Posted by admin on Jan 31, 2020 in |
Objective: In the present dissertation work, the aim was to prepare self-emulsifying drug delivery systems (SEDDS) of mirtazapine to improve its solubility with a view to enhance its oral bioavailability. Methods: The prepared SEDDS was the concentrate of the drug, oil-Capmule MCM EP, surfactant tween 80 and PEG 400 as a co-surfactant. The optimized microemulsion was converted into solid form by adsorption technique by using as Neusiline US2 solid carrier. The formulation was evaluated for various tests such as solubility, drug content, emulsification time, phase separation study, dispersibility test, droplet size analysis and PDI determination and zeta potential and in-vitro release study, and in-vitro permeation study. Results: The optimized formulation F5 showed drug release (96.97 ± 1.89), droplet size (153), Zeta potential (-30mv). All formulations of mirtazapine SEDDS were showed faster dissolution than plain drug, mean bioavailability of mirtazapine increase in respect to the plain drug. The F5 can be further used for the preparation of various solid SEDDS. In conclusion, self-emulsifying drug delivery system has become promising tool...
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Posted by admin on Jan 31, 2020 in |
Pectin is a complex polysaccharide and has been used in food and pharmaceutical industries. The current study aimed to determine antioxidant and cytotoxic activities of pectin from peels of grape fruit (GP) and lemon (LP) by ferric reducing power (FRP) assay and brine shrimp lethality bioassay respectively. In addition, antioxidant and cytotoxic activities of GP and LP were compared with food-grade pectin (FGP). GP and LP exhibited positive results of antioxidant and cytotoxic activities. The percentage FRP of GP at 10 to 100 µg/ml was found to be higher as compared to FGP while LP showed closed values to that of FGP. The observed percentage mortality of shrimps at 10 to 1000 µg/ml by LP was found to be higher as compared to percentage mortality caused by FGP. Percentage mortality of shrimps by GP and FGP showed closed values. The LC50 of LP was found to be lower than that of FGP but close to the LC50 of standard drug etoposide. The LC50 of GP was closed to that...
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Posted by admin on Jan 31, 2020 in |
Coenzyme Q10 (ubiquinone) is a lipophilic benzoquinone substance. It is a pivotal component to the oxidative phosphorylation in the inner mitochondrial membrane of all aerobic cells as well as diminishes reactive oxygen species (ROS). Exogenous sources for CoQ10 are grapes seed oil, walnuts, pistachios, spinach, and sesame seed. At present, it is being utilized as an antioxidant agent. Recent studies have revealed its neuroprotective action. In the present review, the comprehensive pharmacological benefits of coenzyme Q10 on the central nervous system (CNS) has been revealed. Many studies were taken into considerations and compiled in accordance with their activities. Amongst those, the study using in-vitro models referring to neuronal toxicity and animal models of neurodegenerative diseases have been covered. Multiple outcomes have now evolved assisting the role of reactive oxygen species and neuroinflammation in the pathogenesis of the neurodegenerative disorder. The drug coenzyme Q10 has been administered in a human subject with reference to their age and body weight. In case of increased oxidative stress and few selective cases of...
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Posted by admin on Jan 31, 2020 in |
A novel copper (II) complex has been synthesized with Schiff base ligand obtained by the reaction of substituted carbohydrazone and thiosemicarbazide hydrochloride from the condensation reaction of ester and primary aromatic amine. The synthesized ligand and its copper (II) complex were characterized by various spectroscopic techniques like FT-IR, H1 NMR, UV-Visible, Fluorescence, powder XRD and Thermo-gravimetric analysis. Ligand and its copper complex were also screened for antioxidant and anticancer activities. In Cu (II) complex 1:2 copper to ligand molar ratio was obtained from analytical data. The molar conductance data confirm that complex is non- electrolytic in nature. Based on the electronic and magnetic data, a distorted octahedral geometry is ascribed for the Cu (II) complex. Ligand and its Cu (II) complex showed considerable anticancer activity against MCF-7 cell lines and more pronounced antioxidant activity in the presence of DPPH. Furthermore, molecular docking of ligand and its copper complex into the binding site of topoisomerase IIα was carried out using Auto Dock Vina software which demonstrated significant binding energies of...
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Posted by admin on Jan 31, 2020 in |
Background: Acute respiratory distress syndrome (ARDS) is a medical condition occurring in critically ill patients characterized by extensive inflammation in the lungs and associated with several complications. Therefore, the present study aimed to identify the common risk factors associated with ARDS in Hail Region, Northern Saudi Arabia. Methodology: This study investigated retrospectively 68 patients with ARDS clinical presentations during the period from January 2015 to January 2016 in King Khalid Hospital, Hail, Saudi Arabia. Results: Out of 68 patients with ARDS clinical presentations, ARDS was verified in 38/68 (55.9%). Out of 38 ARDS patients, 21/38(55.3%) were males and 17/38 (44.7%) of the 68 studied patients, pneumonia, trauma, H1N1 infection and fibrosis were identified in 50(73.5%), 3(4.4%), 13(19.1%) and 12 (17.6%), respectively. Out of the 38 ARDS patients, 29/38 (76.3%) died. Conclusion: ARDS is common in Hail Region and a common cause of patients to be admitted to specialized intensive care units. Inhalation injuries associated with pneumonia, H1N1 infection and fibrosis were an independent risk factor for ARDS. The mortality...
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