims to formulation and characterization of a topical liposomal gel for ciprofloxacin hydrochloride. The drug lipid interaction studies were carried out by FTIR analysis, X-ray diffraction study, and DSC study, and no changes of physicochemical properties of ciprofloxacin were found. The thin-film hydration method was used for the preparation of liposomes consisting of phosphatidylcholine (PC) and cholesterol (CH). For hydrogel preparation, Carbopol 940 was used. The maximum entrapment efficiency of 79.51 ± 2.395 was found from liposomes formulated with PC/CH at a weight ratio of 30:10 (batch number – F5), and by increasing cholesterol content above this limit, the encapsulation efficiency decreased. All the prepared formulations were found stable and the liposomal gel approach of ciprofloxacin hydrochloride showed better skin residential time than the marketed formulation. The in-vitro drug permeation was found to be around within the range of 0.194-0.319 over a period of 12 h for different batches. In conclusion, ciprofloxacin hydrochloride liposomal hydrogel is a smart and suitable drug delivery system for improving the...
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Posted by admin on May 31, 2021 in |
Breast cancer is the most common type of cancer found in women. Although considerable advances have been achieved in the diagnosis and treatment of breast cancer, medical research routinely thrives towards the development of newer technologies for the treatment of breast cancer. The current study aimed at the development of nanomedicine, in the form of silver nanoparticles from the aqueous extract of algae Spirulina platensis, for the treatment of breast cancer. The synthesis of silver nanoparticles was exhibited by UV-visible spectroscopy, and the nanoparticles were characterized by NTA, FTIR and TEM. The anti-tumor potential of this nanoparticle formulation was evaluated on MCF7 breast cancer cell line and its cytotoxicity was compared with crude aqueous algal extract as well as the recommended breast cancer chemotherapy drugs. The results obtained were promising. NTA analysis indicated a mean particle size of 72 nm. FTIR spectrum showed the presence of alcohol, phenols, carboxyl, and aromatic groups in the nanoparticle formulation, which were responsible for the biological activity. The anti-cancer activity studies revealed that...
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Posted by admin on May 31, 2021 in |
Oxidative stress is a condition that might predispose individuals to diseases, including cancer. The 8- hydroxydeoxyguanosine (8-OHdG) is an index that reflects DNA damage caused by oxidative stress in the body. In this study, Commiphora molmol (Myrrh) (C. molmol) (Myrrh) that belongs to the family Burseraceae were investigated for its potential favorable properties to blunt DNA damage induced by oxidative stress employing 8-OHdG assay using human lymphocyte cultures. Lymphocytes were separated from blood samples collected from healthy volunteers, cultures, and incubated in aqueous extract of C. molmol (Myrrh) at 0, 10, 100, and 1000 µg/ml. Extracts at 10,100 and 1000µg/mL from the oleo-gum resin of C. molmol (Myrrh) significantly decreased levels of 8-OHdG. The oleo-gum resin of C. molmol (Myrrh) medicinal plants can be used as useful agents to counteract oxidative DNA damage in cultured cells. Collectively, the data revealed that oleo-gum resin of C. molmol (Myrrh) possesses favorable antioxidants and therefore lends support to its therapeutic...
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Posted by admin on May 31, 2021 in |
A short selective, precise, accurate, and sensitive method for the estimation of Tolcapone and Quinapril was done by RP-HPLC. The assay of Tolcapone and Quinapril was performed with tablets, and the % assay was found to be 100.19 and 100.45, which shows that the method is useful for routine analysis. The linearity of Tolcapone and Quinapril was found to be linear with a correlation coefficient of 0.999 and 0.999, which shows that the method is capable of producing good sensitivity. The acceptance criteria of precision percent RSD should be not more than 2.0%, and the method show precision 0.2 and 0.7 for Tolcapone and Quinapril, which shows that the method is precise. The acceptance criteria of intermediate precision are RSD should be not more than 2.0%, and the method show precision 0.3 and 0.7 for Tolcapone and Quinapril, which shows that the method is repeatable when performed in different days also. The LOD and LOQ for Tolcapone were found to be 3.07 and 9.98, and LOD and LOQ for...
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