Posted by admin on Mar 31, 2021 in |
The current coronavirus disease 2019 (COVID-19) outbreak caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged in the wholesale market in Wuhan, China in the last months of 2019 and spread to almost all countries of the world. Although several vaccines have already been developed in different countries of the world, there is currently no specific treatment for COVID-19. Some agents are used all over the world based on in-vitro, in-vivo studies, and randomized controlled studies. The number of studies on antiviral therapy has been increasing day by day. However, the efficacy of antiviral drugs for COVID-19 remains controversial. In this review, brief information about antiviral drugs favipiravir and remdesivir used for the treatment of COVID-19, the results of the conducted studies, and the possible adverse effects of these drugs are summarized. We hope that this review will provide an impression of favipiravir and remdesivir used to treat and control COVID-19 patients until the approval of specific drugs that target...
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Posted by admin on Mar 31, 2021 in |
Marine bacteria have the potentiality to produce diverse bioactive molecules such as pigment. Therefore, it needs to exploit and identifying a novel type of pigment from marine bacteria for Industrial applications. This study aimed to investigate the marine bacterial pigment against antioxidant and anti-cancer properties; the marine bacteria producing pigment were isolated from water samples collected at the coastal of Marakkanam (TN), India. The isolates were screened out based on the growth characteristics and performance of different media and the strain designated as MB4, which was taken as further studies. The strain MB4 characterized by SEM analysis showed that coccoid cell morphology, nonsporulating, Gram-positive with yellow pigmentation and positive for MR-VP, catalase, lipase, acetoin production, and hemolysis. The cells were able to tolerate 10 percent NaCl concentration and ability to grown pH 9. The MB4 strain was shown a higher wave-number (1395.77) cm-1 against Raman Intensity to identify pigment production. The methanolic extracted pigment was produced at a maximum peak at 260 nm. The yellow-pigmented crude extract checked for...
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Posted by admin on Mar 31, 2021 in |
Medicinal plants are becoming globally recognized because of their acclaimed therapeutic potentials. This study evaluated the plasma glucose and serum lipid profile levels among university students consuming Glycine max (Soya bean) in Nnewi, Nigeria. A total of thirty (30) apparently healthy male subjects aged between 18 and 30 years were randomly recruited from medical students to serve as both test and control groups. Each subject was advised to abstain from soya bean and similar food consumption for a period of three weeks prior to the commencement of the study. Subsequently, in addition to their normal diet, each of the subjects was given 25 g of soya bean powder before breakfast daily for 30 consecutive days. 6 mls each of baseline and test samples (after an overnight fast) were collected at day 0 and 31 respectively from each subject for the determination of plasma glucose and lipid profile parameters (TC, TG, LDL-C, HDL-C, and VLDL-C) using standard laboratory methods. Results showed no significant alterations in the mean body mass index...
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Posted by admin on Mar 31, 2021 in |
Chlorpyrifos is one of the commonly detected pesticides found in food and water. Extensive use of it in agriculture and its persistence in the environment have raised public concern to overcome the pollution and toxicity problems. Exposure to chlorpyrifos poses several harmful effects to animal and human health. And the pathology in neurodegenerative diseases is mainly because of mitochondrial dysfunction. GSH depletion proceeding with mitochondrial dysfunction is therefore considered as the earliest triggering factor of neurodegeneration. In the present study using Drosophila melanogaster a fly model for human neurodegenerative disease, we investigated the effects of chlorpyrifos on glutathione, reactive oxygen species, mitochondrial Complex I, and Complex II activities. We found that chlorpyrifos generates reactive oxygen species, diminished the levels of reduced glutathione (GSH) concurrently increasing oxidized form of glutathione (GSSG), this preceded with inhibition of mitochondrial enzymes such as complex I and complex II activities, ultimately leads to motor dysfunction and death of Drosophila...
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Posted by admin on Mar 31, 2021 in |
Luffa acutangula (L.) Roxb. (Family: Cucurbitaceae) has been used in the folkloric Indian medicinal system to treat numerous health conditions. The fruits of the plant have been used in dysentery, jaundice, diabetes, hemorrhoids, leprosy, and ringworm infection. The present study aimed to establish the hypoglycemic effect of the aqueous fruit extracts of Luffa acutangula was investigated in normal, glucose load conditions and streptozotocin (STZ)-induced diabetic rats. In normal rats, the aqueous extract of the fruit of L. acutangula (50 and 100 mg/kg/p.o.) significantly (P < 0.001) reduced the blood glucose levels from 65.2–49.4 and 68–48 mg% 2 h after oral administration of fruit extract and also significantly lowered the blood glucose in STZ diabetic rats from 67–101 and 64–89.2 mg% 21 days after daily oral administration of the extract (P < 0.001). The results suggested that the aqueous fruit extract of L. acutangula has a potential hypoglycemic effect in diabetic rats and authenticates the folkloric use of the plant for the management and treatment of...
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