Posted by admin on Jul 31, 2025 in |
Till the nineteenth century, people worldwide were relying on herbal medicines for their health problems. Today, it is common knowledge that different parts of plants contain various phytochemicals. Phytochemicals exhibit variety of physiological activities and health benefits. Due to the side effects shown by synthetic medicines, there is increased interest in phytopharmaceuticals. There are many instances where natural chemicals have played important role in new drug discovery. Chemical modification of pharmacophore in naturally occurring drug has resulted into new drugs with better drug properties. Ellagic acid is a phytochemical belonging to polyphenol class. It shows many biological and medicinal activities including antioxidant, anti-inflammatory, anti-cancer, neuroprotective, anti-diabetic. Hepatoprotective, cardioprotective, skin protective effects. It contains lactone rings, aromatic rings in form of biphenyl unit and four phenolic hydroxy groups. The two new derivatives of ellagic acid are prepared. In the first one, benzoylation of all four phenolic hydroxy groupis carried out giving tetrabenzoyl ellagic acid. In the second, the lactone rings are opened by base hydrolysis forming aoctasodium salt of hydrolysed...
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Posted by admin on Jul 31, 2025 in |
Vitiligois depigmentation disorder, and it causes loss of melanocytes. Denaturation of melanocytes caused by oxidative stress, genetics, auto immune response and then synthesis of inflammatory mediators. Vitiligo is classified into two types segmental and non-segmental. There is various treatment to cure vitiligo and some treatment causes side effects. So, through herbal plants we can cure the diseases the herbal plants are Ginkgo biloba, Nigella sativa, Psoralea corylifolia there are plants which has antioxidant properties, anti-inflammatory, these antioxidant helps to neutralizes free radicals and reduce oxidative damage in the skin. Psoralea corylifolia it has ability to stimulate melanin production in the skin through this repigmentaion occurs in the skin. In the pursuit of developing effective treatments for vitiligo, understanding the chemical composition and molecular structure of a topical formulation is essential. GC-MS analysis is used to identify the compound present in polyherbal lotion, FT-IR spectroscopy is used to analzye the functional group present in the lotion, HPLC quantitative analysis is used to determine exact amount of active ingredients present in...
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Posted by admin on Jul 31, 2025 in |
Introduction: The use of traditional herbal medicines in conjunction with modern pharmaceuticals is a growing trend. However, the concurrent use of these therapies can lead to significant pharmacological interactions affecting drug metabolism, efficacy and safety. Objective: This systematic review aims to provide a comprehensive overview of pharmacological interactions between traditional herbal medicines and modern pharmaceuticals, highlighting common interactions, elucidating underlying mechanisms and offering clinical recommendations. Methods: A systematic search was conducted in databases including PubMed, MEDLINE and the Cochrane Library for studies published up to July 2024. The review included clinical trials, observational studies, and reviews that examined interactions between herbal medicines and pharmaceuticals. Data were extracted and assessed for quality using the Cochrane risk-of-bias tool and the Newcastle-Ottawa Scale. Results: Out of 3,245 records identified, 50 studies were included in the qualitative synthesis and 20 studies were included in the quantitative synthesis. Common herb-drug interactions were identified, such as St. John’s Wort with antidepressants and anticoagulants, Ginkgo Biloba with anticoagulants and anticonvulsants, and Ginseng with antidiabetic drugs and...
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Posted by admin on Jul 31, 2025 in |
The use of topical drug delivery systems is becoming increasingly popular due to their convenience and effectiveness. However, the potential of proniosomal gel for delivering econazole nitrate topically has not been widely studied. This study focuses on designing and optimizing a proniosomal gel formulation of econazole nitrate to improve antifungal therapy. The proniosomal gel was prepared using the coacervation phase separation method, incorporating Span 60, cholesterol, and other ingredients. The ratio of non-ionic surfactants to cholesterol significantly affects drug entrapment efficiency and release characteristics. The formulated proniosomes were evaluated for parameters such as entrapment efficiency, vesicle size, and in vitro drug release. Optimization using a central composite design examined the impact of varying Span 60 and cholesterol ratios on these properties. The optimized formulation showed a sustained drug release of 12 hours and a high entrapment efficiency of 95.41% at an optimal Span 60-to-cholesterol ratio of 6.65:1. The vesicles were found to be discrete and spherical. Additionally, the optimized formulation demonstrated superior antifungal activity, showing a larger zone of...
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Posted by admin on Jul 31, 2025 in |
Green Nanotechnology techniques have emerged in response to the growing need for sustainable and eco-friendly approaches to synthesize nanoparticles. The present study provides an endurable procedure for the green-mediated synthesis of silver nanoparticles (AgNPs) from Albizia amara leaf extract and its antibacterial potential. Various techniques like UV-Vis spectroscopy, FT-IR, XRD and FE-SEM were employed to characterize the properties of the silver nanoparticles. The UV-Vis spectra exhibited a maximum peak for AgNPs at 425nm, confirming their absorption capability. The presence of OH and COOH functional groups was evident from the FT-IR analysis which contributes to the stability of nanoparticles. The XRD patterns displayed distinct diffraction peaks. The morphology of AgNPs was determined by FE-SEM and the elemental composition of synthesized nanoparticles was exhibited in EDS mapping. When the silver nanoparticle was tested against the clinical pathogens, the results demonstrated a considerable inhibition of bacterial growth. The magnitude of the zone of inhibition exhibited by silver nanoparticles showed high antibacterial activity with zones measuring 19mm against Enterococcus faecalis strain. The results...
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