Posted by admin on Jun 30, 2018 in |
Objective: The persistence of this effort was to frame, evaluate and examine the impact of natural and semi-synthetic polymer in changing the release rates of matrix tablet loaded with diclofenac sodium. Materials and method: Matrix tablets of diclofenac sodium were made-up by varying the concentrations of both natural polymer i.e Guar gum and semi-synthetic polymer i.e HPMC K4M via straight compression method. Optimization of the tablet was completed by taking quantity of Guar gum and HPMC K4M in percentage as self-governing variable and cumulative percent of drug release at 2 hr, 6 hr and 12 hr as faithful variable using design expert Software. Optimized tablet was assessed for various pre and post compression limitations equated with marketed formulation. Drug release kinetics of the optimized tablet was evaluated by various representations of drug release kinetics. Result: The verdict of present investigation evidently designates that by using both natural and semi-synthetic polymer in a same tablet was given a noteworthy sustained release. The dissimilarity with the optimized formulation in software data...
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Posted by admin on Jun 30, 2018 in |
Toxoplasmosis is a parasitic disease with global prevalence that is caused by a unicellular organism called Toxoplasma gondii. Given the high prevalence of the disease in the country, particularly in pregnant women, and severe complications of the disease for the fetus, congenital type, the disease consequences for patients taking medications that suppress the immune system as well as side effects caused by common treatment methods, discovery of new drugs with minimal side effects seems to be necessary. In this study was an attempt to investigate the effect of tylosin on toxoplasma in-vivo environment. 200000 parasites (tachyzoite form) were subcutaneously injected to 60 Balb/C mice that were divided into 6 groups (each consisting of 10 samples). Tylosin with four different concentration levels (10-80 mg/kg) was intraperitoneally injected. One of the groups was tested without injection of medicine and another group was tested with sulfadiazine and the disease process was carefully investigated in these groups. Comparison of treatment groups with the control group and statistical analysis of data showed a significant...
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Posted by admin on Jun 30, 2018 in |
Neurodegenerative disorders particularly Parkinson’s disease are serious threat for heath society. In addition, treatment, control and managing of Parkinson’s disease burden high cost to these patients. Therefore, an efficacy and available treatment strategy is required so that herbs and their bioactive compounds could be good candidates. It has well been demonstrated the herbs are a potential source of antioxidant and have anti-inflammatory property. Interestingly, oxidative stress and inflammation are main reasons neurodegeneration in substantia nigra pars compacta. Here, we review the studies conducted on effects of extracts and compounds obtained from herbs in treatment of Parkinson’s disease until 2000 to now by to focus on their effects on different animal model of Parkinson’s...
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Posted by admin on Jun 30, 2018 in |
Dental caries is a complex disease which is expressed as an interaction between various factors including the host, agent, substrate and time. The interplay between the dental biofilm and oral microorganisms is an important feature for development of a cariogenic dental plaque. Formation of the biofilm needs to be controlled through regular brushing in order to prevent the development of caries and periodontal diseases. Hence a study was conducted to evaluate and compare in-vivo the effect of two commercially available herbal and non-herbal (fluoridated) toothpastes on salivary bacterial count in 5 – 10 years age children with 3 – 6 decayed teeth. 40 children were randomly allocated into two groups I and II. Group I were provided with Fluoridated (Kidodent) toothpaste and Group II with Herbal (Babool) toothpaste. Participants were scored for plaque index and saliva sample was collected as the baseline score (day 0). After demonstration of brushing technique participants were asked to brush twice daily. The plaque index score and saliva sample was once again collected at...
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Posted by admin on Jun 30, 2018 in |
The first case of middle east respiratory syndrome (MERS) was identified in a mid-aged Saudi Arabian resident in 2012. The syndrome is analogous to severe acute respiratory syndrome (SARS) in its clinical course, with a male predominance in incidence. MERS virus is disseminated as a result of close proximity of people to camels, person to person transmission being uncommon and confined to hospital settings. The incubation period usually lasts for 2 – 14 days. MERS-CoV appears to be an enzootic virus, tracing its origin to bats, whereas camels may act as intermediate hosts. Typical flu-like symptoms are observed, which include pyrexia, myalgia, apnoea and cough. Symptoms advance over time leading to multiple organ failure, septic shock and eventually death. Diagnosis can be done with the aid of recombinant IgA and IgG ELISAs, and other specific assays such as upE and real-time Reverse Transcription (rt-RT) PCR assay. Currently, neither an authorized vaccine nor a definitive treatment is available for human use. However, adenosine deaminase, mycophenolic acid (MPA), cyclosporine A, nelfinavir,...
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