Posted by admin on Aug 31, 2016 in |
Background: Venous thromboembolism (VTE) is a common complication during and after hospitalization for medical patients. Previous studies have shown that only about one third of high risk medical patients receives VTE prophylaxis. Guidelines such as the one produced by the American college of Chest Physicians (ACCP) are aimed at reducing hospital associated VTE. The objective of this study was to determine the appropriateness of VTE prophylaxis in medical inpatients at a large teaching hospital. Methods: In a prospective cross-sectional study, VTE prophylaxis were evaluated and the data were recorded during October 2014 to March 2015 in medical wards of “Alzahra” hospital, Isfahan, Iran. A caprini score, a VTE risk factor assessment tool was calculated for each patient based on data collected. Appropriate prophylaxis was determined after examining data, caprini score and prophylaxis regimen according to the ACCP 9th edition guideline. Results: A total of 100 patients met the inclusion criteria and were reviewed. According to the risk stratification, 18 patients classified as low risk, 30 as moderate and 47...
Read More
Posted by admin on Aug 31, 2016 in |
Simple, specific, accurate and cost economic UV spectrophotometric methods were developed and validated for determination of Celiprolol Hydrochloride. Instead of using organic solvents, mixture of dilute hydrochloric acid and water was used during method development and validation. The drug was extracted from tablet formulation with a mixture of water and hydrochloric acid. Stability of drug solution and formulation was established throughout the analysis time. Zero Order Derivative and Area Under Curve methods were developed for estimation of drug and both the methods were validated as per ICH guidelines. The linearity of drug was established by performing calibration curve. The analytical range of drug was established from linearity study. Precision of the method was established with Intraday and interday analysis. Accuracy was established by conducting recovery study. Robustness of both the methods was confirmed by conducting analysis with different...
Read More
Posted by admin on Aug 31, 2016 in |
This project involves in the development of sustained release matrix tablets of Gemigliptin. Which is an oral anti-hyperglycemic agent designed for the management of non insulin dependent diabetes mellitus (NIDDM). The basic goal of therapy is to achieve a steady sate blood level that is therapeutically effective and non toxic for an extended period of time. The objective in dosage form design is to optimise the delivery of medication to achieve the control of therapeutic effect in the face of uncertain fluctuation in the in-vivo environment in which drug release takes place. Eight formulations of Gemigliptin 50mg were formulated by admixing with HPMC K4M, Carbopol were used as rate controlling polymers in different concentrations, Micro crystalline cellulose, Lactose, Talc, Magnesium stearate. Pre-formulation and post-formulation studies were carried out and the values obtained, satisfies the pharmacopoeial specifications. Several kinetic models were applied to the dissolution profiles to determine the drug release kinetics. Of all the formulations F5 exhibited gradual and completion extended release for Gemigliptin. The F5 (carbopol) with 1:1...
Read More
Posted by admin on Aug 31, 2016 in |
The purpose of present study was to design and evaluate matrix tablets of Matrix tablets of Diltiazem hydrochloride were prepared by using natural polymers like Gum karaya and Gum kondagogu. The pre formulation study was performed on combination of drug with polymers by FTIR suggested that drug and polymers were compatable. The matrix tablets were prepared by using by wet granulation method. All the prepared tablets were evaluated for weight variation, hardness, friability, drug content uniformity and in vitro drug release characteristics. The formulation F4 shows the 99.75% of drug release up to 12 h when compared with all other formulations. Formulation containing diltiazem hydrochloride with gum karaya shows best and maximum drug release of 99.75% up to...
Read More
Posted by admin on Aug 31, 2016 in |
In some disease like thalassemia major long-term transfusion alone inexorably produces the clinical problem of iron overload. Danshen and Milk thistle has been widely prescribed in traditional folk medicine for treatment of liver diseases. In this study we selected eight medicinal plants whose efficiencies had been previously demonstrated in treatment of liver diseases in ancient medicine were studied for their in vitro chelating activity. After preliminary evaluation of these plants in vitro condition, two most efficient plants were nominated for further evaluation in in vivo condition on iron-overloaded mice. The extracts with high iron chelation activity were injected intraperitoneally. Liver sections were stained by haematoxylin and eosin and Perls’ stain. Danshen and Milk thistle had maximum iron chelation activity at in vitro condition. The iron-overloaded mice treated with the extracts showed a significant decrease in plasma iron level and in plasma Fe3+ content. Perl̕ stain improved sensitivity of the test significantly in order to determine the low amount of deposited iron in the liver of iron- overloaded mice treated...
Read More
