Posted by admin on Sep 1, 2011 in |
Cassia tora Linn. (Family: Leguminosae) is well known plant widely distributed in India and other tropical countries. It is an annual under shrub and grows in wild wasteland. Different parts of the plant (Leaves, seed, and root) are reputed for their medicinal value. It is well recognized traditional medicine as laxative and is useful for treatment of leprosy, ringworm infection, ophthalmic, skin diseases and liver disorders. Several chemical compounds such as Anthraquinone glycosides, Naphthopyrone glycosides, Phenolic compounds, Flavonoids etc. have been isolated from this plant. The present review summarizes the scientific information of various aspects of Cassia tora plant used in traditional system of medicine for variety of...
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Posted by admin on Sep 1, 2011 in |
β- Thalassemia is an inherited genetic disorder which is caused by different kinds of mutations in the HBB gene in chromosome 11. Due to several types of mutation in β- gene, globin chains cannot synthesise completely and free α-globin is highly unstable and readily precipitates bound heme and iron. In β- thalassemia these precipitated iron, repeated blood transfusion and increased gastrointestinal iron absorption lead to iron overload in the body. The increased free iron in blood is responsible for the formation of Reactive Oxygen Species (ROS). If the production of ROS exceeds the capacity of enzymatic and non-enzymatic antioxidants systems to scavenge these species or if these protective systems are compromised, then oxidative stress occurs. This review summarizes the production of ROS, its effect and different drug and plant extract used as an antioxidant as well as chelating agent in thalassemic...
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Posted by admin on Sep 1, 2011 in |
Chitosan is a cationic natural polysaccharide which is derived from the chitin of crustaceans, with crabs and shrimp-shell wastes as its principal source. Its properties includes extent of deacetylation and the average molecular weight of polymer as well as low toxicity and good bioavailability make it a novel excipient in pharmaceutical formulation as a relatively new development. Together with chitin, chitosan is well thought-out the second most abundant polysaccharide subsequent to cellulose. But in contrast to cellulose, the application of Chitosan in pharmaceutical field is a pretty new development. Recently there are so many formulation were prepared and evaluated within different dosage forms such as ophthalmic, nasal sublingual, buccal, periodontal, gastrointestinal, colon specific, vaginal, transdermal as well as gene carrier which is based on the application of chitosan and its derivatives. Chitosan is biocompatible and show the activities such as antimicrobial and antifungal activities, which makes it a favourable option for biomedical applications. It has been proven to be useful in tissue growth, in tissue repair and accelerating wound-healing...
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Posted by admin on Sep 1, 2011 in |
Analytical methods employed for the determination of drugs and metabolites in biological matrices such as urine, plasma and serum are essential throughout drug discovery and development. It is well-known that, analytical techniques are constantly undergoing change and improvements and each analytical method has its own characteristics which may vary from analyte to analyte at different conditions. As the drug continues through development, the decisions become more critical; therefore, the bio-analytical methods that produce the data should be accurate. In the present study, we have developed a simple, precise and reproducible liquid chromatography tandem mass spectrometry method and validated according to FDA-GLP guidelines for quantification of Omeprazole in human plasma using Lansoprazole as internal standard utilizing LC-MS/MS incorporated with quadrapole mass spectrometer utilizing electrospray ionization technique. Samples were analyzed for Accuracy, Precision, Sensitivity, Selectivity, Recovery, stability and accuracy of method by injecting spiked matrix (human plasma) in to LC-MS/MS. The method specificity was determined by analyzing six different batches of human plasma to check the chromatographic conditions from endogenous plasma...
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Posted by admin on Sep 1, 2011 in |
Ethosomal systems are now a days attracting attention of many researchers. This study is designed to observe the effect of penetration enhancers in ethosomal formulations. Ascorbic acid is taken as a model drug; phosphatidylcholine and ethanol are taken for ethosome preparation. Propylene glycol is taken as a penetration enhancer. Ethosomes are prepared by solvent dispersion method with and without penetration enhancer. The drug release profile is compared. Dialysis membrane and human cadaver skin are taken for penetration study. In this study the ethosomes which were prepared by adding penetration enhancers showed better penetration...
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