Posted by admin on Aug 1, 2010 in |
Floating matrix tablets of metformin hydrochloride were developed and evaluated for increase bioavailability by increasing gastric residence time and sustained release of drug on the upper part of gastrointestinal tract thereby diminishing side effects and enhanced patient compliance. Metformin hydrochloride, an oral antidiabetic having narrow absorption window in the upper part of gastrointestinal tract, was formulated as floating matrix tablet using gas generating agent (potassium bicarbonate) and hydrophilic gelling polymer hydroxyl propyl methyl cellulose (hypromellose) by wet granulation technique. The prepared formulations were evaluated for floating time and in vitro drug release characteristics using modified dissolution method. All formulations possessed good floating properties with total floating time more than 12 hours. Optimization study included 22 factorial design with t50% and t80% as the kinetic parameters. Matrix characterization included photomicrograph, which showed definite entrapment of the drug in the matrix. Formulations with high amount of hypromellose were found to float for longer duration and provide more sustained release of drug. The formulated drug delivery system was found to be independent...
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Posted by admin on Aug 1, 2010 in |
A series of 6- methyl- 2 – oxo N- (4- oxo- 2- substituted phenyl- 1, 3- thiazolidin- 3- yl)- 4- substituted phenyl- 1, 2, 3, 4- tetrahydropyrimidine- 5- carboxamide have been synthesized and evaluated for their anti-inflammatory activity by carrageenan induced rat paw edema method. The reaction was carried out simply by heating a mixture of three components dissolved in ethanol with a catalytic amount of hydrochloric acid at reflux temperature. The product of this novel one pot, tree-component synthesis that precipitated on cooling of the reaction mixture was identified correctly by Biginelli as 3, 4- dihydropyrimidine- 2 (1H) – one. The synthetic potential of this new heterocyclic synthesis remained unexplored for quite some time. In the 1970s and 1980s interest slowly increased, and the scope of the original cyclocondensation reaction was gradually extended by variation of all three building blocks, allowing access to a large number of multi functionalized dihydropyrimidines. The resulting dihydropyrimidinones and their sulphur analogs posses antibacterial, antiviral, antitumor, anti-inflammatory, antihypertensive as well as calcium channel...
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Posted by admin on Aug 1, 2010 in |
A simple reverse phase HPLC method was developed for the simultaneous estimation of Ranitidine hydrochloride and Domperidone present in combined tablet dosage forms. Efficient chromatographic separation was achieved on Phenomenax C18 stationary phase (250 X 4.6 mm i. d., 5μ particle size) with simple mobile phase combination of phosphate buffer: acetonitrile: methanol 40: 30: 30 (V/V/V) in an isocratic mode at a flow rate of 1.5 mLmin-1 at 210 nm. The retention times were 2.417 and 7.375 (±0.5) min for Ranitidine hydrochloride and Domperidone respectively. The proposed method has been applied successfully for the simultaneous analysis of Ranitidine hydrochloride and Domperidone in combined tablet dosage form with good accuracy and precision. The method herein described can be employed for quality control and routine analysis of Ranitidine hydrochloride and Domperidone in pharmaceutical dosage...
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Posted by admin on Aug 1, 2010 in |
The objective of the present investigation of hepatoprotective activity of various Fruit extract of Semecarpus anacardium in paracetamol induced liver damage model in Wistar rats. Liver damage was produced by paracetamol (2gm/kg, p. o.) in 1% CMC. The Plant extracts (200mg/kg, p. o.) were administered every 24 hrs for seven days, while standard group received N-acetyl l- cysteine. At the end of the study the marker enzymes in serum were analyzed. The aqueous as well as alcoholic extract showed significant hepatoprotective activity and efficacy of alcoholic extract was almost comparable to that of N-acetyl l-...
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Posted by admin on Aug 1, 2010 in |
Novel 2- Aminothiazole derivatives were synthesized by the reaction of 2-aminothiazole (1) with chloroacetylchloride in presence of K2CO3 in chloroform afforded 2- chloro- N- (thiazol – 2- yl) acetamide (2). Compound (2) on condensation with substituted phenols in presence of K2CO3 in acetone afforded the title compound (3a-g). The chemical structures of the synthesized compounds were elucidated on the basis of IR, 1H NMR data. The synthesized compounds were screened for antibacterial and antifungal activity among them the compound 3c and 3d have shown significant inhibition of bacterial and fungal growth....
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