Posted by admin on Sep 1, 2013 in |
Bromocriptine mesylate quick release formulation has recently been approved by FDA for the treatment of diabetes mellitus. Till now it has been mainly known for its use in Parkinsonism and for suppression of lactation. Present study evaluates and compares the antihyperglycemic effect of the combination of bromocriptine and metformin with either of the two drugs taken alone. For this fasting blood sugar level of all the groups were measured on day 1,7,14 and 21 of treatment. In this study all the three treatment groups was found to have significant (P<0.05) blood glucose lowering effect. Fall in fasting blood was less in bromocriptine treated group as compared to groups treated with metformin and those treated with combination of the two. It is concluded that hypoglycemic effect of combination of metformin and bromocriptine is better than either of the two drugs taken alone. This may be due to potentiation or synergism between metformin and bromocriptine. Further studies are required to prove that bromocriptine has constantly significant hypoglycemic effect with better safety...
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Posted by admin on Sep 1, 2013 in |
The present work deals with antifertility effect of the aqueous extract of Indigofera trifoliata leaves in female albino rats. Pregnant rats weighing 120 to 200 gm were randomized into 4 groups. From day 11 upto day 15 of pregnancy, rats were laprotomised on 10th day of pregnancy and live fetuses were observed in both the horns of the uterus. Rats in group 1 (control) were orally administered, with 0.5 ml of distilled water once daily while those in group 2 to 4 (experimental groups) were administered 100, 200 and 400 mg/kg body weight doses of aqueous extract of I. trifoliata leaves respectively. Then the animals were allowed to go full term. The effect of aqueous extract of I. trifoliata leaveson estrogenic and antiestrogenic activity and estrous cycle was observed to confirm the antifertility activity. The aqueous extract of I. trifoliata leavesexhibited significant antifertility activity (28.50 to 92.30%). It was found that the extract significantly reduced the number of live fetuses, whereas the resorption index and post implantation losses increased...
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Posted by admin on Sep 1, 2013 in |
To assess the adverse drug reactions (ADRs) induced by antitubercular drugs used in Directly Observed Treatment Short Course (DOTS) from previously reported 8 articles from referred sources. Articles related to adverse drug reactions induced by first line anti- tuberculosis drugs in DOTS therapy published during 2002 to 2012 were searched. The incidence rate of each type of ADR from entire ADRs were analyzed and compared. The total 10083 patients from 8 studies were studied, out of those 7473 (74.11%) patients showed at least one type of ADR. The majority cases of ADRs were dermatological reactions occurred in 4389 (43.52%) patients followed by hepatotoxicity in 1634 (16.20%) patients, other reactions related to gastrointestinal (GI) in 1004 (9.95%) patients, central nervous system in 86 (0.85%) patients,peripheral nervous system in 07 (0.069%) patients, psychiatric in 03 (0.029%) patients, musculoskeletal in 166 (1.64%) patients, renal in 07 (0.069%) patients, otological in 09 (0.089%) patients, ocular in 29 (0.28%) patients, fever in 13 (0.12%) patients, breathlessness in 04 (0.039%) patients, headache in 37 (0.36%) patients...
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Posted by admin on Sep 1, 2013 in |
Simple, sensitive and convenient spectrophotometric methods (method A and method B) are developed for the determination of diclofenac diethylamine (DDEA) in pure form and in formulations. Method A is based on the oxidation of drug by Fe(III) followed by the complex formation between reduced form of Fe(III) with 1,10-phenantroline. The resulting red colored chromogen is measured at 510 nm. Method B is based on the formation of charge transfer complex between DDEA (n-donor) and p-chloroanilic acid (π-acceptor) in 1,4-dioxane. The resulting violet colored chromogen is measured at 526 nm. Beer’s law obeyed in the concentration range of 2.00-8.00 and 20.00-120.00 µg mL-1 for the method A and B, respectively. The molar absorptivity and Sandell’s sensitivity are found to be 0.98 × 104, 1.62 × 103 L mol-1 cm-1 and 3.77 × 10-2, 2.27 × 10-2 µg cm-2 for the method A and B, respectively.The optimum reaction conditions and other analytical parameters are evaluated. Statistical analysis proves that both the methods are reproducible and selective for the determination of DDEA...
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Posted by admin on Sep 1, 2013 in |
An accurate, simple and precise RP-HPLC method for the simultaneous determination of telmisartan and hydrochlorothiazide in pharmaceutical formulations was developed and validated. Chromatographic separation of two drugs was achieved on a Kromasil C18, (250×4.6nm, 5µm) column by using the mobile phase consisted of methanol, tetrahydrofuran and water in the ratio 55:05:40 at a flow rate of 1mL/min and the wavelength of detection was at 234 nm. The retention time for telmisartan and hydrochlorothiazide were found to be 2.3 and 3.8 min respectively. The linearity of the developed method was tested over a concentration range of 50-100 µg/mL and the correlation coefficient (r2) of regression was 0.999 which is almost equal to 1. The limit of quantification was 0.5µg/mL for telmisartan and 0.4µg/mL for hydrochlorothiazide and the limit of detection was 0.1µg/mL for both telmisartan and hydrochlorothiazide. The mean percentage recoveries were 99.2% for telmisartan and 99.8% for hydrochlorothiazide...
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