Posted by admin on Aug 31, 2018 in |
Introduction: Antiplatelets play a crucial role in improving many metabolic disorders and complications, including dyslipidemia, atherosclerosis, diabetes mellitus and cardiovascular diseases. The most common and effective antiplatelets used widely are aspirin and clopidogrel. The aim of this study is to evaluate the dyslipidemic and protective effects of aspirin and clopidogrel in obese rats. Materials and methods: 24 rats were divided into two groups, control (n = 6) (was taken normal chow) and the other group (n = 18) were allowed to eat beef tallow (90 g) and saturated fat (10 g) for 6 weeks to induce obesity. The second group was further classified to three subgroups, subgroup I (n = 6) was kept as obese group (n = 6) (positive control), subgroup II (n = 6) obese rats were treated with aspirin and subgroup III (n = 6) obese rats were treated with clopidogrel for 7 days. At the end of experiment blood samples were taken and lipid profile, FBS measured as well as body weight and the relative...
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Posted by admin on Aug 31, 2018 in |
The purpose of the present study was to synthesize and evaluate the potential of folate-G.4.0-PAMAM dendrimer conjugates as acceptable vehicle for site specific delivery of piroxicam (PXM) to inflammatory regions and to determine its targeting efficiency in carreganan induced arthritic rats. PXM was selected as a model acidic anti inflammatory drug. Folic acid was linked to the surface amino groups of G4.0-PAMAM dendrimer through a carbodiimide reaction and loaded with PXM. The coupled conjugates were characterized by 1H-NMR, IR spectroscopy and polyacrylamide gel electrophoresis (PAGE). The drug content and % encapsulation efficiency increased with increasing folate content for the dendrimer conjugates. The in- vitro release rate was decreased for the PXM-F1, PXM-F2 and PXM-F3 conjugates when compared with PXM-D1. Drug dendrimer and conjugates were further evaluated for haemolytic toxicity and stability study. There was no change in turbidity, colour, consistency in stability study. Efficacy of plain PXM and dendrimer conjugates was tested by carrageenan induced paw edema model. Pharmacodynamic study revealed 74%, 78%, 85%, 90% inhibition at 4th hour...
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Posted by admin on Aug 31, 2018 in |
In order to effectively manage the diabetic mellitus type-II hyperglycemic surge, bilayered tablets comprising of gliclazide in immediate release layer (IRL) and metformin in sustained release layer (SRL) have been designed and fabricated for years. Gliclazide suffers from reduced aqueous solubility of 0.19 mg/mL which remained a crucial problem for the biological effect as a result of reduced dissolution and bioavailability. Therefore, in this research an effort was done to improve the aqueous solubility of gliclazide in a bilayer tablet by forming solid dispersions which will provide prompt release to completely manage the postprandial effectually. In this study, a bilayer tablet of gliclazide solid dispersion in IRL and metformin in SRL were fabricated by direct compression method, with an intention that the IRL of the formulation will release the gliclazide at its earliest to combat the postprandial hyperglycemic level followed by a control of steady state plasma glucose by sustained release metformin. The compatibility studies, pre-compression studies, post-compression studies, disintegration studies, dissolution studies, and kinetic release studies were performed....
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Posted by admin on Aug 31, 2018 in |
Aims and Objectives: To evaluate the current prescription pattern of drug utilization in patients admitted in cardiology intensive care unit (ICU) and to find out drug use indicators. Methods: It was a retrospective, observational hospital based study which was done for 6 months after obtaining permission from the institutional human ethics committee. The prescriptions of both genders and of any age groups suffering from any cardiovascular indication who were admitted in cardiology ICU were included. The parameters assessed were demographic profile of the patient, most common diagnosis, ICU outcome, number of days of ICU stay, most common group and number of drugs/prescription. Results: Data from 280 prescriptions were analyzed and it was found that 41-60 yrs patients were most commonly affected (53.6%), coronary artery disease (71.4%) is the most common indication. Most of the patients were discharged in improved condition (82.10%) with an average length of stay >5 days. Nitroglycerin (75.6%) is the most common drug used and at an average >12 drugs are used. Conclusion: Prescribing guideline is...
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Posted by admin on Aug 31, 2018 in |
Anxiety affects a large number of the population that creates an economic burden. Various traditional medicines like barbiturates, benzodiazepines and SSRI’s are used as anxiolytics but due to their potential to produce adverse effect on cognition limits their chronic use. Several homeopathic remedies are used for treating anxiety. For the first time this study was designed to determine anxiolytic activity of 30C Argentum nitricum. The remedy was compared with escitalopram. For this purpose several behavioral parameters were analyzed using head dip test, home cage activity, open field test and light and dark test. Distilled water, Argentum nitricum and escitalopram were administered orally to three groups of animals. The effects were recorded after 30th and 60th days of dosing. The results were compared statistically using one way ANOVA and Tuckey test was also being done for the multiple comparisons. The remedy highly significantly decreased the head dips and cage crossings after the 60th day of dosing (p ≤ 0.001). The central squares crossings in the open field apparatus was increased...
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