Posted by admin on Aug 31, 2024 in |
Dineśavallīor Vēṁpātais a very popular Ᾱyurvēda herb used in South India for skin related ailments. In Kerala it is used in different formulations either as single drug or in combinations. There are no direct references to dineśavallī or Vēṁpāta in any bŗhatrayī or laghutrayī. From the previous studies it is confirmed that dineśavalli of south India is equated with ‘Ratanjot’– a herbal dye of North India and from the literature review, roots of Arnebia and Alkanna which is sold as ‘Ratanjot’. Dineshavalli (Vēṁpāta) is assumed to be sourced from Ventilago madraspatana Gaertn. belonging to Rhamnaceae family. But some allied species such as Ventilago bombaiensis Dalzell. and Ventilago denticulata Willd. are also termed as Vēṁpāta locally. Present study reviews the major classical texts of Ayurveda and peer reviewed articles to reveal the botanical identity, chemical constituents, pharmacological properties and its therapeutic efficacy of Dineśavallī or Vēṁpāta for the better...
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Posted by admin on Aug 31, 2024 in |
Metabolic syndrome is the most widely and prevailing health concern globally. It is a cluster of biochemical and physiological abnormalities that involve obesity, insulin resistance, dyslipidemia, and hypertension. Several studies have reported that the prevalence of the overall metabolic syndrome rate in adults is about 25% (approx. 31% in women and 18.5% in men) in India. Whereas the global prevalence is about 20-25% in 2020. The direct relationship between diet and health leads to various scientific studies to find the significant relation and their specific beneficial functions. Certain foods are thought to have physiological effects in the management of metabolic syndrome by assisting the body’s hemostasis mechanism. The present paper reviews different features of nutraceuticals and functional foods and their influence on the management of metabolic syndrome. Also, it overviews numerous functional ingredients in different food sources and their possible health...
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Posted by admin on Aug 31, 2024 in |
Osteoarthritis in the hip creates a major cause of pain and functional limitation. Acupuncture is an effective treatment for reducing inflammation and protecting muscles and produce pain control associated with disorder. Acupuncture is a proven, comprehensive method that helps to restore normal body function. The aim of this study is to find out the effect of acupuncture for relieving chronic hip pain. Here we report a 45-year-old female presenting with swelling, redness and pain on the right hip and with left hip congenital dislocation and eventually diagnosed as right hip osteoarthritis. X-ray showed superior congenital dislocation of left hip. The patient was treated with the selected acupoints ST44, ST36, UB 32, UB 35, UB 40, GB 32, LI4, LI11, DU20, P6, UB60, UB11, and GB34 for half an hour in alternate day for one week and then 15 days once followed for 6 months. VAS was used to measure pain. After treatment, the patient showed improvement in pain and functional ability. The patient is under regular check...
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Posted by admin on Aug 31, 2024 in |
The primary cause of death for women with gynaecological cancer diagnoses is ovarian cancer. It is also, generally speaking, the sixth most common cause of death for women. The majority of cases had advanced diagnoses, which worsens the disease’s prognosis. The limited predictive value of the current screening tests adds even more suffering to the situation. The most important early detection techniques, which have not had a discernible positive impact on the morbidity or death of this malignancy, are comprehensive gynaecological evaluation, transvaginal ultrasonography, and laboratory markers such as the cancer antigen-125 (CA-125) assay. However, anti-angiogenic bevacizumab and Poly (ADP-ribose) polymerase (PARP) inhibitors have gained pace in the management of this condition. Traditionally, the treatment regimen involves surgery and platinum-based chemotherapy. Although the exact etiology of ovarian cancer is unknown, there are several factors that have been found to raise the risk of the illness. Experts understand that DNA alterations, or mutations, occur in ovarian cancer-causing cells when they originate within or close to the ovaries. The instructions that...
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Posted by admin on Aug 31, 2024 in |
Cytochrome P450 2D6 (CYP2D6) is an essential enzyme that affects the safety and effectiveness of a broad range of medications through its metabolism. We provide here an extensive in-silico investigation of new drug candidates that target CYP2D6. To find putative CYP2D6 inhibitors, we used virtual screening, structure-based drug design, molecular docking, and simulation approaches in the Biovia Discovery Studio 2022 framework. By maintaining ADMET and TOPKAT filters, a broad variety of small molecules were subjected to virtual screening. After that, the two chosen compounds, cmp1 and cmp13, were used in molecular docking studies against the 4WNU and 4XRZ proteins to evaluate binding affinities and interactions. For 2815 compounds, ADMET and TOPKAT profiling were done to get non-toxic molecules. The non-toxic molecules after filtrations were taken for the docking studies followed by molecular dynamic simulation of the best complex. The best two molecules after ADMET and TOPKAT profiling were taken for docking studies, where these results demonstrated several intriguing therapeutic options with high binding affinities and favorable interactions of compound cmp1...
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