Posted by admin on Aug 31, 2024 in |
Oyster mushrooms are considered functional foods due to their structure. Our work focused on assessing the antioxidant power and determining the secondary metabolite content of mushroom teas formulated from the best-known, cultivated and eaten species. We carried out an ethnonutritional survey, and the species selected were used for the rest. We implemented a mixing plan after which 13 formulations were selected to prepare the various herbal teas. Pleurotus pulmonarius, Pleurotus ostreatus and Pleurotus floridanus were the most cultivated, known, and consumed species. DPPH test revealed that T5, T6 and T2 exhibited the best CI50: 17.39 ± 0.35b, 17.65 ± 1.20b, and 18.93 ± 0.31bc respectively compared to the standard which had a CI50 of: 3.09 ± 1.56a. In the FRAP test, T3, T9 and T11 displayed the best IC50 values: 7.72 ± 2.51b, 10.16 ± 0.14c, 11.00 ± 0.17cd, respectively, while the standard had an IC50 of 1.80 ± 1.06a. In the hydrogen peroxide test, T1, T3 and T4 had the best CI50 values: 23.44 ± 2.94b, 24.98 ±...
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Posted by admin on Aug 31, 2024 in |
Methotrexate (Mtx) is used to treat a number of conditions, including certain types of malignancy. Therefore, the purpose of this study was to investigate the potential protective impact of flavonoid quercetin on toxicity caused by methotrexate using hematological, biochemical, histopathological and oxidative stress approaches. There were four different groups, each group consisting of ten rats. The group 1 was a control, and animals were treated with 0.5 ml of carboxymethyl cellulose. Group 2 and 3 were treated with methotrexate (0.250 mg/kg); quercetin (50 mg/kg) and group 4 were treated with methotrexate (0.250 mg/kg) + quercetin (50 mg/kg). All drugs were given orally via oral gavage once daily for 28 days. At end of the trial, blood samples were collected from all of the animals for hematological, biochemical and oxidative stress parameters estimation. Following the animal’s sacrifice, organs were collected for histopathological examination. The levels of TP, ALB, renal indicators like BUN and creatinine and liver enzymes like AST, ALT, and ALP were markedly elevated by methotrexate at dose rate...
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Posted by admin on Aug 31, 2024 in |
Artificial Intelligence (AI) focuses on producing intelligent modelling, which helps in imagining knowledge, cracking problems and decision-making. Recently, AI played an important role in various fields of pharmacy like drug discovery, drug delivery formulation development, poly-pharmacology, hospital pharmacy, etc. In drug discovery and drug delivery formulation development, various Artificial Neural Networks (ANNs) like Deep Neural Networks (DNNs) or Recurrent Neural Networks (RNNs) are being employed. Several implementations of drug discovery have currently been analysed and supported the power of the technology in quantitative structure-property relationship (QSPR) or quantitative structure-activity relationship (QSAR). In addition, de novo design promotes the invention of significantly newer drug molecules with regard to desired/optimal qualities. In the current review article, the uses of AI in pharmacy, especially in drug discovery, drug delivery formulation development, poly-pharmacology and hospital pharmacy are...
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Posted by admin on Aug 31, 2024 in |
The objective of this research was to design and validate an alternative accurate method for quantitative determination of Amphotericin B. Amphotericin B deoxycholate life-saving drug belongs to the polyene class approved for the treatment of progressive and potentially fatal fungal infections. Amphotericin B was estimated at 382 nm and the percentage recovery was found to be 100.2 ± 0.34. The method was tested and validated for various parameters according to the ICH guidelines. The repeatability (inter-day) and intermediate precision (intra-day) precision studies revealed that the method is precise and reliable where all the RSD values were less than 2% for the routine analysis of drug. The limit of detection and limit of quantitation were 0.5μg/ml and 1.5μg/ml respectively. Results shows that the developed method is simple, reproducible and successfully for the estimation of Amphotericin B without the interference of common...
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Posted by admin on Aug 31, 2023 in |
Thrombosis is one of the major causes of death and disability worldwide. Cancer patients are commonly thrombophilia or prothrombotic since they have abnormalities in all three factors of Virchow’s triad, which lead to thromboembolism. Venous thrombosis (VT) is a chronic disorder that has the potential to be fatal and cause considerable complications. Venous thromboembolism (VTE) may potentially be the first indication of an undetected cancer in individuals. The rate of VTE and the risk of complications are much higher in the cancer patient groups. Arterial thrombosis is more likely to form when the plaque on the wall of the arteries consists a significant quantity of lipids covered by a layer of connective tissue. Thrombus formation in arteries may result in a heart attack or stroke. The hemostasis phase (liquid blood quickly hardens and forms a clot following injury to the blood vessel wall) spirals out of control. As a result, many blood clots form in the blood vessels that provide blood to various organs. Patients display paradoxically both excessive...
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