Posted by admin on Aug 31, 2022 in |
Background: Artificial sweeteners are well-known today because of their high sweetness property with low or no caloric intake. However, consuming artificial sweeteners interferes with normal physiological processes within our bodies. Objectives: The study investigates biochemical changes in blood glucose homeostasis and hematocrit parameters during and after terminating intakes of aspartame and sucralose in male albino rats. Methods: the experimental design included 54 male albino rats in five groups, twelve rats for each group, except the control group contained six rats. 2 and 4 g/kg of sucralose and 0.8 and 1.6g/kg of aspartame were given orally every day for 12 weeks. Aspartame and sucralose were omitted for a further six weeks. Fasting blood glucose, insulin, insulin resistance (HOMA-IR), (HbA1c), and CBC were measured. Results: HOMA-IR increased in rats supplemented by high doses of either sweetener and HbA1c significantly increased in rats fed on low and high concentrations of Sweetal® (6.43 and 6.85 mmol/mol, respectively). Conclusion: Although terminating artificial sweeteners intake decreases blood glucose gradually, artificial sweeteners intake is still a...
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Posted by admin on Aug 31, 2022 in |
Background: Migraine is one of the major causes of disability affecting the productivity, physical, psychological and social well-being of patients. To conduct a systematic review and network meta-analysis (NMA) of randomized trials investigating the effect of anti-calcitonin gene-related peptide monoclonal antibodies (anti-CGRP mAbs) on productivity and physical functioning of adults migraineurs. Methods: Databases were searched from inception to May 2021. Work productivity and physical functioning were evaluated using change in patient-reported Work Productivity and Activity Impairment (WPAI) and Migraine Physical Function Impact Diary (MPFID) scores. The NMA was conducted with fixed-effects model in Bayesian framework. Results: Overall, 26 studies (4,393 migraineurs in five randomized trials) were included with a treatment course of at least 12 weeks. With limited treatments in network formed, subcutaneous injections of fremanezumab 675+225+225 mg QM and 225+225+225 QM were more effective in reducing loss of overall work productivity, activity impairment, and impairment experienced while at work in chronic and episodic migraine, respectively, with the higher median difference in WPAI scores from baseline compared to a...
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Posted by admin on Aug 31, 2022 in |
Centella asiatica (Linn) Urban, a herb of immense medicinal properties, has been widely used by traditional healers in the treatment of skin diseases, mental fatigue, anxiety, rheumatism, eoilepsy and leprosy. In the present investigation, the antibacterial activity of ethanol, acetone and aqueous extracts of Centella asiatica were tested in-vitro against seven bacterial species viz. Staphylococcus aureus, Salmonella typhi, Salmonella paratyphi, Klebsiella sp., E. coli, Bacillus sp. and Pseudomonas sp. by well diffusion method. The ethanol extract inhibited the growth of Bacillus sp. and S. aureus, maximally (14 mm each), followed by that of E. coli (12 mm) and Klebsiella sp. (11 mm). The extract unaffected the growth of Salmonella typhi, Pseudomonas, and Salmonella paratyphi. The acetone extract inhibited the growth of Bacillus sp. (10 mm); the other six bacteria remained unaffected. Likewise, the aqueous extract also inhibited the growth of none of the test bacteria in this...
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Posted by admin on Aug 31, 2022 in |
A simple, one-pot, and efficient method for the synthesis of benzimidazole derivatives via the condensation of o-phenylenediamine and substituted aromatic aldehydes in the presence of Moringa oleifera (MO) seed extract acts as a biocatalyst under microwave irradiation. The method provides several advantages such as simple operation, clean reaction ways, and high to the excellent yield of product. The aqueous extract of Moringa oleifera (MO) seed as a green catalyst corresponds to an excellent yield for the synthesis of 2, 4, 5-trisubstituted imidazole derivatives under microwave irradiation method as a greener heating technique and one-pot multicomponent reaction acts as a green routine. All synthesized compounds were characterized by spectroscopic techniques such as FT-IR, 1H-NMR, 13C-NMR and LC-MS...
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Posted by admin on Aug 31, 2022 in |
The binding capacity of mucoadhesive polymers with gastric mucin prolongs the gastric residence time, increasing bioavailability. In the present research work, an attempt was made to formulate and evaluate sustain release mucoadhesive matrix tablet of Acyclovir. In the present work, an effort has been made to evaluate the effect of mucoadhesive polymers on the release characteristics of mucoadhesive matrix tablets of Acyclovir. Matrix tablets were prepared by wet granulation method using different types and levels of polymers viz. Chitosan and HPMC K4M. Tablets were evaluated for thickness, friability, hardness, uniformity of weight, the content of active ingredients, mucoadhesive strength, and in-vitro dissolution studies. The studies indicated that the drug release can be modulated by varying the concentrations of polymers. It was observed from the optimization studies that the F3 formulation has exhibited the best release profile of the drug and can sustain the drug release for 8 h with optimum mucoadhesive...
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