Posted by admin on Apr 30, 2020 in |
Alcoholic liver disease (ALD) comprises a wide variety of damage, starting from steatosis to liver cancer. ALD results from a multifactorial interaction between behavioral, ecological and hereditary factors. This study aimed to evaluate the hepatoprotective effect of ethanolic extract of Premna tomentosa (EEPT) on ethanolic toxicity liver. The characterization of EEPT extract was performed using standard biochemical analysis. Thirty-six male albino Wistar rats were divided into 6 groups; Hepatotoxicity was induced using 40% ethanol (1ml/100gm b.w) for 10 days. Group I received distilled water. Group II, III, IV, V were administered with 40% ethanol (1 ml/100gm); Group III and IV was given EEPT (500 and 750 mg/kg, b.w), Group V receives Ayurvedic drug (Liv 52 1ml/100gm) and Group VI was given EEPT (500 mg/kg) for forty-five days. Total body weight, wet weight of the liver, serum total bilirubin, aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase was compared and assessed statistically. EEPT of 500 and 750 mg/kg shows a significant (p<0.01) reduction of liver enzymes, it shows the protection against ethanol-induced...
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Posted by admin on Apr 30, 2020 in |
Aim and Objectives: The present study was an attempt to investigate the effect of Thetran vidhai kudineer (TVK) on streptozotocin (STZ) induced diabetes in male Wistar rats. Methods: TVK, is a Siddha polyherbal formulation containing four ingredients includes Strynchnos potatorum, Terminalia chebula, Cassia auriculata, and Limonia acidissima. 6-8 week old 30 male Wistar albino rats fed with normal diet ad libitum and free access to water containing 10% fructose (w/v) for 5 weeks. After five weeks of dietary manipulation, all groups except the normal control group received a single injection intraperitoneal (ip) of STZ (40 mg/kg b.w.) dissolved in citrate buffer (pH 4.4). One week after the STZ injection, animals with non-fasting blood glucose levels > 250 mg/dl were considered as diabetic. Four groups of STZ-induced diabetic rats were orally treated with metformin (100 mg/kg) and TVK (300, 600, and 1200 mg/kg b.w), respectively. Bodyweight recording was done weekly; fasting blood glucose levels were measured at the end of 8th week, 10th week, 12th week. Lipid profile, SGOT, SGPT,...
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Posted by admin on Mar 31, 2020 in |
In targeted drug delivery systems, there is one of the most important drug delivery systems is colon targeting drug delivery system. This system is mainly used in the treatment of diseases like colonic cancer, ulcerative colitis, Crohn’s disease. For local treatment of various bowel diseases colon is highly desirable. For the systemic action of nonpeptide drugs i.e., cardiovascular and antiasthmatic agents and protein-peptide drugs such as insulin, calcitonin, colon targeting is apparently useful. There are various approaches that have been proposed for targeted colon delivery; they include the pH, pressure controlled, time-controlled, microflora, osmotic controlled, and multi-particulates and novel techniques. The carriers used in this system are microsphere, synthetic polymers, liposomes and nanoparticles, matrix tablets and compression coated tablets...
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Posted by admin on Mar 31, 2020 in |
The aim of this work is a comparison of anti-inflammatory properties of the molecular pectin complex with 10% acetylsalicylic acid (P-ASA) and acetylsalicylic acid (ASA) in equimolar doses on the model of carrageenan-induced paw edema of rats. The study was carried out on a total of 28 adult male Sprague Dawley rats at 7 months of age. 30 min after injection of 1% aqueous solution of carrageenan to the plantar aponeurosis, studied drugs were orally administered once at the doses of 10, 20, 40 mg/kg ASA and 100, 200, 400 mg/kg P-ASA. The severity of edema, pain sensitivity, leukocyte count, its subpopulation ratio and IL-1β, IL-6, IL-8, TNFα level were determined. Normality, t-test and Mann-Whitney tests were used for statistical analyses. The ulcerogenic effect of P-ASA (dose 400 mg/kg) is significantly less than that of ACA (dose 40 mg/kg). The analgesic effect of P-ASA is comparable to ASA at equimolar doses. The anti-edema effect of ASA at the doses of 10 and 20 mg/kg is more pronounced than that...
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Posted by admin on Mar 31, 2020 in |
Histomorphological changes were observed to assess the effect of fungus on gill and pancreas of Channa striatus. The most frequent histological changes detected in the gills included hypertrophy, hyperplasia and fusion of secondary lamellae. Other lesions found were vacuolization and blood congestion in Pancreas. The colonization of aquatic fungi in teleost fish is a severe problem affecting both wild and cultured fish population. However, the fungal infection is more abundant in the captive environment which adversely affects fish industry. An external fungal infection cause lesions, subsequently become enlarge and may lead death. Stress, physical injury, malnutrition and poor water quality increase the susceptibility of fungal infections. Gill and Pancreas are responsible for vital functions such as respiration, excretion, erythropoiesis, regulating blood pressure and the accumulation. The alterations found in these organs are easier to identify than functional ones and serve as warning signs of damage to animal health. Hence, the study of tissue deformities in respect to fungal infection which is commonly encountered in freshwater aquaculture needs to be...
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