Posted by admin on Oct 1, 2010 in |
The Western Ghats of Kerala is famous for its medicinal plant wealth and the tradition of indigenous system of therapy, specifically the Ayurveda. Dasapushpam constitute a group of ten potential herbs which are culturally and medicinally significant to the people of Kerala in India. They are a group of ten herbs with which the ladies decorate their hairs and dance the Thiruvathira Kali on the day of Thiruvathira in the Malayalam month of Dhanu. These plants are therapeutically very active for various diseases and ailments. Many of them are traditionally used from time immemorial. Some of them are scientifically validated for various bioactivities. Still there are lots of possibilities for potential pharmacological activities from these herbs, yet to be explored. This article would give an insight of these ten sacred plants and their properties to further popularise these...
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Posted by admin on Oct 1, 2010 in |
The objective of the project is to develop a comprehensive database of Nuclear Receptor (NR) Superfamily-Ligand. Nuclear Receptor Superfamily represents one of the most important families of drug targets in pharmaceutical development. Nuclear Receptor) Superfamily-Ligand is a novel public NR-related chemical genomic database that is primarily focused on the correlation of information between NRs and their ligands. It provides correlation data between NRs and their ligands, along with chemical information on ligands, as well as access information to the various web databases regarding NRs. These data are connected with each other in a relational database, allowing users in the field of NR-related drug discovery to easily retrieve such information from either biological or chemical starting points. NR Superfamily-ligand database includes structure similarity search functions for the NRs and for their ligands. Thus database can provide correlation maps linking the searched homologous NRs (or ligands) with their ligands; we can gain more detailed knowledge about their interactions and improve drug design efforts by focusing on inferred candidates for NR-specific drugs....
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Posted by admin on Oct 1, 2010 in |
Aseptic processing is a widely used technology in the field of pharmaceutical, biotech, and medical device industries for the preparation of sterile materials. The term aseptic processing as it is applied in the pharmaceutical industry refers to the assembly of sterilized components and product in a specialized clean environment. Aseptic processes are some of the most difficult processes to conduct in the pharmaceutical industry. Because of the nature of aseptic processes, sterile products produced aseptically present a significantly higher risk to the patient than terminally sterilized products. Because of the high level of risk, an effective quality risk management program is necessary to protect the patient. An effective risk-management program aids in the careful control of the process, reducing the risk of contamination as well as wasted effort in controlling insignificant...
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Posted by admin on Oct 1, 2010 in |
Over the past two decades, intranasal drug delivery has shown tremendous promise for systemic delivery of therapeutic agents, although the potential of the nose as a route of administration has been known since ancient time. Psychotropic and hallucinogenic agents have been used as snuff in many parts of the world for hundreds of years. Because of rich vasculature and highly permeable structure, nasal route could be used as an alternative to parenteral routes of delivery. Nasal route circumvents hepatic first pass metabolism and gut wall enzyme mediated degradation. Nasal route is easily accessible for self-administration without the help of health professionals, and no needle stick hazards are associated with nasal administration. Other advantages of nasal drug delivery systems include rapid onset of action, reduced risk of overdose and improved patient compliance. However, there are several disadvantages of nasal route of administration including impermeability of nasal mucosa to lipophillic and high molecular weight drugs, mucotoxicity associated with long term use of formulation, requirement of expensive delivery device, and dose...
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Posted by admin on Oct 1, 2010 in |
Eye is most unique organ of the body. Various drug delivery systems are used to deliver drug into eyes are used but there are various limitations of conventional systems so researchers are finding new ways by which contact time, bioavailability and residence time can be enhanced as well as patient discomfort and frequency of dose can be reduced. The conventional dosage forms are account for 90% of currently accessible ophthalmic formulations. The major problem encountered is rapid precorneal drug loss. To improve ocular drug bioavailability, there are significant efforts directed towards newer drug delivery systems for ophthalmic administration. Newer research in ophthalmic drug delivery systems is directed towards a combination of several drug delivery technologies, that includes to develop systems which is not only prolong the contact time of the vehicle at the ocular surface, but which at the same time slow down the elimination of the drug. In this review various new drug delivery systems applied in eye like inserts, in-situ gel, liposomes, niosomes, nanoparticles, iontophorosis, corneal shields,...
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