Posted by admin on Feb 29, 2020 in |
The oral route of drug administration is one of the simplest route of drug administration throughout the world because its patients convenience. The drug administered through orally should possess good aqueous solubility for better oral absorption and thus bioavailability will increase. But it was found that 30-40% of the drug shows low solubility thus bioavailability profile will be affected. Self-emulsifying drug delivery (SEDDS) system is a novel therapeutic drug delivery system of those new drugs whose aqueous solubility is very poor. Thus, by this delivery system the new drugs can be administered to the body via oral route and hence therapeutic effect will be desired appropriately. The most unique feature of this delivery system can form oil in water emulsion when diluted in an aqueous phase. Thus, this delivery system enhances the rate and extent of drug or absorption when given by oral route. The cost of this delivery system is affordable as it can consist natural oil and common excipients. Thus, large scale production is also possible for...
Read More
Posted by admin on Feb 29, 2020 in |
The aim of the present work was to formulate and evaluate Fast Dissolving Tablet (FDT) of a combined oral dosage form of Paracetamol (PCM) and Chlorpheniramine Maleate (CPM). Paracetamol is an antipyretic and Chlorpheniramine maleate is an antihistamine used to relieve symptoms of hay fever, allergy, and the common cold. Combining both the drugs can be used as pain-relieving and fever in cold and flu conditions. Three super disintegrating agents such as Cross Carmellose Sodium (CCS), Sodium Starch Glycollate (SSG) and Microcrystalline Cellulose (MCC) at different concentrations were used to enhance the disintegration and to improve the bioavailability of the drugs. By using the direct compression method, the FDT’s were prepared and evaluated for hardness, weight variation, wetting time, friability, disintegration time, in-vitro dissolution study, Thermogravimetric Analysis (TGA), and stability studies. A new Spectrophotometric method was developed for simultaneous estimation of PCM and CPM in FDT. Among all six formulations, F2 with CCS 27% concentration found the best formulation. F2 resulted in best wetting time i.e. 26 sec, good...
Read More
Posted by admin on Feb 29, 2020 in |
Carboplatin is the first-line choice of drug for ovarian cancer. In this investigation, we have prepared carboplatin silver nanoparticles (CSNP’s) by electrostatic adsorption. The size range was found to be 53-87 nm and the zeta potential was in the range of -36 to -61. After coating with hyaluronic acid and drug the size was observed to be around 80 nm and zeta potential was -41. After coating the monodisperse particles with a narrow polydispersity index value of 0.49-0.51 were obtained. The pH of silver nanoparticles without coating was in between 5.1-5.9. Atomic force microscopy confirms the spherical shape of nanoparticles. The entrapment was found to be 70-87%. Formulation F3 was found to have more entrapment efficiency and the release extended up to 6 h in phosphate buffer saline pH 7.4. The uniform concentration of trisodium citrate and tannic acid as a reducing agent along with high concentration of hyaluronic acid in F3 formulation able to entrap high drug load and release for an extended period. The drug release follows...
Read More
Posted by admin on Feb 29, 2020 in |
Delayed wound healing is producing a high economic burden on the society and is generally associated with Diabetes mellitus or a related complication thus needs safe treatment like herbal formulation. Dermas heal cream (an anti-diabetic ayurvedic formulation) was evaluated for wound and burn healing potential in normal and diabetic rats. The effect of Derma heal cream on wound healing has been studied in diabetic and normal animals and compared with standard using the excision wound model. Diabetes was induced by a single dose of Streptozotocin 55 mg/kg i.p. Rats with blood glucose levels >250 mg/dl are considered as diabetic and included in the study for incision, excision and burn heal model. Rats treated with derma heal cream (DHC) at doses 1000 mg/kg dose per day were applied topically in the excision wound model, treated DHC shows significant effect reduction in period of 21st day and wound area is (5 ± 1.15 mm)and normal group wound area is (1.66 ± 2.12 mm) as compared to diabetic control group (25 ±...
Read More
Posted by admin on Feb 29, 2020 in |
Drug delivery to targeted sites is restricted by various barriers. The conventional drug delivery systems like tablets, capsules, suspensions, emulsions, elixirs, lotions etc. are being encountered with a number of issues such as poor bioavailability, drug shelf life, drug-excipients incompatibilities and patient in compliance. Thus with the advent of novel drug delivery systems such as liposomes; nanoparticles are proving to be a better option nowadays. As evolution in the drug delivery system, a new system with lesser side effects was introduced in 2011 known as Spanlastics. They are elastic, deformable surfactant-based nanovesicles in which an aqueous solute solution is entirely enclosed. They are shown to be chemically more stable. They provide targeting and controlled release of natural pharmaceutical compounds and have improved several drawbacks of the conventional dosage form. The current review emphasizes the utility of spanlastics, mechanism of penetration, different preparation approaches, their evaluation parameters and...
Read More
