Posted by admin on Aug 1, 2013 in |
The present study deals with the antioxidant activity, drug likeness score and bioactivity score of the compounds isolated from Curcuma longa and search lead antioxidant compound through molinspiration software. We have taken ten compounds from this plant. All the compounds were further subjected to molecular properties prediction and drug likeness by Molinspirstion and found in compliance with Lipinski’s rule of five. The compounds IV, V, IX, X fulfill Lipinski’s rule and show good drug likeness score. Milog P of these compounds was found below 5 that means these shows good permeability across cell membrane. TPSA below 160 Ǻ2, n violatios =1 or <0 it means compound easily bind to receptor, molecular mass <500, n rotb < 5 [10], Number of hydrogen bond donors ≤ 5 (The sum of OHs and NHs), Number of hydrogen bond acceptor ≤ 10 (The sum of Os and Ns). Compounds I-X were taken further calculation of bioactivity scoreby calculating the activity score of GPCR ligand, ion channel modulator, nuclear receptor legend, kinase inhibitor, protease...
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Posted by admin on Aug 1, 2013 in |
As the conventional treatment is associated with large number of side effects, herbal treatment is gaining popularity particularly in the treatment of chronic disease like jaundice, vitiligo, rheumatoid arthritis, asthma etc. Herbal treatment has been identified as safe and effective in treating such disease. The aim of this study was to review systematically the evidences and effectiveness of herbs used in the treatment of different forms of arthritis and their anti‐inflammatory or anti‐arthritic properties have been evaluated clinically. A number of plants have been identified as anti-inflammatory and anti-arthritic, but only few of them have evidence of clinical trial. We searched the following electronic database Cochrane Complementary Medicine Field Register; Cochrane Controlled Trials Register (CCTR); and MEDLINE for our study. The reviewed herbs appear relatively safe, further research is needed to examine their efficacy, safety and potential drug...
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Posted by admin on Aug 1, 2013 in |
Olmesartan medoxomil (OLM) is an angiotensin II receptor blocker used for the treatment of hypertension. In this work an attempt was made to mask the metallic taste and enhance the solubility and dissolution rate of poorly soluble OLM by formulating it as inclusion complexes with β-cyclodextrins (β-CDs) as complexing agent in 1:1 molar ratio. The drug – CDs complexes were prepared by physical mixing and co-evaporation methods. The complex formation with in solid state was confirmed by Fourier transform infrared spectroscopy, x-ray diffractometry, differential scanning colorimetry and by scanning electron microscope analysis. From the prepared inclusion complexes, orodispersible tablets (ODTs) were formulated by using various superdisintegrants like sodium starch glycolate (SSG) and crospovidone in various concentrations (5-15%). Prepared tablets were evaluated for physical parameters and drug release by in vitro dissolution studies. ODTs containing SSG (15%) as super-disintegrant showed fastest disintegration and in vitro drug release. In conclusion, the present investigation demonstrates that the combination of inclusion complexation and using of superdisintegrants was a promising approach in the preparation...
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Posted by admin on Aug 1, 2013 in |
The main goal of this study was to develop a stable formulation of model antibacterial drug as an immediate- release tablet systematically using Quality by Design approach of which design of experiments is an integral part. The model drug was found to be a BCS class II drug official in USP having a plasma half-life of three to four hours. The formulation development work was initiated with wet granulation method and a total of three trials were conducted to determine the critical material attributes of the formulation used as factors for the experimental designs. The binder (Povidone K29/32,), Superdisintegrant (Crosscarmellose Sodium), Lubricant (Stearic acid and magnesium stearate), Pregelatinized Starch 1500 (binder and disintegrant) were determined to be critical for the formulation of the model antibacterial drug. A fractional factorial design (FFD) for four factors at two levels was selected to screen the varied response variable. A total of eight trials were conducted (24-1FFD).The four factors viz. Povidone K29/32(X1), Crosscarmellose Sodium (X2), lubricant ratio (X3) and Pregelatinised starch 1500 IG:EG...
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Posted by admin on Aug 1, 2013 in |
Pharmacogenetics (PGt) is an established discipline that studies the genetic basis of inter-individual variability in the response to drug therapy and pharmacogenomics (PGx) is the branch of pharmacology which deals with the influence of genetic variation on drug response in patients by correlating gene expression or single-nucleotide polymorphisms with a drug’s efficacy or toxicity. The goal of personalized medicine is to maximize the likelihood of therapeutic efficacy and to minimize the risk of drug toxicity for an individual patient. Many unexpected pharmacodynamic responses and pharmacokinetic variations among individuals during drug therapy involve genetic factors. These genetic factors contribute to variations at many levels, including drug transport, metabolism, and interaction at the receptor site. Understanding and monitoring the underlying pharmacogenetic factors will allow physicians to optimize efficacy and minimize side effects. In March 2005, the FDA released its final version of the “Guidance for Industry: Pharmacogenomic Data Submissions” clarifying what type of pharmacogenomic data needs to be submitted to the FDA. In addition, the guidance, for the first time, encourages...
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