Posted by admin on Aug 31, 2021 in |
A simple, reliable, accurate and precise method was developed for the simultaneous estimation of Fexofenadine and Montelukast in pharmaceutical dosage form. The chromatogram was run through Standard HSS C18 (2.1 × 100 mm, 1.8 µm). Mobile phase employed was 0.1% OPA Buffer and Acetonitrile taken in the ratio of 65:35 was pumped through column at a flow rate of 0.2 ml/min. The temperature was maintained at 30 °C. The optimized wavelength selected was 269 nm. The retention time of Montelukast and Fexofenadine was found to be 0.921 and 1.101 min. The Percent RSD of the Montelukast and Fexofenadine were and found to be 0.7% and 0.4% respectively. The Percent recovery was obtained as 99.22% and 99.67% for Montelukast and Fexofenadine respectively. The LOD and LOQ values obtained from regression equations of Montelukast and Fexofenadine were 0.06, 0.18 and 0.80, 2.44 respectively. Regression equation of Montelukast was y = 6333.8x + 755.96 and y = 4038.3x + 8964.8 of Fexofenadine. The decrease in the retention and run times in this...
Read More
Posted by admin on Aug 31, 2021 in |
Herbal medicine is the source of primary health care due to its cultural acceptability and better compatibility with the human body and lesser side effects. Resha-e-Makka (Zea mays) is an important medicinal plant in the Unani system of medicine (USM) due to its multiple therapeutic properties. The review has been reviewed, compiled, and analyzed using references from major databases like classical text and indexed journals. The plant is known to treat different systemic ailments due to the presence of Saponins 3%, Alkaloid, Bitter glycoside, Stearic acids, Tannins, Amine 0.05% etc. In USM, the pharmacological actions of Resha-e-Makka are anti-inflammatory, diuretic, Lithtontroptic, astringent, muhallil Balgham, etc. Zea mays is reported for its antibacterial, anti microbial, anti-deperssant, anti-diabetic, hypolipidemic, antioxidant, hepatoprotective, antimalarial, antipyretic, analgesic, anti-inflammatory, anti-cancer, etc. activity. The review explores the pharmacological, phytochemical, and therapeutic properties of Zea mays Lin. Many pharmacological activities mentioned in Unani medicine are validated and many activities need further exploration due to the immense therapeutic scope in this...
Read More
Posted by admin on Aug 31, 2021 in |
The objective behind this study is to investigate the affinity between a carboxylic model drug telmisartan and kaolin. Telmisartan was comilled in solid state with kaolin in different weight ratios and characterized by Fourier transform infrared spectroscopy, Differential scanning calorimetry, X-ray powder diffractometry, scanning electron microscopy to examine the extent of transformation from crystalline to amorphous state. XRD and SEM studies revealed complete amorphization of telmisartan on comilling with kaolin for 1 h at 1:2 ratio. FTIR study showed that on milling with kaolin, the free acid carbonyl peak of telmisartan at 1692.14 cm-1 was disappeared, and a new carboxylate peak at 1578.72 cm-1 appeared. This disappearance of acid carbonyl peak and appearance of new carboxylate peak indicating an acid-base reaction between the carboxylic acid of telmisartan and kaolin. DSC study stated that in the milled samples, the melting endotherm of telmisartan was gradually shifted to lower temperature, and the intensity, as well as sharpness of the endotherm, was decreased. In-vitro study showed greater dissolution of telmisartan from telmisartan-kaolin...
Read More
Posted by admin on Aug 31, 2021 in |
Poor aqueous solubility has been one of the major challenges in modern drug delivery as it hinders the absorption process leading in the decrease of bioavailability. As a consequence of low water solubility of drugs, low oral bioavailability is a growing challenge to the development of new pharmaceutical products. There has been a consistent increase in the number of new pharmacologically active lipophilic compounds that are poorly water-soluble. Approximately 40% of new drug candidates are lipophilic and exhibit poor water solubility. One of the popular approaches of oral bioavailability and solubility enhancement is the utilization of lipid-based drug delivery systems – self microemulsifying drug delivery system (SMEDDS). Self-micro emulsifying drug delivery system (SMEDDS) is one of the exclusive approaches to increase bioavailability by improving solubility for the poorly aqueous soluble drug and to increase the oral absorption of highly lipophilic drugs. These systems have unique property to form oil in water emulsion under gentle agitation provided by digestive motility of the stomach and intestine. A greatest advantages of incorporating...
Read More
Posted by admin on Aug 31, 2021 in |
Areca catechu L. (Arecaceae) is a species of palm mainly grown in Asian countries for seed crop. Areca nut leaves are commonly used in traditional systems of medicine against various ailments. There is a need for identifying native natural plant sources to acquire their recognized medicinal properties, which may widen them to use as new therapeutics for various diseases. Phytochemical investigation of the leaves of Areca catechu L. yielded a alkaloid- Arecoline, from the chloroform extract; a flavonoid- Apigenin, from the methanol extract and a steroid- Stigmasterol, from petroleum ether extract. In-vitro methods were used to evaluate the pharmacological activity of the leaves of Areca catechu L. Anti-inflammatory activity of the leaves of Areca catechu was estimated by using standard methods like protein denaturation method using bovine serum albumin fraction and egg albumin and by HRBC membrane stabilization method. The result suggests that the leaves possess good antioxidant as well as anti-inflammatory...
Read More
