Posted by admin on Jun 30, 2016 in |
In this review our main focus is on flavonoid groups which are one of the main active constituents found with other active constituents like saponins and polysaccharides, while poisonous groups are nitro-compounds, indolizidine alkaloids and the seleniferous derivatives in Astragalus genus. It is well established fact that flavonoid possess many biological activity such as antiallergic, anti-inflammatory, antitumor, antiviral, antioxidant anticancer including anticarcinogenic and prodifferentiative activities. Many flavonoids, including those which are phytoalexins, provide plants with a defense against viral infections. The estrogenic action of many isoflavones is well known and mixtures of flavonoids are commonly used commercially to reduce capillary fragility. Astragalus root is a very old and well known drug in traditional Chinese medicine and have been used to improve resistance to infections and to aid in immunological disorders and viral infections, and also used as hepatoprotective, heart tonic, nephritis and diabetes. This review reports all flavonoids isolated till date which is nearly about 131 from 60 species of Astragalus genus; these flavonoid are further characterized and classified...
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Posted by admin on Jun 30, 2016 in |
Background: In present study, we aim to assess the anticandidal activity of crude extracts and screening of bioactive compounds and their identification by NMR, IR and GC-MS. Results: A total of 192 isolates were isolated from patients having oral and vaginal candidiasis and a total of 134 isolates showed positive results with Gram staining. The selected isolates APKU-2, APKU-3 and APKU-4 were identified as C.albicans, C.lusitaniae and C.krusei by studying its morphological, biochemical, and molecular characteristics. Chemical characterization of the extracted compounds was done by H1NMR, Fourier transform infrared spectroscopy (FTIR), Gas chromatography–mass spectrometry (GC-MS) analysis to determine the structure, melting point, and molecular mass of the purified compounds. Conclusions: The crude extracts and purified compounds from the sandalwood holds potential as medications for various antifungal therapeutics. However, further research on their potential incorporation into different preparations, safety and cost- effectiveness remains to be...
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Posted by admin on Jun 30, 2016 in |
Mentha piperitais currently one of the most economically important aromatic and medicinal crops in all over the world. Phytochemical investigation of the leaves of Mentha piperita (L.) (Lamiaceae) yielded a new compound, which is decarboxyrosemarinic acid galactoside. Formulate as 3’, 4’-dihydroxy-β-phenyl ethyl caffeate-4-(3’’’-menthyl)-4’-β-D-galacto pyranoside. 13C NMR, 1H NMR, FABMS, IR were used for structural characterization. Wound healing responses of this compound was evaluated from biochemical as well as biophysical parameters and analyze the role of isolated compound. The parameters studied included rate of wound contraction and the period of epithelialization in excision wound model. Tissues were removed on different days of intervals and subsequently analyzed for specific assays Tensile strength in incision wound model was assessed along with histopathological examinations. Compound-1was found to increase the cellular proliferation and collagensynthesis at the wound site, as indicated by increases in amounts of DNA synthesized, protein content. Compound-1treatment was also shown to decrease the levels of lipid peroxides (LPs), while the activity of enzymes superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase...
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Posted by admin on Jun 30, 2016 in |
Paracetamol tablets are popular over the counter (OTC) products among the patients as a good analgesics and antipyretics. The objective of this study was to compare the quality of the paracetamol tablet formulations those are locally available in Trinidad & Tobago pharmaceutical market manufactured by various pharmaceutical companies with pharmacopoeia standards. The four popular brands (A, B, C, D) of paracetamol conventional tablet of 500 mg strength were chosen. The paracetamol tablets were obtained from government hospital pharmacies as well as from local private pharmacies. To compare the quality of tablet formulations of different brands various official parameters like friability, weight variation, disintegration time, dissolution and drug assay tests were performed as per the pharmacopoeia. The result of all these parameters of different brands were in the pharmacopoeial limits so it could be concluded that marketed pharmaceutical tablets of paracetamol of these brands are safe, effective and efficacious as well as satisfy quality control limits of...
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Posted by admin on Jul 5, 2015 in |
Alpinia galanga Linn. (Zingiberaceae) presents many chemical constituents of the volatile oil extracted from the rhizome. The rhizome of Alpinia galanga is used by people in many regions for relieving toothache, abdominal pain, muscular swelling and rheumatism. This study was performed to determine the antinociceptive and anti-inflammatory activities of a methanolic extract of Alpinia galanga. Analgesic activity was evaluated by acetic acid induced writhing responses, tail flick and hot plate methods in mice. In analgesic activity the A. galanga extract significantly reduced the writhes and increased the tail withdrawal time and paw jumping in albino mice. The anti-inflammatory activity was evaluated by carrageenan induced edema in wistar albino rats. It was found that the extract inhibits the paw edema significantly (p<0.05) at both 250 mg/kg and 500 mg/kg dose levels when compared with control. The positive control drugs for analgesic and anti-inflammatory studies were employed as morphine and indomethacin, respectively. The present findings indicate the antinociceptive and anti-inflammatory effect of A. galanga extract in...
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