Posted by admin on Sep 1, 2013 in |
This work has been undertaken for the screening and isolation of fibrinolytic protease producing mesophilic bacteria from ten soil samples, collected from slaughter housesvarious regions of Bangalore and used to screen for fibrinolytic protease production by using fibrin plate assay. In the present study, an attempt was made to isolate efficient fibrinolytic protease producing bacteria from diverse environmental samples. Different isolates were screened for possessing the ability to produce fibrinolytic protease. About 5 bacterial isolates were found to be promising to produce fibrinolytic protease. The organisms were tested for various biochemical tests, which leads to their identification as Bacillus cereus, Bacillus circulans, Pseudomonas aeruginosa, Pseudomonas fluorescens and E.coli....
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Posted by admin on Sep 1, 2013 in |
Complexes of Copper (II) halides with steryl derivative of 2- methylbenzimidazole (stmbz), 2-ethylbenzimidazole (stebz) and 2-benzylbenzimidazole (stbbz) of composition CuL2X2 (L = stmbz, stebz and stbbz and X = Cl, Br) have been prepared and characterised. The magnetic susceptibility e.p.r. data, electronic absorption pattern and i.r. spectral studies of complexes indicated distorted octahedral environment of ligand around copper (II) atom. Steryl derivatives and their copper (II) complexes were screened for their antifungal activity in dilute aqueous ethanolic media where bromide complexes show higher antifungal activity than free...
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Posted by admin on Sep 1, 2013 in |
The present study reports an environmentally friendly, microwave-assisted rapid green synthetic method using Saraca indica leaf extract makes a fast and convenient method for the synthesis of silver nanoparticles and can reduce most of the silver ions into silver nanoparticles within 180 sec of reaction time with the aid of microwave. The synthesized nanoparticles were characterized using UV-visible (UV-vis) spectrophotometer, Transmission electron microscopy (TEM), X-ray diffraction (XRD) and Fourier transform infra-red (FTIR) spectrometry. The nanoparticles were found to be spherical in shape and of 5 to 50 nm in size. The synthesized silver nanoparticles exhibited good antibacterial potential against both Gram positive and Gram negative bacterial strain as measured using well diffusion...
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Posted by admin on Sep 1, 2013 in |
This research aims to detect the in-vitro antioxidant activity of the methanolic and aqueous stem extract of Rotula aquatica lour and to estimate its phenolic and flavonoid content. DPPH (2, 2-diphenyl-1-picryl hydrazyl), superoxide radical scavenging capacity and reducing power assay (RPA) were carried out to evaluate in vitro antioxidant activity. Phytochemical screening was carried out according to standard procedures followed by their TLC profiling was carried out. Total phenolic content was estimated by using Folin-Ciocalteu’s reagent and total flavonoid content by Aluminium chloride colorimetric method. It was observed that DPPH and superoxide IC50 value of methanolic and aqueous stem extracts of Rotula aquatica lour were found to be (50.98±0.19)µg/ml, (73.67±0.12)µg/ml and (65.41±0.42)µg/ml, (71.97±0.31)µg/ml respectively and reducing power of the extract was increased with the increasing concentration. Total phenolic and flavonoid contents were found to be 6.80 g and 5.90 g gallic acid equivalent per 100 g and 2.60 g and 1.79 g quercetin equivalent per 100 g of methanolic & aqueous extract respectively by spectrophotometric method. These primary findings...
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Posted by admin on Sep 1, 2013 in |
The core moiety of ritonavir (2S, 3S, 5S)-5-(tert-butyloxycarbonyl)amino-2-amino-3-hydroxy-1,6-diphenylhexane (7) on condensation with oxirane of carbazole (8) in isopropyl alcohol at reflux and deprotected with mineral acid gave compound 10. Coupling of compound 10 with carbamate amino acid (11a-15c) in the presence of EDAC.HCl and HOBt at room temperaturegave ritonavir analogues containing carbazole (16a-20c) as a novel for the human immunodeficiency virus (HIV)-1. These compound were characterized by IR, 1H NMR and Mass...
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