Posted by admin on May 31, 2025 in |
Hypertension (HTN), a major global health concern and the primary cause of cardiovascular disease (CVD) death is expected to impact 29% of all adults by 2025. Hypertension (HTN) is a multifactorial condition, arising from the complex interaction of hereditary, environmental, and physiological variables that contribute to elevated systolic and diastolic blood pressure. It is frequently caused by dysregulation of blood pressure control mechanisms, such as over activity of the renin-angiotensin system and increased sympathetic nervous system activity. Traditional hypertension therapies, such as ACE inhibitors and beta-blockers, have drawbacks, including low solubility and absorption. As a result, researchers are increasingly focusing on novel treatment approaches, such as medicinal plants and nanotechnology. Herbal plants such as Ashwagandha, Cat’s Claw, Ginger, Ginseng, Murungai, and Touch-Me-Not belonging to different families are renowned for pharmacological activities and have shown potential medicines antihypertensive properties, which are often attributed to their bioactive constituents. Recent breakthroughs in nanotechnology have permitted the manufacture of nanoparticles derived from these plants, improving their stability, bioavailability, and potency. These plant-mediated nanoparticles...
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Posted by admin on May 31, 2025 in |
Perimenopause is a transitional stage in a woman’s life, typically occurring in her 40s, leading up to menopause. During this time, hormonal changes, particularly a decline in estrogen levels, can have a significant impact on bone health. Calcium citrate is a commonly used calcium supplement that is known to promote bone health. Isoflavones are a type of phytoestrogen found in plants, particularlyin soybeans and soy products. The study aimed to compare the effects of calcium citrate and isoflavones on BMD in perimenopausal women with low BMD. 60 perimenopausal women with low BMD, aged 40-55 years, who were divided into two groups: Group A received Calcium citrate supplementation, while Group B received Calcium citrate+Isoflavones supplementation. BMD was measured at baseline and after 3 months using Dual-Energy X-ray Absorptiometry (DEXA). After 3 months, both groups showed improvements in BMD compared to baseline (p <0.05). The increase in BMD was greater in Group B (Calcium citrate + Isoflavones) compared to Group A (Calcium citrate) (p<0.05) Results revealed that the combination of calcium...
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Posted by admin on May 31, 2025 in |
The quest for natural immunomodulators has led to the exploration of traditional Indian herbs, renowned for their immune-boosting properties. In this study the goal was to create and assess a polyherbal formulation that contained extracts of all herbs. A polyherbal tablet was formulated using a combination of Giloy (Tinospora cordifolia), Amla (Emblica officinalis Gaertn), and Tulsi (Ocimum sanctum) in a specific ratio. Giloy (Tinospora cordifolia) is a plant that contains antioxidants. It also has anti-inflammatory, antimicrobial, and antidiabetic properties. Tulsi (Ocimum sanctum) contains antioxidant, antimicrobial, anti-inflammatory, anti-diabetic, Immunomodulatory, anti-carcenogenic properties. Amla, also known as Indian gooseberry, has many properties, including antioxidant, anti-inflammatory, and hepatoprotective. The tablet’s physicochemical properties, such as hardness, friability, and disintegration time, were evaluated. The formulated tablet exhibited satisfactory physicochemical properties. The polyherbal tablet containing Giloy, Amla, and Tulsi demonstrated potent immunomodulatory activity, validating the traditional use of these herbs in Ayurvedic medicine. This formulation offers a promising natural adjunct to conventional immunotherapies, warranting further clinical investigation. Polyherbal formulations have emerged as a promising strategy to...
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Posted by admin on May 31, 2025 in |
Chromosomal non-disjunction is a pivotal error in cell division where chromosomes fall to separate properly during meiosis or mitosis, resulting in an abnormal number of chromosomes, the condition is known as aneuploidy. This phenomenon has significant consequences for human health, as it underpins several kinds of genetic disease, such as Downsyndrome, Turner syndrome and Klinefelter syndrome. Non-disjunction may occur during mitosis, Meiosis-I or meiosis-II and various factors influence how sister chromatids or homologous chromosomes segregate. Maternal age is a significant risk factor, spicily for neostick non-disjunction triggered by prolonged oocyte stoppage in Prophase-I. Additional causes environmental and genetic and epigenetic alterations in cohesinproteins. Non-disjunction can cause developmental issues, miscarriages, mosaicism and chromosomal instability in cancer. The diagnosis of aneuploidy has increased due to advances in diagnostic procedure such as Karyotyping, Fluorescence in-situ hybridization (FISH) and non-invasive prenatal testing. Preimplantation genetic testing (PGT) and genetic counselling provide at risk families with preventive measures. Despite advancement in understanding the molecular causes and effects treatment options remains limited. Continued study is needed...
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Posted by admin on May 31, 2025 in |
Computer-aided drug design programs use mathematical formulas to predict the property value and structure of stable, unknown, and molecular species. Quantum mechanics, hybrid QM/MM, molecular bonding, molecular modelling, molecular mechanics, and QSAR are some of the techniques used in molecular bonding studies. An average drug discovery cycle, from lead identification to clinical trials, is expected to take about a year. Computer-aided drug design technologies have the potential to reduce drug design and development costs by 50% when integrated into a company’s research and development methodologies. Drug development can be accelerated by using computational methods to interpret and direct trials. Computer-aided drug design (CADD) approaches come in two primary varieties: ligand-based drug design (LBDD) and structure-based drug design (SBDD). The three-dimensional structural data from macromolecular targets, like proteins or RNA, is examined by SBDD techniques to identify crucial sites and interactions that are crucial to their...
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