Posted by admin on Sep 1, 2010 in |
Gastric hyperacidity and gastro duodenal ulcer is a very common global problem today. Among various causes of gastric ulceration lesions caused by stress, alcohol consumption, H.pylori infection and use of NSAIDs have been shown to be mediated largely through the generation of reactive oxygen species (ROS), especially hydroxyl radical (*OH). Hyper secretion of gastric acid is a pathological condition, which occurs due to uncontrolled secretion of hydrochloric acid from the parietal cells of gastric mucosa through the proton pumping H+ K+ ATPase. The modern approach to control gastric ulcer is to inhibit gastric acid secretion, to promote gastro protection, to block apoptosis and stimulate epithelial cell-proliferation for effective healing. On contrary most of the green pharmaceuticals reduces the offensive factors and have proved to be safe, clinically effective, better patient tolerance, relatively less expensive and globally...
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Posted by admin on Sep 1, 2010 in |
Vitex negundo is an important medicinal plant with potent anti-inflammatory activity. The major constituents of this plant are flavonoids, casticin, chryso-splenol and vitexin, Chrysophenol D, nishindine and hydrocotylene. It also contains monoterpenes agnuside, eurostoside, and aucubin. These constituents contribute various pharmacological activities as anti-inflammatory, antioxidant, antinociceptive, anti-ulcer, free radicals scavenging, hepatoprotective and many more. This review discuss the investigation made by various workers related to its ethnobotanical claims, ayurvedic properties, chemical constituents, pharmacological activities ,analytical studies and other aspects considering this plant since years till date....
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Posted by admin on Sep 1, 2010 in |
Organisms containing integrated sequences of cloned DNA (transgenes), transferred using techniques of genetic engineering (to include those of gene transfer and gene substitution) are called transgenic animals. The development of transgenic animals has been part of biotechnology research which has been expanding rapidly. Transgenic animals produced with the purpose of producing better and good quality breed, increased in milk yield, as well as to produce organs to meet the demand for organ transplantation. Genetically modified animals are proving ever more vital in the development of new treatments and cures for many serious diseases. Transgenesis is a radically new technology for altering the characteristics of animals by introducing the foreign genetic material. Now a day’s numbers of methods are available to produce transgenic animals like Pronuclear micro-injection, Embryonic stem (ES) cell manipulation, Cre-lox technique, Viral vectors, Cytoplasmic injection, Primordial germ cells, Nuclear transfer and Spermatogonial manipulation among them Lentiviral vectors and Chimera generation by injecting the pluripotent cells methods are becoming important tools for transgenesis and they contributed to human...
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Posted by admin on Sep 1, 2010 in |
Most of the new chemical entities coming out from High-throughput screening in drug discovery process are failing due to their poor solubility in the water. Poorly water-soluble drugs show many problems in formulating them in conventional dosage forms. One of the critical problems associated with poorly soluble drugs is too low bioavailability. The problem is even more complex for drugs belonging to BCS CLASS II category, as they are poorly soluble in both aqueous and organic media, and for those drugs having a log P value of 2. There are number of formulation approaches to resolve the problems of low solubility and low bioavailability. These techniques for solubility enhancement have some limitations and hence have limited utility in solubility enhancement. Nanotechnology can be used to resolve the problems associated with these conventional approaches for solubility and bioavailability enhancement. Nanotechnology is defined as the science and engineering carried out in the nanoscale that is 10-9 meters. The present article describes the details about nanosuspensions. Nanosuspensions consist of the pure poorly...
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Posted by admin on Aug 15, 2010 in |
Oral Disintegrating Drug Delivery Systems (ODDDS) have the unique property of rapidly disintegrating and/or dissolving and releasing the drug as soon as they come in contact with saliva, thus obviating the requirement of water during administration. Methods to improve patient’s compliance have always attracted scientists towards the development of fancy oral drug delivery systems. Among them, oral disintegrating drug delivery systems (ODDDS) have acquired an important position in the market by overcoming previously encountered administration problems and contributing to extension of patient life, which includes dysphagic, bed ridden, psychic, geriatric and pediatric patients. This review describes the various technologies developed for ODTs, different patented technologies and their products, disintegrated employed and their mechanism of action, taste masking methods and evaluation...
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