Posted by admin on May 31, 2022 in |
Hedychium spicatum is one of the plant species reported from the northern Himalayan ranges of India, belonging to the family Zingiberaceae, with ethnobotanical values and is well-known for their ethnomedicinal applications. In the present investigation, pet ether and ethanolic rhizome extracts of Hedychium spicatum were Analyzed by gas chromatography-mass spectrometry (GC–MS) to identify the important phytochemical constituents. The GC–MS analysis of pet ether and ethanolic extracts from rhizomes of Hedychium spicatum detected the presence of numerous phytochemical compounds. Further, the literature review reported rhizome extracts of H. spicatum to have remarkable anti-inflammatory, antioxidant, cardioprotective, and antibacterial activities. The results of DPPH and ferric reducing antioxidant power assay recorded maximum antioxidant activity in Hedychium spicatum ethanolic rhizome extract at 500mg/kg dosage. As well as the ethanolic extract exhibited maximum α-amylase inhibition activity followed by exhibiting aldose reductase inhibition. Subsequently, the six identified compounds were analyzed for their bioactivity through in-silico molecular docking studies. Results revealed that 7-hydroxyhedychenone might have maximum antioxidant and antidiabetic properties among the phytochemical compounds identified, followed...
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Posted by admin on May 31, 2022 in |
The various medicinal plants have been used in the Ayurvedic medicine system to treat various diseases for a long period. The plant shows first-line defense mechanisms by secondary metabolites against different diseases and foreign particles to build immunity. This metabolite are classified as phyto & polyphenolic compound. Antioxidants play an important role in humans due to the presence of this polyphenolic compound and other phyto-compound. Either body metabolism generates free radical as an endogenous source or different pollution, food intake as an exogenous source. Cellular damage is happened by the excessive production of free radicals. Antioxidants arrest the free radicals by reducing their activity. There are nine medicinal plants such as Leucas cephalotes Spreng (Dronapushpi), Andrographis paniculata Nees (Kalmegh), Piper longum (Pippali), Desmodium gangeticum DC (Shalmali), Plumbago indica Linn (Raktachitrak), Zingiber officinale Rosc (Adrak), Calotropis procera R.Br. (Arka), Sesbania sesban Merrill (Jayanti), Hemidesmus indicus R. Br (sariva)] selected on the basis of their Ayurvedic property. Phytochemical analysis, Total phenolic content (TPC), total flavonoid Content (TFC) and antioxidant tests via...
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Posted by admin on May 31, 2022 in |
Parkinson’s disease (PD), identified as the second most common neurodegenerative disorder, is a progressive disease that impairs the ability to control voluntary movements mainly. According to the findings of the pathogenesis of PD, lesions in dopaminergic innervation of the basal ganglia cause degeneration of neurons in the substantia nigra and thus leads to loss of striatal dopamine level. Hence, enhancement of dopaminergic transmission restores partial motor functions. In the current review, the possible in-vivo animal models have been described in detail, which mostly resembles the Parkinsonian state in humans and has helped research involving pathogenesis, treatment, and evaluating drugs having Anti-Parkinson activity. This study aims to set down all the possible models to screen agents that have a therapeutic or symptomatic role in treating Parkinson’s disease. Every model has its advantage and disadvantage, which must be carefully considered when choosing the model to be...
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Posted by admin on May 31, 2022 in |
In any nation’s public health care system, plants play an essential role in therapeutic treatment. The plant Thevetia peruviana is an evergreen ornamental dicotyledonous shrub belonging to the family Apocynaceae. Thevetia peruviana is widely distributed in Central and South America and Asian countries, especially in India and Srilanka. Alkaloids, flavonoids, steroids, terpenoids, tannins, saponins, cardiac glycosides, and other secondary metabolites are found in Thevetia peruviana. All parts of these plants are toxic and contain a variety of cardiac glycosides, including neriifolin, thevetin A, thevetin B, and oleandrin. The leaves of the plant are used as a cardiotonic and diuretic and are also reported to possess medicinal value in traditional systems of medicine. Several studies reported pharmacological activity in various plant parts, including seeds, flowers, bark, fruits and leaves. The purpose of this review is to provide the complete data, including morphology, cultivation and propagation, distribution, phytochemistry, traditional uses & pharmacological...
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Posted by admin on May 31, 2022 in |
Drug-Related Problem (DRP) affects the hospital stay, healthcare budget, quality of life, morbidity, and mortality. The study aims to assess the prevalence and predictors of DRPs in hospitalized patients and provide intervention. A prospective interventional study was conducted in the in-patient medical department of the NGO hospital. A total of 310 subjects were enrolled and screened for the presence of DRP. The identified DRPs were categorized according to the Hepler and Strands. Depending on DRP, the clinical pharmacist provided an intervention at the patient and physician level and recorded the acceptance. The data was analyzed using SPSS™. Binary logistic regression was employed to associate risk factors with DRPs. The prevalence of DRPs in the medical department was 80.0%, with a 0.93 DRP/patient average. Drug interactions(DI) (28.4%) and adverse drug reactions (ADR) (21.8%) are the most common DRPs. Anti-microbials (78.0%) and Anticonvulsants (81.2%)showed a greater risk of developing DRPs. Variables like advanced age, the habit of alcohol and smoking, hospital stay, and polypharmacy were significantly associated with DRPs. A total...
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