Posted by admin on Aug 31, 2017 in |
Chenopodium album (sub sp. striatum) is a folk and nutritious medicine belongs to Chenopodiaceae family and widely used as antimicrobial agent. The aim of this study is to evaluate the in vitro antibacterial potential against multidrug-resistance (MDR) bacteria isolated from clinical spicemens, antioxidant activity, total phenolic and total flavonoids content of crude ethanolic extract and nine different fractions of C. album (sub sp. striatum). The in vitro antibacterial activity was evaluate against eight multidrug-resistant bacteria based on minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC), agar well and disk diffusion methods. Antioxidant property was evaluated by 1, 1-diphenyl-2-picryl-hydrazyl radical scavenging activity. The total phenol contents were measured by Folin-Ciocalteu and AlCl3 assays. Our results showed that MeOH: H2O with 80:20 ratio (most polar) fraction had the highest antimicrobial effect on eight multidrug-resistant bacteria (MIC: 0.15-2.5 mg/ml, MBC: 0.31-5 mg/ml and had highest inhibitation zones (well: 24.33±0.57 mm and disk: 26.33±1.53 mm). In antioxidant assay, MeOH: H2O fraction also exhibited the highest radical scavenging activity [Antioxidant activity = 95.1±2.13...
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Posted by admin on Aug 31, 2017 in |
Background: The coronoid process of mandible is thin flat triangular process from the ramus of the mandible. This varies in the shapes and size. It gives attachment to two main muscles that is temporalis and masseter muscle. The coronoid process is the favourable donor site. A Coronoid process graft can be used for alveolar defects repair, orbital floor repair, maxillary augmentation, repair of non-union fracture of mandible. These grafts can be widely used in the reconstruction of osseous defects in oral and maxilla-facial region. Aim of the Study: This study is done to find out the variation in shape of coronoid process of mandible, Intercoronoid distance, coronoid- condylar distance and the length and breadth and thickness of the coronoid process of mandible. Methods: The study was done on the 100 dry human mandibles from the osteology bank of Saveetha medical college and hospital. The distance was measured using the digital vernier callipers and the values were analysed. Results: This study is useful for the maxillofacial surgeon and this useful...
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Posted by admin on Aug 31, 2017 in |
Periodontal dressings were widely used after flap surgery to protect the surgical site since long. This study compared polyether urethane dimethacrylate resin based Barricaid dressing and non-eugenol based periodontal dressings in the perspective of pain, esthetics and patient acceptance using a randomized split-mouth study design. Fifteen patients coming to the Department of Periodontics at ITS Dental College and diagnosed as a case of generalized chronic periodontitis were selected. Total 30sites (2 sites in each patient) requiring the flap surgery were selected and contralateral sites in each patient were randomly allocated into two groups. At baseline plaque index, Modified gingival index were recorded. In group-1 non-eugenol dressing and in group-II light cured periodontal dressing were applied to secure the surgical sites after flap surgery. At day1,2 and 3 pain and discomort was assessed using Numeric Pain Rating Scale.(NPRS) After 7 days patients were recalled for removal of dressing, recording the indices and asked to fill a questionarrie regarding the patient acceptability. Collected data were subjected to statistical analysis and non-significant...
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Posted by admin on Aug 31, 2016 in |
Many antifungal drugs are used topically in order to treat fungal diseases. Among them Ketoconazole is used widely among these topical antifungal drugs for eradication of dandruff. Scalp with dandruff causes more hair fall than normal scalp and hair fall is treated by topical Minoxidil formulation. Aim of present work is to prepare a topical formulation containing both ketoconazole and minoxidil in order to treat dandruff and associated diffused alopecia simultaneously. Both the drugs are incorporated in emulgel at a particular step in order to prepare formulation. Emulgel i.e. emulsion in gel have been emerged out as one of the most beneficial topical drug delivery system as it contain both hydrophilic and lipophilic drugs with dual controlled release system i.e. emulsion and gel. Incorporation of emulsion in gel also increases the stability of emulsion. Emulgel was prepared by using carbopol 934 as gelling agent. The influence of concentration of gelling agent and emulsifying agent on the drug release from the prepared emulgel was investigated using a 2×22 factorial design....
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Posted by admin on Aug 31, 2016 in |
Flouroquinolones (FQ) used commonly for treatment of community and hospital-acquired infections, has been prefixed with multiple adverse effects. Amongst them the glycemic variability has been attention seeking. Drug induced dysglycemia can be acute or persistent and severe too. The present study is designed to evaluate and compare the actions of Levofloxacin vs. Norfloxacin in altering blood glucose levels in Alloxan induced diabetic albino rats. 30 albino rats with fasting blood sugar (FBS) in the range of 80-115 mg/dl were induced diabetes with intraperitoneal Alloxan (150mg/kg body wt). After 7 days of induction, the rats that developed a stable hyperglycemia with FBS≥250 mg/dl were selected for the study. Following administration of test and standard drug FBS levels were measured on days 0, 3, 7, 14 & 28 using glucometer. Statistically, values in all the groups were analyzed by using one-way analysis of variance (ANOVA), followed by independent T test for group comparisons. P values less than 5% (0.05) was considered as significant. Glycemic variation was found to be statistically significant...
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