Posted by admin on Oct 31, 2020 in |
The mitogenic activity in earthworms should be accompanied by antioxidative and antimicrobial activities during the healing or regeneration of their amputated part. These activities are achieved by bioactive macromolecules in their tissue and coelomic fluid. The antioxidative activity applied to prevent the cellular function from oxidative damage and assist cell multiplication. The antimicrobial activity prevents the wounded area from bacterial infection and enhances cell division. This review aims to promote cheap natural products of earthworms to be used widely in human medicine. Thus, we reviewed how to extract coelomic fluid, preparation of tissue homogenate (G-90) and application of mitogenic, antioxidative, antimicrobial activities on experimental animal rats, mice and rabbits. These products were efficient for hasty wound healing, the proliferation of damaged bone, boosting of immune cells and nerve cell regeneration without carcinogenic and mutagenic characteristics. Therefore, the biotechnological application of tissue homogenates and coelomic fluid should get due...
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Posted by admin on Oct 31, 2020 in |
Helicobacter pylori causative agent of acid peptic disease is a microaerophilic, spiral-shaped, gram-negative bacteria found in the gastric epithelium that may also lead to complications such as chronic gastritis, mucosa-associated lymphoid tissue (MALT) lymphoma, gastroduodenal ulcer and adenocarcinoma in stomach. Plantbioactives have always been potential therapeutics. Usage of modern bioinformatic tools plays a vital role in exploiting the potentials of alternative therapeutic molecules in managing diseases like peptic ulcers and their complications. The in-silico evaluation was carried out using molecular docking of the quorum sensing proteins of H. pylori with the ligand β-sitosterol obtained from the silver nanoparticles of Acorus calamus L. Among several given quorum sensing proteins the molecular interaction with the ligand β-sitosterol showed a high binding affinity with DnaA, PhnB, ToxB and Sip proteins. The results obtained from molecular interaction study revealed that the ligand β-sitosterol will be readily taken up by the organism, thereby facilitating easy inhibition or inactivation of quorum sensing molecules ToxB, DnaA, PhnB, and Sip, making it a novel therapeutic alternative to treat H....
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Posted by admin on Oct 31, 2020 in |
To study various types of the benign cyst, differential diagnosis, diagnosis for identification of cyst, suitable treatment options based on various types of cysts that are occurring in the ovaries. An ovarian cyst is a commonly occurring mass in reproductive-age women. Functional ovarian cysts are physiologic and usually dissolve spontaneously within a couple of menstrual cycles. A combination of oral contraceptives can be used to prevent the occurrence of these cysts. The scope of this review is to focus on the types, causes, and treatment options of benign ovarian cyst in the fertile women. Ovarian cysts are a commonly occurring condition in women nowadays. The differential diagnosis includes functional cysts, dermoid cysts, endometrioma, and another confirmatory diagnosis such as ultrasonography are used to know the type and size of the occurring mass in the ovaries. A suitable evaluation includes a medical history and physical examination, laboratory tests, and other imaging modalities. The treatment options include conservative follow-ups, medical treatment with the help of pills, and lastly, surgery depending upon...
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Posted by admin on Oct 31, 2020 in |
“Nanotechnology” is a science which deals with the particles less than the size of 100 nm. Materials at the atomic and molecular scales are engineered and manufactured by this technology. The use of nanotechnology for “phytotherapy” or treatment of various diseases by herbal medicines/drugs, including herbal drug delivery, where current and emerging nanotechnologies could enable entirely novel classes of therapeutics, has been reported. The researchers have succeeded in using nanotechnology to insert and simultaneously activate the genes delivered into plant cell walls. The nanomaterials can significantly enhance the pharmacokinetics and therapeutic index of plant origin drugs. Interestingly, pharmaceutical sciences are using nanoparticles to reduce toxicity and side effects of drugs. Herbs and herbal derivatives are of great research interest owing to their wide applications in therapeutics. Several folk evidence has been recorded in the formulations of the ancient world’s medicinal system, which have attracted researchers for their scientific validation. Various herbal compounds have been identified and showed their therapeutic efficiency against pathophysiological conditions. Employing these herbal compounds for synthesizing...
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Posted by admin on Oct 31, 2020 in |
Background: Chronic suppurative otitis media (CSOM) is defined as a persistent infection of the middle ear cleft with a perforated tympanic membrane and draining exudate for more than 6weeks. Information about the organism responsible for COSM and their antibiotic susceptibility is important for effective treatment. Material and Methods: A prospective cross-sectional study was conducted on 85 patients; the middle ear discharge sample was collected under strict aseptic conditions and antibiotic susceptibility done as per Clinical Laboratory Standards Institute guidelines. Result: 85 ear swabs were collected, and 89 bacterial isolates were identified, of which 72.94% sample with mono-microbial growth, 16.47% with polymicrobial growth, 9.41% show no growth, and the rest 1.17% was a contaminant. Among 89 isolates, 39.33% were Gram-positive, while 60.67% were Gram-negative bacteria. The most common isolates were Pseudomonas species 40.45% followed by methicillin sensitive staphylococcus aureus (MSSA) 38.20% and others 21.35%. Pseudomonas species showed 100% susceptible to colistin, linezolid, imipenem, amikacin (97%); ciprofloxacin (92%); gentamicin (95%); Ceftriaxone (83%); meropenem (93%); Netilmicin (98%) and Sulfamethoxazole and Trimethoprim(SXT) (90%)....
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