Posted by admin on Aug 1, 2012 in |
The aim of the study is to observe the cytotoxic activitiy of methanolic crude extracts of root of Justica adhatoda a plant belonging to the family Acanthaceae. The root of Justica adhatoda was extracted with organic solvent and the extracts were used for the observation of cytotoxic activitiy. Crude extracts (n-hexane, ethyl acetate and chloroform soluble fraction) of Justica adhatoda, were screened for cytotoxic activity using brine shrimp lethality bioassay. A reputed cytotoxic agent vincristine sulphate was used as a positive control. From the results of the brine shrimp lethality bioassay it can be well predicted that n-hexane, ethyl acetate and chloroform soluble fraction of methanolic crude extracts possess cytotoxic principles (with LC50 1.129mg/ml, LC50 1.402 mg/ml and LC50 2.130 mg/ml respectively) comparison with positive control vincristine sulphate (with LC50 0.563...
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Posted by admin on Aug 1, 2012 in |
A simple, economic, selective, precise, and accurate High Performance liquid Chromatographic method for the analysis of Doxazosin in bulk drug and pharmaceutical formulations was developed and validated in the present study. The mobile phase consists of a mixture of Methanol and Potassium Dihydrogen Orthophosphate in the proportion 60: 40. And adjust the pH to 5.0 ± 0.05 with sodium hydroxide solution. This was found to give a sharp peak of Doxazosin at a retention time of 4.484 min. HPLC analysis of Doxazosin was carried out at a wavelength of 251nm with a flow rate of 1.0mL/min. The linear regression analysis data for the calibration curve showed a good linear relationship with a regression coefficient of 0.999 in the concentration range of 50 ppm to 150 ppm. The linear regression equation was y =28.34x-16.91. The developed method was employed with a high degree of precision and accuracy for the analysis of Doxazosin. The developed method was validated for accuracy, precision, robustness, detection and quantification limits as per the ICH guidelines. ...
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Posted by admin on Aug 1, 2012 in |
Modified Release (MR) Formulations have a modification in the release mechanism. Modified release dosage forms are developed by altering drug absorption or the site of drug release in order to achieve predetermined clinical objectives. Modified drug release from dosage forms is complemented by the allied processes of drug design, of dosage administration, and of membrane transport and absorption of drug to the biological site of action.Modified-release drugs have complex formulations that can offer an advantage over standard medication for some patients. Modified-release preparations should only be used where there is a clear clinical advantage over conventional-release preparations. In general, Modified-release preparations should be reserved for specific patients where there is a problem with compliance, effectiveness or side-effects which these preparations could help overcome. Modified–release technologies have become indispensable to resolving critical technical, therapeutic, and marketing challenges, such as improving patience compliance, less dosage timings, better safety, better indications, delivering poorly soluble and poorly absorbable API’s, product differentiation, patent protection, product life-cycle extension, and better margins. Modified-release formulation design can...
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Posted by admin on Aug 1, 2012 in |
QSAR study of lipid peroxidation (LPO) inhibitory activity of 18 flavonoids belonging to four classes namely flavones, isoflavones, flavonols and flavanones has been made with the help of PM3 calculations and geometry optimizations using CAChe software. Quantum-chemical descriptors were calculated by the same software using MOPAC 2002 engine. Two quantum-chemical descriptors, molar volume (M.V.) and dipole moment (μ) and two new indicator descriptors of electron densities on carbon and oxygen atoms are used for QSAR analysis. The results are highly encouraging as average values of correlation and cross validation coefficient are 0.794 and 0.754. Four QSAR models have high predictive power while one model has average predictability. These models can successfully predict the antioxidant activity of any newly discovered flavonoid which can later be tested in laboratory....
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Posted by admin on Aug 1, 2012 in |
Metabolic Syndrome is a cluster of several cardiovascular risk factors that include glucose intolerance, central obesity, dyslipidemia, and hypertension. The public health impact of this syndrome is weighty; given it is a primary risk factor for cardiovascular diseases, obstructive sleep apnea, and type II diabetes. This current plight is further underscored by recently emerging evidence that Metabolic Syndrome is also associated with albuminuria and increasing incidence of chronic kidney disease, Moreover, this relationship persists even after exclusion of individuals with diabetes. Thus, Metabolic Syndrome is an independent risk factor for the development of chronic kidney disease, in the absence of diabetes, and independent of hypertension. ...
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