Posted by admin on May 31, 2022 in |
Hypothyroidism is a progressive disorder characterized by varying degrees of thyroid failure, metabolic consequences, and hemodynamic changes that decrease renal plasma flow and glomerular filtration rate, increasing serum creatinine level. Therefore, the present study aimed to evaluate and analyse the level of serum urea, creatinine and thyroid function tests in cases of subclinical hypothyroidism and apparently healthy controls and determine whether thyroid dysfunction has detrimental effects on serum creatinine and urea levels in subclinical hypothyroidism cases. Both thyroid function tests (TSH, T3, and T4), serum urea, and creatinine were analyzed in 45 cases with subclinical hypothyroidism and 45 healthy subjects. Patients with subclinical hypothyroidism had a statistically significant rise in creatinine levels compared to controls. In contrast, there was no significant difference in serum urea levels between patients and controls. There was likewise a positive correlation between creatinine and urea in patients with subclinical hypothyroidism. The study results indicate that renal function should be regularly monitored in patients with subclinical...
Read More
Posted by admin on May 31, 2022 in |
Punica granatum (Pomegranate) external peel extract in 70% ethanol was challenged against two non-albicans Candida spp. to find out it’s possible antifungal effects in disc diffusion technique as well as in microtiter dilution to find out MIC levels. Although both showed sensitivity zones in disc diffusion technique at 100 mg/mL concentration of the extract, at lower concentrations (<16.6 mg/mL), only C. guilliermondii showed MIC value at 0.52 mg/mL, while C. tropicalis did not show any inhibition of growth at these concentrations of the...
Read More
Posted by admin on May 31, 2022 in |
The present study aims to develop a verse phase HPLC method for the simultaneous estimation of Metformin and Saxagliptin. In bulk and pharmaceutical dosage form and to validate the proposed method in accordance with ICH guidelines for the intended analytical application. Multiple trials were run to Metformin and Saxagliptin, get eluted with good peak symmetric properties. Mobile phase Phosphate buffer: Methanol: Acetonitrile (40:5:55), Column Hypersil silica and flow rate 1.0ml, detection wavelength at 233nm, column temperature 300C and diluents Water: Methanol (50:50). Column Hypersil silica and flow rate 1.0 ml, detection wavelength at 210 nm conditions were finalized as an optimized method. This method was validated for Stability Data, System suitability, Precision, Linearity, Accuracy, Robustness, Ruggedness, LOD, and LOQ. System suitability parameters were studied by injecting the standard five times, and results were well under the acceptance criteria. Linearity study was carried out between 25% to 150% levels, r2 value found 0.999. By using the above method, assay of the marketed formulation was carried out 99.63% was present. So,...
Read More
Posted by admin on May 31, 2022 in |
Microsphere drug delivery is a novel drug delivery approach for sustaining and controlling the rate and release of active pharmaceutical ingredients. Microspheres are the choice of drug delivery for delivering the drug at a specific site to release the encapsulated drug to treat various diseases. Microspheres drug delivery is an attractive dosage form in terms of its flexibility and sustaining the release as compared to other sustained and controlled formulations. Most of the antihyperlipidemic drugs come under BCS class-II, which leads to poor solubility but higher permeability, the oral bioavailability of statins categories drug possess less bioavailability due to the poor solubility; hence microspheres are the best candidate for delivering antihyperlipidemic drugs to the systemic circulation and improving the systemic bioavailability of drug for a longer period with lesser adverse effects. Therefore microspheres can be used in various medical departments like oncology, gynecology, radiology, pulmonary, cardiology, diabetes, vaccine therapy, etc. this review article focuses on recent different methods of preparation. The microspheres formulated can be later evaluated and characterized...
Read More
Posted by admin on May 31, 2022 in |
A novel series 3(a–d) 1-(4-benzhydryl piperazin-1-yl)-3-(di substituted) propan-1-one &1-(4-benzhydrylpiperazin-1-yl)-3-(piperidin-1-yl) propan-1-one (3e) & 1-(4-benzhydrylpiperazin-1-yl)-3-morpholinopropan-1-one (3f) compounds have been synthesized and screened for its anticonvulsant and neurotoxic activity, After i.p. injection to rat at doses of 30, 100, and 300 mg/kg body weight. Synthesized compounds were examined in the maximal electroshock-induced seizures (MES). Spectroscopic data were consistent with the structure of newly synthesized compounds. The neurotoxicity was assessed using the rotarod method. In the prepared series, 3f was found to be active in the MES screen at 0.5 h, and 4...
Read More
