Posted by admin on Jul 31, 2025 in |
An efficient and high yield synthesis of Siamenoside I (1), from Mogroside V (2) is reported. Siamenoside I (1) was obtained by enzymatic hydrolysis of Mogroside V (2). Bioconversion process involved enzymatic modification followed by separation and purification processes, including reversed-phase chromatography. The final product, a dried white powder, undergoes several stages of concentration, reaction, filtration, and freeze-drying. Siamenoside I (1) was isolated and characterized with NMR (1H, 13C, 1H-1H COSY, 1H-13C HSQC-DEPT, 1H-13C HMBC, 1H-13C HSQC-TOCSY, 1H-1H ROESY and 1D-TOCSY) and mass spectral data. This Siamenoside I (1) possess a 1->2 beta sugar linkage between sugar II and sugar I, making it’s structural properties unique. The sensory and spectral properties of Siamenoside I (1) synthesized from mogroside V (2) or isolated from fruit have the same characteristics. Additionally, we emphasize the importance of 1D and 2D NMR techniques when identifying complex...
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Posted by admin on Jul 31, 2025 in |
Micronutrient deficiencies are an important driver of morbidity and mortality associated with non-communicable diseases. According to the World Health Organization, more than two billion individuals are micronutrient deficient worldwide, with India home to over half of them. India needs to actively fight against the severe effects of malnutrition since, despite the nation’s strong economic growth and declining poverty rate a sizeable section of the population still has sub-optimal nutrition. This review primarily focuses on the current situation of micronutrient status in the nation, including driving factors that contribute to micronutrient deficiency, clinical perspective and challenges, role of supplementation, long-term and sustainable strategies to reduce micronutrient deficiency, as well as challenges in adapting the micronutrient supplementation practices as in the developed world by the Indian community. To achieve India’s optimum nutritional status, it is required to identify strategic initiatives to overcome practical challenges and implement the right balance of biofortification, nutritional diversification, and sufficient...
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Posted by admin on Jul 31, 2025 in |
A topical drug delivery system involves applying medication to the skin for therapeutic effects or to treat skin disorders. Traditional gels often struggle to deliver hydrophobic drugs effectively, a challenge that can be overcome with emulgels. Emulgels, which combine emulsions and gels, create a dual-release control system that enhances medication efficacy. This innovation is essential in topical delivery systems, significantly improving bioavailability and patient compliance. Emulgel are widely utilized in numerous cosmetic products and for medical applications such as analgesic, antifungals, anti- inflammatory and anti-acne therapies. These topical administration systems have the major benefit of being able to avoid first-pass metabolism, which increases the active compounds’ bioavailability. Emulgels are non-greasy, thixotropic, and easily spreadable, having beneficial qualities for dermatological uses. They also have a longer shelf life because they are water-soluble, emollient and simple to remove. Emulgels are a noteworthy advancement in the field of topical drug administration because of their translucent and visually pleasant look, which also improve user experience. It is a very productive area of research...
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Posted by admin on Jul 31, 2025 in |
The aim of this study is to assess the antibacterial efficacy of the Datura stramonium seeds and leaves extracts against Mycobacterium kansasii. The antimicrobial experiments were performed using five doses (0.25µg/ml, 0.50µg/ml, 1µg/ml, 2µg/ml, 4µg/ml) of seeds and leaves extracts. The results showed notable inhibitory effects on Mycobacterium kansasii. The results indicated that the extract of D. stramonium exhibited action against all the tested bacterial isolates, with the level of activity varying depending upon the concentration. The hexane extract of seeds DSS-1H exhibited antibacterial activity, with mean zones of inhibition measuring 98.94±50.25.%, 120.98±56.92%, 120.499±69.60%, 125.752±133.18% and 89.494±180.63%, at the doses of 0.25, 0.50, 1, 2, and 4 µg/ml and while treating with DSS-2A the percent cell viability of the microbial cell was found to be 128.02±25.64%, 86.79±14.95%, 34.61±16.33%, 26.29±29.76% and 32.56±19.48% at the doses of 0.25, 0.50, 1, 2 and 4µg/ml, respectively, with incubation period of 48 hours. Similarly, the microbial cells were treated (0.25, 0.50,1,2,4 µg/ml) with DSS-3ET with incubation period of 48 hours, indicating a more substantial...
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Posted by admin on Jul 31, 2025 in |
Aquasomes are a highly advanced nanoparticulate transport system in nanotechnology. It is mostly utilized for medication delivery. These carriers are differentiated by their three-layered structure, which includes a solid nanocrystalline core (often calcium phosphate or ceramic diamond), a polyhydroxyoligomeric film, and functional properties. The core is solid mechanical strength and stability, but the carbohydrate covering protects the bioactive compounds from dehydration and denaturation. Aquasomes are typically ranging from 60 to 300nm, making them appropriate for a variety of biomedical applications. One of the key benefits of aquasomes in their capacity to deliver medicines, proteins, peptides and genes to particular locations in the body with high precision. This tailored delivery technology increases medicinal efficacy while minimizing negative effects. Additionally, aquasomes provides delayed and prolonged release of the encapsulated compounds, which improves overall treatment outcomes. Aquasomes have demonstrated great potential for delivering insulin, vaccinations and other medicinal substances. Their biocompatibility and capacity to maintain the stability of sensitive molecules make them an adaptable tool in creation of improved drug delivery...
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