Posted by admin on Aug 31, 2023 in |
Plants have been widely adopted as the source of all drugs; this field has gradually broadened in developing countries where traditional medicine is essential in health care. Flaxseed is the seed from the plant Linum usitatissimum, which is an annual plant. This plant has attracted man’s attention for its advantages for human health. Plant materials contain a lot of bioactive phenolics, which demonstrate biological activity, including anti-radical, antioxidant, anti-microbial, and anti-cancer effects. Antioxidants are synthetic or natural compounds that can delay some types of cell damage and quench reactive radical species formed during oxidative reactions in metabolism. Our aim is to collect the seed of Linum usitatissimum L., screen the antibacterial activity of the solvent extracts of this plant against some selected bacteria, and identify the bioactive chemical compounds from the plant extracts using preliminary phytochemical analysis. To investigate the antioxidant activity of methanol, ethyl acetate, and chloroform extracts of Linum usitatissimum...
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Posted by admin on Aug 31, 2023 in |
Objective: The study aims to evaluate the granuloma and associated inflammatory mediators inhibition potential of the chloroform extract of Piper pedicellatum C. DC. Leaves, as plant leaves, are being used traditionally in the mitigation of various inflammatory conditions; however, there is an insufficiency of scientific evidence about the relevant bioactivity of the plant. Method: The cotton pellet induced-granuloma model in rats is used in the study, providing insights into subsequent phases of inflammation. Piper pedicellatum C. DC. Leaf chloroform extract at 200 mg/kg and 400 mg/kg and indomethacin (reference standard, 10 mg/kg) were used during treatment. Results: The chloroform extract at 200 mg/kg and 400 mg/kg dose inhibited exudate formation by 25.23% and 38.43%, respectively, and inhibition of granuloma tissue was found to be 27.62% and 40.33%, respectively. Further significant decrease in serum inflammatory markers CRP and PGE2 and reduced cytokine TNF-α and IL-6 were observed in chloroform extract and indomethacin-treated rats. In contrast, a substantial increase in anti-inflammatory cytokine serum IL-10 levels was noted in treated rats. Conclusion:...
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Posted by admin on Aug 31, 2023 in |
An overview of the neurodevelopmental disorder ADHD (attention deficit hyperactivity disorder), its consequences, and details on the brain regions impacted by ADHD are the driving forces behind this review. The hereditary basis of ADHD has been investigated. Throughout the investigation, numerous reviews and research publications were compared and examined. The themes covered in this article are (a) ADHD as well as its symptoms (b) the complexity of the brain regions affected in ADHD patients (c) and (d) linkage analysis for researching the genes of ADHD. The brain’s structure, development, and functioning will alter, according to review analysis results. The main brain areas involved include the cerebellum, parietal, Prefrontal and frontal lobes. According to the study, the thickness of the cerebellum will diminish, and the anterior striatal region will be most negatively impacted. There isn’t much proof that ADHD is inherited, although a few experts have suggested that there may be a connection between siblings’ ADHD and their DNA. For a complete understanding of the condition, a great deal more...
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Posted by admin on Aug 31, 2023 in |
Rosuvastatin is a widely used lipid-lowering medication that belongs to the class of “Statins” whereas Teneligiptin is a novel potent drug that belongs to the class of “DPP-4 inhibitors” which is used for the treatment of Type 2 Diabetes mellitus. The FDA recently approved the combination of these two drugs in 2021 since it proved to be highly effective for treating dyslipidemia associated with Type 2 Diabetes mellitus. Forced degradation studies have been performed on Rosuvastatin and Teneligliptin separately using various analytical techniques such as RP-HPLC, UV, RP-UFLC, RP-UPLC, UHPLC, HPTLC and TLC. Characterization of the degradation products generated during various stress conditions is also performed using various sophisticated techniques such as UPLC, LC/MS/MS, NMR, and FT-IR. These degradants can cause many adverse effects, such as carcinogenicity, mutagenicity, neurotoxicity, hepatotoxicity, skin sensitization, respiratory sensitization, etc. So, identifying and characterizing these degradation products will be very useful for their metabolic studies and in-silico toxicity assessment. In-silico toxicity studies are very helpful in predicting the toxic potential of these degradants, and...
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Posted by admin on Aug 31, 2023 in |
Tuberculosis (TB) is caused by a bacterium called Mycobacterium tuberculosis, identified as a global health emergency by the world health organization. The development of drug-resistance stains due to spontaneous gene mutation has been a major boost to research in the pathogenicity and biochemistry of Mtb. To combat drug resistance to tuberculosis, new drugs and methodologies are emerging. Since, starting itself mycobacterium complex cell wall has been a choice for widely selected targets for anti-TB drugs. Peptidoglycan, arabinogalactan, and mycolic acid are the basic layers supporting cell growth. The current work investigates virtual screening for optimal small molecule inhibitors targeted against selected mycolic acid targets (β-keto acyl ACP synthase, enoyl acyl ACP-reductase and Polyketide synthase 13). A small library of 485 compounds was designed and docked into a selected target core to identify the potential inhibitor. The designed compounds were subjected to docking studies using Glide (Schrodinger). InhA was the most suitable mycolic acid inhibitor target for the designed compounds. Further, the effectiveness of the study was evaluated by comparing the...
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