Posted by admin on Aug 1, 2010 in |
Six generic ciprofloxacin HCl 250 mg tablets from different manufacturer have been evaluated to assess their bioequivalence using in vitro tests. Other general quality assessments of these tablets like assay, weight variation, hardness, friability, disintegration time were also determined and all these generic tablets passed compendial specifications. There were no significant differences (p < 0.05) in the percentage dissolution of drug from generic tablets at 15 minutes with the same from innovator brand tablet at the same time point. To compare the dissolution profiles of all the tablet formulations and the innovator brand, a model independent approach of difference factor (f1) and similarity factor (f2) was employed with all time points included in the in vitro dissolution studies. These results indicated that all generic ciprofloxacin HCl tablets included in this investigation were bioequivalent with the chosen innovator brand and so may be used interchangeably....
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Posted by admin on Aug 1, 2010 in |
The retrospective study on prescribing patterns of antihypertensives showed that the prevalence of hypertension was predominantly more with male patients than in female patients. It was also found that the average age of the overall study population was 56 years. The average age of the population clearly indicates the elderly patients were affected more. The results indicates that around 57.6% of the patients were brought to normal or prehypertension after the successful treatment with antihypertensive agents. The remaining 42.4% were brought to high normal after the treatment. The study revealed that the physician were treated 44.73% of the patients population with Ramipril alone as mono therapy, 21.05% were treated with Atenolol, 10.52 % were treated with Amlodipine, and other patients are treated with Amiodarone, Prazonin HCL, and Telmisarten etc. The most commonly prescribed combination was found to be Ramipril with Atenolol and it is followed by Ramipril with Amlodipine. The overall percentages of these combinations were found to be 37.25 % and 25.0%...
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Posted by admin on Aug 1, 2010 in |
The non-proliferative activity of isolated saponins, gymnemagenol (C30H50O4) from Gymnema sylvestre and dasyscyphin C (C28H40O8) from Eclipta prostrata leaves were tested under on HepG2 cells under in vitro conditions. Both gymnemagenol and dasyscyphin C exhibited non-proliferative activity on HepG2 cells at 24 h with the IC50 value of 18.5 and 23.5μg/ml respectively. 5-Fluorouracil (5FU) a positive control showed the IC50 value of 1.34μg/ml. The isolated saponins were not toxic to Vero cells. From this study, it can be concluded that the saponins, gymnemagenol and dasyscyphin C have significant non-proliferative activity on HeLa cells under in vitro...
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Posted by admin on Aug 1, 2010 in |
The community pharmacist, being an important member of the healthcare team and society, can make successful efforts to counsel the sufferer and guide him about this disease. Pharmacist is now becoming more patient oriented than product oriented and have brought many changes in life of patients. Hypertension or high blood pressure is a condition in which the blood pressure in the arteries is chronically elevated. With every heart beat, the heart pumps blood through the arteries to the rest of the body. Blood pressure is the force of blood that is pushing up against the walls of the blood vessels. If the pressure is too high, the heart has to work harder to pump, and this could lead to organ damage and several illnesses such as heart attack, stroke, failure, aneurysm, or renal failure. Cardiovascular diseases caused 2.3 million deaths in India in the year 1990; this is projected to double by the year 2020. Hypertension is directly responsible for 57% of all stroke deaths and 24% of all...
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Posted by admin on Aug 1, 2010 in |
Alzheimer’s disease (AD) is a leading cause of morbidity and mortality and its prevalence is continuously increasing. AD is characterized to varying degrees by Amyloid β, neurofibrillary tangles, gliosis, synaptic and neuronal loss leading to a decline in memory & apraxia agnosia and several neuropsychiatric changes like anxiety and depression etc. Increased age, oxidative stress and neuroinflammation are considered to be the major risk factors implicated in the progression of AD. Various signaling systems, such as vasoconstrictor peptides, inflammatory mediators, growth factors, are involved in the pathogenesis of AD. At present, no promising therapy is available due to lack of understanding of signaling culprits involved in the pathogenesis of AD. Animal models are being developed to better understand the disease pathogenesis and develop drugs for this ailment. In the present review, various common lab animal models for AD are discussed, which has been used, can be used and which will open new vistas for developing new drugs to treat this cognitive...
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