Posted by admin on Aug 31, 2024 in |
A fast, efficient and defined method was developed for the real-time assessment of Sitagliptin in tablet dosage form. Dissolution method was developed and carried out to predict in-vivo drug release profiles of Sitagliptin tablets. Rate and extent of dissolution of Sitagliptin tablets was studied in different dissolution medias i.e. 0.1 N HCL, pH 4.0 Acetate buffer and pH 6.8 Phosphate buffer using USP Type 1 dissolution apparatus with a RPM of 100. Ultra performance liquid chromatography was performed using BEH C18 Column (2.1x 50mm, 1.7µm). Moving phase containing Phosphate Buffer of pH 7.2, Acetonitrile and Methanol in ratio 60:20:20v/v/v was pumped through the column at 1 mL/min flow rate. Run time is 3 minutes. Injection volume is 1.7μL and column is maintained at a temperature of 25°C. Selected wavelength is 210 nm. The Dissolution method was developed and validated and was found to be Precise, Accurate, Linear in a Concentration Range of 25 % to 175 % of Test concentration. Sitagliptin retention time was found to be 1.592 minutes....
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Posted by admin on Aug 31, 2024 in |
In the pharmaceutical industry, combinatorial chemistry has emerged as a novel approach, facilitating the synthesis of multiple compounds simultaneously rather than focusing on individual compound. The quick production of the chemical means that this technology reduces the time and expense involved in drug research. In this review article, the topic of combinatorial chemistry is discussed in general terms, along with the concepts of combinatorial libraries, methodologies and applications. This technique significantly lowering the cost involved in new drug research and increases the chances of finding new lead molecules. Most commonly used combinatorial techniques are solid phase synthesis, Parallel synthesis, mixed combinatorial synthesis and solution phase synthesis. Combinatorial chemistry is useful for the efficient detection of big molecules as well as the production of tiny molecules and peptides. The aim of this project is to give a fundamental overview of combinatorial chemistry, outlining the evolution of key methods and a few...
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Posted by admin on Aug 31, 2024 in |
Medicinal plants are important for pharmacological research and drug development. Aim and Objective: The aim and objectives of present study was to evaluate the wound healing activity of seed oil of Azadirachta indica in Excision and Incision wound models in rats. Result Discussion: The study thus demonstrated the wound healing activity of Neem seed oil and found to be effective in the functional recovery of the wound. It promotes wound contraction of excision wound as compared to control...
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Posted by admin on Aug 31, 2024 in |
A non-nucleoside reverse transcriptase inhibitor (NNRTI) is Nevirapine. Zidovudine and Lamivudine are antiretroviral medications that are members of the nucleoside analogue class. Combination of three drugs commonly used in the management of the Human Immunodeficiency Virus (HIV) infection. Nevirapine exhibits a decent initial release, while Zidovudine and Lamivudine demonstrate sustained release in the produced trilayer and bilayer tablets. The outcome demonstrates that the release profile is not affected by layer separation and is highly dependent on the drug to polymer ratio. The results show that the release can be effectively controlled for up to 12 hours using a 1:1 ratio of zidovudine and HPMC and a 1:1 ratio of lamivudine and ethyl cellulose. It is clear that formulation F1, out of all formulations, has the best sustained release, drug content, and highest regression values. Nevirapine fits best in first order release of Zidovudine in all of the F1–F6...
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Posted by admin on Aug 31, 2024 in |
“Similia Similibus Curentur,” is the therapeutic law of nature on which Homoeopathy is based. This means “Let like be treated by likes,” with a holistic and dynamic concept. As mentioned in aphorisms no. 6 and 7 (Organon of Medicine, 6th edition of Master Hahnemann) for selection the similimum, the homoeopathic physician forms a portrait of the patient after taking the history and framing “Totality of the Symptoms” with an organized placement of all the subjective and objective symptoms. The prevalence of Osteoarthritis in India is 22% to 39%. It’s a second most common Rheumatological problem facing by population with frequent joint pain, limitation in joint movement which disturbs day to day life. It was estimated as 10 th leading cause of non-fatal burden. Osteoarthritis of knee joint cause mobility impairments commonly found in aged and obese female. After Diabetes and Hypertension Osteoarthritis of the knee is a very common disease these days. Homoeopathic medicines have minute materialistic drug substance in to the potentised form and so it’s safe, and...
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