Posted by admin on Sep 30, 2021 in |
Moringa Cocanensis Nimmo is one of the important medicinal plants belonging to the family moringaceae. Moringa Cocanensis Nimmo has antipyretic, antihelmintic, antimicrobial, hepatoprotective, and anticancer activities. It is one of the most noted systems of medicine in the world. Ayurveda is based on the hypothesis that everything in the universe is composed of five basic elements viz. space, air, energy, liquid, and soil. The traditional system was proved to be more effective when compared to synthetic drugs due to reduction in side effects, adverse effects, and even a little increase in dose was not that dangerous when compared to the synthetic drugs. It was even found to be more economical and safer in all means. Hence, we have choosed the plant Moringa Concanensis Nimmo, evaluated its medicinal property and proved its antioxidant nature for replacing synthetic drug formulations. When ringer solution containing H2O2 perfused to heart preparation, the muscaranic actions of acetylcholine were not observed much, indicating the oxidative stress on frog heart induced by H2O2; this might be...
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Posted by admin on Sep 30, 2021 in |
In recent years, natural products such as Boswellic acids (BAs) have attracted researchers around the globe because of their significant potential against various diseases without any toxic effects. Boswellic acids, which belong to the pentacyclic triterpenes type of class, are extracted from the gum-resin portion of Boswellia serrata and many other different species such as Boswellia sacra, Boswellia papyrifera, and Boswellia carterii. The Boswellic acids obtained from these species are broadly classified into two categories as α-Boswellic acids and β-Boswellic acids. The six major recognized acids which are obtained from the gum resinous extract of Boswellia serrata and Boswellia carterii includes α-Boswellic and β-Boswellic acids, acetylated α-Boswellic acids and β-Boswellic acids and 3-O-acetyl-11-keto-β-Boswellic acid and 11-keto-β-Boswellic acid. In recent years, several biological potentials of Boswellic acids have been investigated, including inhibition of inflammation, anti-arthritic, anti-microbial, anti-diabetic, anti-asthmatic, anti-cancer, etc. In addition to leukotriene inhibiting property, the Boswellic acid and their analogues also possess the potential to be used against inflammatory bowel disease and neurodegenerative diseases. The most common are...
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Posted by admin on Sep 30, 2021 in |
Silymarin is a mixture of flavonolignan and polyphenolic bioactive natural products found in the milk thistle plant Silybum marianum. It has anti-oxidant, anti-inflammatory, anti-cancer, and antiviral activities potentially useful in treating several liver disorders, such as chronic liver diseases, cirrhosis and hepatocellular carcinoma. However, the benefits are curtailed by its extremely poor water solubility (<50 μg/mL), low bioavailability and poor intestinal absorption. To solve these problems, nano-based technological strategies appear to be a promising method to potentiate therapeutic action. The purpose of this study is to review the different nanostructured systems available in the literature as delivery strategies to improve the absorption and bioavailability of...
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Posted by admin on Sep 30, 2021 in |
Traditionally Psidum guajava has been used for the treatment of several kinds of disorders. The component quercetin a flavonoid that is present in the guava leaves, is responsible of having wound healing properties, so the aim and objective of the study was to Develop Herbal loaded Niosomes for the treatment of Wound Healing. To enhance the transport and efficacy of many materials through stratum corneum one of various methods expanded nowadays is the usage of new drug delivery system such as Niosomal formulations. Niosomes are self assemblies of non ionic surfactants with or without cholesterol, which can be used for both hydrophilic and hydrophobic substances. The extraction of Psidum guajava is performed by Soxhlet apparatus, and the extract is evaluated for phytochemical screening, antimicrobial activity, and TLC. Materials used in the formulation are span 60, cholesterol, diethyl ether, chloroform, buffer and extract. The herbal drug-loaded niosomes are prepared by using reverse phase evaporation method. Total twelve formulations are prepared and the formulations (F1, F2, F3, F4, F5, F6) were...
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Posted by admin on Sep 30, 2021 in |
Conventional dosage forms are the systems that don’t have complete control on their drug release, and also there is no control over the effective concentration at the target site. So in order to overcome this problem the osmotic drug delivery system was developed for the controlled delivery of drugs. This osmotic drug delivery system includes dosage forms for oral administration and implantable systems where they provide controlled delivery of drugs. These systems contain osmotic agents and a semipermeable membrane where they play an important role in the development of these delivery systems. This review mainly concentrates on the main Advantages, the principle of osmosis and how the drugs are delivered by using osmotic pressure, historical background, Types of osmotic drug delivery – Implantable and oral osmotic system, their pictorial representations and mechanisms, factors influencing the drug release, scientific developments and Marketed products of osmotic drug delivery...
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